ACEFLAM 100mg Tablets/Film-coated

What is ACEFLAM 100mg

ACEFLAM 100 mg is a non-steroidal anti-inflammatory drug (NSAID) primarily used to relieve pain and reduce inflammation in various musculoskeletal and inflammatory conditions. Its active ingredient, Aceclofenac, belongs to the class of NSAIDs known for their analgesic, anti-inflammatory, and antipyretic properties.

This medication is commonly prescribed for:

• Osteoarthritis: A degenerative joint disease characterized by pain and stiffness.
• Rheumatoid arthritis: An autoimmune disorder causing joint inflammation and deformity.
• Ankylosing spondylitis: A chronic inflammatory disease affecting the spine and sacroiliac joints.
• Musculoskeletal injuries: Such as sprains, strains, and soft tissue injuries causing inflammation and pain.

ACEFLAM does not cure these conditions but helps manage symptoms to improve mobility and quality of life. It is preferred for its effective pain relief and relatively better gastrointestinal tolerability compared to some other NSAIDs.

How to use ACEFLAM 100mg

To use ACEFLAM 100 mg safely and effectively, follow these guidelines:

• Dosage: Usually one 100 mg tablet twice daily (morning and evening), or as prescribed by your healthcare provider.
• Administration: Take tablets orally with a full glass of water.
• Food intake: Take ACEFLAM with or immediately after meals to minimize gastrointestinal discomfort.
• Consistency: Maintain regular timing to keep steady blood levels of the drug.
• Missed dose: If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double doses.

Important: Do not exceed the recommended dose or duration without consulting your doctor. Prolonged use may increase the risk of side effects.

Mode of Action ACEFLAM 100mg

Aceclofenac, the active ingredient in ACEFLAM, works by inhibiting the cyclooxygenase (COX) enzymes, especially COX-2, which are critical in the synthesis of prostaglandins—lipid compounds that mediate inflammation, pain, and fever.

• Selective COX-2 inhibition: Aceclofenac preferentially inhibits COX-2, reducing inflammatory prostaglandins responsible for swelling and pain.
• Peripheral analgesic effect: By decreasing prostaglandin production, it reduces pain signals in affected tissues.
• Anti-inflammatory properties: The reduction of inflammatory mediators helps decrease redness, swelling, and tissue damage.
• Better GI safety profile: Aceclofenac has less impact on COX-1, the enzyme protecting the stomach lining, resulting in fewer gastrointestinal side effects compared to some older NSAIDs.

The onset of analgesic and anti-inflammatory effects usually occurs within a few hours, improving symptoms with continuous use.

ACEFLAM 100mg Interactions ACEFLAM 100mg

Several drugs can interact with ACEFLAM, altering its effects or increasing the risk of adverse reactions. It is crucial to inform your healthcare provider of all medications you take, including over-the-counter drugs and supplements.

• Anticoagulants (e.g., warfarin): Increased risk of bleeding due to additive effects.
• Other NSAIDs or corticosteroids: Elevated risk of gastrointestinal ulcers and bleeding.
• Antihypertensives (ACE inhibitors, ARBs, beta-blockers): ACEFLAM may reduce their effectiveness by decreasing renal prostaglandins.
• Diuretics: Risk of kidney impairment and reduced diuretic efficacy.
• Methotrexate: Increased methotrexate toxicity due to reduced renal clearance.
• Cyclosporine: Increased nephrotoxicity risk when combined.
• Digoxin: Possible increased serum digoxin levels.

Avoid consuming alcohol while taking ACEFLAM as it may increase the chance of gastrointestinal bleeding.

Dosage of ACEFLAM 100mg

Typical dosage recommendations for ACEFLAM 100 mg tablets include:

• Adults: One 100 mg tablet twice daily (every 12 hours), preferably after meals.
• Elderly patients: Use the lowest effective dose due to higher susceptibility to adverse effects.
• Patients with renal or hepatic impairment: Use cautiously with medical supervision; dosage adjustment may be necessary.
• Duration: Use for the shortest duration possible to control symptoms, unless otherwise directed.

Do not exceed 200 mg per day without medical advice. Long-term use should be regularly evaluated by your physician to monitor safety.

Possible side effects of ACEFLAM 100mg

While ACEFLAM is generally well tolerated, some individuals may experience side effects. Common side effects include:

• Gastrointestinal discomfort such as nausea, dyspepsia, abdominal pain, and diarrhea.
• Dizziness or headache.
• Skin rash, itching, or mild allergic reactions.

More serious but less frequent adverse effects may include:

• Gastrointestinal bleeding or ulceration, which can manifest as black stools or vomiting blood.
• Liver enzyme elevations or hepatitis, possibly leading to jaundice.
• Renal impairment signs such as swelling, reduced urination, or unexplained fatigue.
• Severe allergic reactions, including swelling of the face, lips, tongue, or throat (angioedema), and difficulty breathing (anaphylaxis).

Important: Seek immediate medical attention if you experience symptoms of severe allergic reactions, gastrointestinal bleeding, or signs of liver or kidney dysfunction.

ACEFLAM 100mg Contraindications ACEFLAM 100mg

ACEFLAM should not be used in the following cases:

• Known hypersensitivity to Aceclofenac or any NSAID component.
• History of asthma, urticaria, or allergic reactions triggered by NSAIDs.
• Active peptic ulcer or gastrointestinal bleeding.
• Severe liver, kidney, or heart failure.
• Third trimester of pregnancy due to risk of fetal harm and labor complications.
• Breastfeeding mothers unless clearly indicated by the healthcare provider.
• Children and adolescents under 18 years without specialist approval.

Consult your physician before starting ACEFLAM if you have any pre-existing medical conditions or if you are pregnant or breastfeeding.

Storage of ACEFLAM 100mg

Proper storage of ACEFLAM 100 mg is vital to maintain its effectiveness and safety:

• Store at room temperature below 25°C (77°F).
• Keep away from moisture, heat, and direct sunlight.
• Keep the tablets in their original blister pack until use to protect from environmental exposure.
• Keep out of reach of children and pets to avoid accidental ingestion.
• Do not use the medication past its expiry date.
• If the tablets appear discolored, damaged, or altered, do not consume them.

Dispose of expired or unused medicine safely by returning it to a pharmacy or following local disposal regulations.