ACEFLAM 100 mg Tablets/Film-coated

What is ACEFLAM 100 mg

ACEFLAM 100 mg is a film-coated tablet containing Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID). It is widely used to relieve pain and inflammation in musculoskeletal and joint conditions.

This medicine is typically prescribed for:

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Other conditions involving chronic inflammation and pain

Aceclofenac provides both analgesic (pain-relieving) and anti-inflammatory effects. It works similarly to other NSAIDs like diclofenac but tends to have improved gastrointestinal tolerability in many patients.

By reducing the production of chemical mediators involved in pain and inflammation, ACEFLAM helps improve joint mobility, reduce swelling, and improve the quality of life in patients suffering from chronic pain disorders.

How to use ACEFLAM 100 mg

To ensure effective and safe usage of ACEFLAM 100 mg, follow these guidelines:

• Standard dosage: One tablet (100 mg) taken twice daily, preferably morning and evening.
• With meals: Take the tablet with or after food to minimize the risk of gastrointestinal discomfort.
• Swallow whole: Do not chew, break, or crush the tablet. Swallow it with a full glass of water.
• Consistency is key: Take it at the same times every day for optimal effectiveness.
• Missed dose: If you forget to take a dose, take it when you remember. If it's close to your next dose, skip the missed one. Never double up.

Important: Always follow your doctor's prescription. Do not adjust your dosage without medical advice.

Mode of Action ACEFLAM 100 mg

Aceclofenac works by inhibiting the enzyme cyclooxygenase (COX), specifically COX-2, which plays a significant role in the production of prostaglandins – the chemical messengers responsible for pain, inflammation, and swelling.

The pharmacological actions include:

• Anti-inflammatory effect: Decreases local inflammation in joints and muscles.
• Analgesic effect: Reduces the perception of pain.
• Antipyretic effect: Slightly reduces fever, though this is not its primary use.

Compared to other NSAIDs, Aceclofenac shows preferential COX-2 inhibition, which may offer an improved gastrointestinal safety profile, making it a suitable choice for long-term use in chronic conditions.

ACEFLAM 100 mg Interactions ACEFLAM 100 mg

Aceclofenac can interact with several medications, potentially altering their effects or increasing the risk of side effects. Always inform your doctor about any other drugs you are using.

Common drug interactions include:

• Warfarin or other anticoagulants: Increased risk of bleeding.
• Diuretics (e.g., furosemide): Reduced effectiveness and increased kidney toxicity risk.
• ACE inhibitors or ARBs: Possible reduced antihypertensive effect and kidney damage.
• Other NSAIDs or corticosteroids: Higher risk of gastrointestinal ulcers or bleeding.
• Digoxin: Increased serum levels and potential toxicity.
• Methotrexate: Increased risk of methotrexate toxicity due to reduced clearance.
• Cyclosporine: Enhanced nephrotoxicity.

Use caution when combining ACEFLAM with alcohol, as both can irritate the stomach lining and increase the risk of ulcers or gastrointestinal bleeding.

Dosage of ACEFLAM 100 mg

The typical recommended dosage for adults is:

• 100 mg twice daily (one tablet in the morning and one in the evening).

In special populations:

• Elderly: Use with caution. The lowest effective dose should be used.
• Hepatic or renal impairment: Not recommended in severe cases; dose adjustment may be needed in mild to moderate impairment.

This medication is not recommended for children under 18 years of age due to limited data on safety and efficacy.

Always follow your doctor's instructions and never self-adjust the dose.

Possible side effects of ACEFLAM 100 mg

Like all medications, ACEFLAM 100 mg can cause side effects. Most are mild, but some may require medical attention.

Common side effects:

• Nausea or vomiting
• Indigestion or abdominal pain
• Diarrhea or constipation
• Headache or dizziness

Less common but serious effects:

• Gastrointestinal ulcers or bleeding (may present as black stools or vomiting blood)
• Liver function disturbances (elevated liver enzymes, jaundice)
• Kidney impairment (reduced urine output, swelling)
• Allergic reactions (rash, itching, swelling of face or lips, difficulty breathing)

Contact your doctor immediately if you notice signs of bleeding, persistent abdominal pain, yellowing of the eyes or skin, or signs of a severe allergic reaction.

ACEFLAM 100 mg Contraindications ACEFLAM 100 mg

Do not take ACEFLAM 100 mg if you have any of the following:

• Allergy to Aceclofenac or other NSAIDs
• History of asthma, hives, or allergic reactions from aspirin or other NSAIDs
• Active gastric or duodenal ulcer
• Severe heart, liver, or kidney failure
• Bleeding or clotting disorders
• Pregnancy, especially in the third trimester
• Breastfeeding

Always discuss your medical history and current conditions with your doctor before starting this medication.

Storage of ACEFLAM 100 mg

To maintain the stability and efficacy of ACEFLAM 100 mg, follow these storage instructions:

• Store below 25°C (77°F): Room temperature is ideal.
• Keep in original packaging: Protects from light and moisture.
• Do not refrigerate or freeze.
• Keep away from children and pets.
• Check expiry date: Do not use beyond the expiration printed on the packaging.
• Dispose properly: Follow local regulations or consult a pharmacist for safe disposal of expired or unused medication.

Proper storage ensures the medication remains effective throughout its shelf life.