TOLERO 20mg Tablets/Film-coated Price, Uses, Alternatives, Dose, and more in UAE 2023
TOLERO 20mg Tablets/Film-coated
Drug name TOLERO 20mg
Active substance Tadalafil
Size : 4Õs Blister
Company : TABUK PHARMACEUTICAL MANUFACTURING CO.
Import: SAUDI ARABIA
Uploaded By : Admin
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Tolero 20mg tablets (price/uses/side effects) in United Arab Emirates 2023
Tolero 20mg tablets
Tolero 20mg is a medication used to treat myelodysplastic syndromes (MDS), a group of blood disorders that affect the bone marrow and blood cells. Tolero 20mg belongs to a class of drugs called hypomethylating agents and specifically is an inhibitor of the DNA methyltransferase enzyme.
Mechanism of action of Tolero 20mg work
Tolero 20mg works by inhibiting the activity of an enzyme called DNA methyltransferase, which is involved in regulating the activity of certain genes. In MDS, the activity of this enzyme is often increased, leading to the abnormal growth and division of blood cells. By inhibiting the activity of DNA methyltransferase, Tolero 20mg helps to normalize the growth and division of blood cells, thereby reducing the symptoms of MDS.
Uses of Tolero 20mg
Tolero 20mg is intended for use in adults with a specific subtype of MDS called International Prognostic Scoring System (IPSS) Intermediate-2 or High-risk MDS. It is also used in patients with Chronic Myelomonocytic Leukemia (CMML) who require treatment.
Tolero 20mg is not recommended for use in patients who are pregnant or breastfeeding, or those who have had a previous allergic reaction to the medication.
Side effects of Tolero 20mg
Like all medications, Tolero 20mg can cause side effects. The most common side effects associated with the drug include fatigue, nausea, and diarrhea. These side effects are usually mild and go away within a few days.
Other potential side effects include a low white blood cell count, anemia, and increased risk of infection. In rare cases, some people may experience more serious side effects such as liver or lung toxicity.
TOLERO 20mg Tablets are a medication used to treat a variety of conditions, including depression, anxiety, and obsessive-compulsive disorder. This article will explore the uses, side effects, and precautions associated with TOLERO 20mg Tablets.
Welcome to Dwaey, specifically on TOLERO 20mg Tablets/Film-coated page.
This medicine contains an important and useful components, as it consists of Tadalafil.
TOLERO 20mg is available in the market in concentration 20mg/Tablet and in the form of Tablets/Film-coated.
TABUK PHARMACEUTICAL MANUFACTURING CO. is the producer of TOLERO 20mg and it is imported from SAUDI ARABIA.
The most popular alternatives of TOLERO 20mg are listed downward .
Lets know how to use TOLERO 20mg Tablets/Film-coated
Concurrent use of organic nitrates, nitrates and nitric oxide donors. Men with cardiac disease for whom sexual activity is inadvisable. Recent MI (within 90 days) or stroke (within last 6 mth), hypotension (<90/50 mm Hg), unstable angina, heart failure, uncontrolled arrhythmias or hypertension.
Use caution in patients with anatomic deformation of penis, cardiovascular disease, left ventricular outflow obstruction, myocardial infarction in preceding 90 days, unstable angina, angina occurring during sexual intercourse, NYHA class 2 or greater heart failure in preceding 6 months, uncontrolled arrhythmias, hypotension, uncontrolled hypertension, cerebrovascular accident in preceding 6 months, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, conditions predisposing to priapism, concomitant use of CYP3A4 inhibitors Hepatic or renal impairment; CV diseases; anatomical penile deformation; predisposition to priapism; child <18 yr. Discontinue and seek medical advice if there is sudden vision loss or decreased vision in one or both eyes or tinnitus, dizziness or sudden loss or decrease in hearing, while taking Tadalafil. Seek immediate medical advice if erection last > 4 hr.
Tadalafil is a phosphodiesterase type-5 inhibitor.
Concurrent use increased risk of hypotension with beta-blockers; increased risk of priapism with other drugs for erectile dysfunction, e.g. alprostadil; increased heart rate with theophylline; decreased tadalafil serum concentration with CYP 3A4 inducers e.g. rifampicin, efavirenz, carbamazepine, nevirapine, barbiturates, phenobarbital, phenytoin, ribabutin; increased tadalafil serum concentration with CYP3A4 inhibitors e.g. azole antifungals, protease inhibitors, cimetidine, macrolides. Potentially Fatal: Enhanced hypotensive effect with nitrates and nicorandil.