Anastradox 1 mg Tablet/Film coated

What is Anastradox 1 mg

ANASTRADOX 1mg is a film-coated tablet containing Anastrozole, a highly selective, non-steroidal aromatase inhibitor. It is primarily used in the management of hormone receptor-positive breast cancer in postmenopausal women. Breast cancer cells in many cases require estrogen for growth, and ANASTRADOX works by significantly lowering estrogen levels in the body, thus slowing or stopping the growth of these cancerous cells.

• Generic Name: Anastrozole
• Formulation: Film-coated tablet
• Primary Indication: Treatment of early and advanced hormone receptor-positive breast cancer in postmenopausal women.
• Use in Therapy: ANASTRADOX is often prescribed after surgery or in advanced disease stages to help reduce the risk of cancer recurrence or progression.

Because of its high selectivity and potency, ANASTRADOX has become a cornerstone in hormone therapy for breast cancer, offering better outcomes and a different side effect profile compared to older agents like tamoxifen.

How to use Anastradox 1 mg

Using ANASTRADOX 1mg correctly is essential to achieving maximum therapeutic benefits while minimizing potential side effects:

• Administration: Take ANASTRADOX orally, once daily, at the same time each day, with or without food.
• Swallowing: The tablet should be swallowed whole with a glass of water; do not crush, chew, or split the tablet.
• Missed Dose: If a dose is missed, take it as soon as possible. If it is close to the next scheduled dose, skip the missed dose and resume the regular schedule. Do not double doses.
• Treatment Duration: Therapy duration is often several years, depending on the oncologist’s recommendation and patient response.
• Monitoring: Regular monitoring for bone health, cholesterol levels, and signs of disease recurrence is advised throughout treatment.

Strict adherence to the dosing schedule and regular medical follow-ups greatly influence the success of treatment with ANASTRADOX 1mg. Patients should not discontinue therapy without consulting their physician, even if they feel well.

Mode of Action Anastradox 1 mg

ANASTRADOX 1mg acts on a crucial pathway responsible for estrogen production:

• Inhibition of Aromatase: Aromatase is the enzyme responsible for converting androgens (male hormones) into estrogens (female hormones) in peripheral tissues.
• Reduction of Estrogen Levels: By inhibiting aromatase, Anastrozole drastically reduces the circulating estrogen levels in postmenopausal women.
• Impact on Cancer Cells: Many breast cancer cells depend on estrogen for proliferation. Reducing estrogen slows their growth and can lead to tumor regression.
• Selective Mechanism: Anastrozole targets only aromatase and does not interfere significantly with other hormone pathways like glucocorticoids or mineralocorticoids.

This highly selective action makes ANASTRADOX 1mg an effective and safer alternative to other hormonal therapies in estrogen-dependent breast cancer treatment.

Anastradox 1 mg Interactions Anastradox 1 mg

Several drug interactions should be considered when taking ANASTRADOX 1mg to avoid reduced efficacy or increased side effects:

• Estrogen-Containing Products: Hormone replacement therapy or any medication containing estrogen can counteract the effects of Anastrozole and should be avoided.
• Tamoxifen: Concomitant use is not recommended as tamoxifen may reduce plasma concentrations of Anastrozole.
• Anticoagulants: Monitor carefully if used alongside blood thinners, although significant interactions are rare.
• CYP450 Modulators: Drugs that affect cytochrome P450 enzymes (e.g., rifampin) may theoretically alter Anastrozole metabolism, although significant clinical impacts are uncommon.

Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking to prevent any harmful interactions with ANASTRADOX 1mg.

Dosage of Anastradox 1 mg

The standard dosage guidelines for ANASTRADOX 1mg ensure its safe and effective use:

• Standard Dose: 1 mg orally once a day.
• Food Intake: It can be taken with or without food.
• Special Populations: No dosage adjustment is typically needed for elderly patients or those with mild to moderate hepatic or renal impairment.
• Duration: Treatment is usually continued for 5 years in adjuvant therapy or until disease progression in metastatic disease.

Patients should never adjust their dosage without medical advice. Maintaining the correct daily dosage is vital to prevent cancer recurrence and manage disease effectively with ANASTRADOX 1mg.

Possible side effects of Anastradox 1 mg

Like all medications, ANASTRADOX 1mg may cause side effects, though not everyone experiences them:

• Common Side Effects: Hot flashes, joint pain, stiffness, weakness, and headache.
• Bone Effects: Long-term use can lead to osteoporosis or fractures due to decreased bone mineral density.
• Cardiovascular Issues: Slight increase in the risk of ischemic heart disease in some patients.
• Gastrointestinal Problems: Nausea, vomiting, diarrhea, or constipation.
• Rare but Serious: Liver dysfunction, allergic reactions like rash, or swelling.

Regular monitoring and preventive measures, such as bone density tests and cardiovascular risk management, can help mitigate the risks associated with long-term use of ANASTRADOX 1mg.

Anastradox 1 mg Contraindications Anastradox 1 mg

ANASTRADOX 1mg should not be used in certain populations where the risks outweigh the benefits:

• Premenopausal Women: Ineffective as ovarian estrogen production is not suppressed by aromatase inhibitors.
• Pregnancy and Breastfeeding: Contraindicated due to potential harm to the fetus or infant.
• Allergy: Patients with known hypersensitivity to Anastrozole or any excipients should avoid use.
• Severe Hepatic Impairment: Caution is needed due to altered drug metabolism.

A thorough pre-treatment assessment should be conducted to ensure that ANASTRADOX 1mg is an appropriate therapy for the patient’s clinical situation.

Storage of Anastradox 1 mg

Proper storage ensures the potency and safety of ANASTRADOX 1mg:

• Temperature: Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Protection: Keep the medication in its original HDPE bottle, tightly closed, away from moisture and direct light.
• Avoid Freezing: Do not refrigerate or freeze the medication.
• Child Safety: Store out of reach of children to prevent accidental ingestion.
• Expiry: Check the expiry date and dispose of expired tablets safely according to local regulations.

Adhering to the recommended storage guidelines helps maintain the effectiveness and ensures patient safety when using ANASTRADOX 1mg.