AMYDRAMINE PAEDIATRIC Syrup (Alcohol-free)

What is AMYDRAMINE PAEDIATRIC

AMYDRAMINE PAEDIATRIC is an alcohol-free syrup formulation containing Diphenhydramine Hydrochloride, an antihistamine commonly used in children for relieving symptoms associated with allergies, hay fever, and the common cold. It is designed specifically for pediatric use, ensuring a safe, gentle, and effective treatment for younger patients.

• Generic Name: Diphenhydramine Hydrochloride
• Formulation: Syrup (alcohol-free, child-friendly taste)
• Primary Uses: Relief from sneezing, runny nose, itchy/watery eyes, itchy throat, and coughing.
• Additional Uses: It may also be used to manage mild cases of insomnia in children or allergic skin reactions.

This medication provides parents and caregivers a trusted option to help soothe a child's discomfort from various allergic and cold-related symptoms.

How to use AMYDRAMINE PAEDIATRIC

Correct usage of AMYDRAMINE PAEDIATRIC is essential to maximize its therapeutic benefit while minimizing any risks:

• Route of Administration: Oral syrup.
• Measuring Dose: Use a medical measuring spoon or dosing syringe, not a household spoon, to ensure the correct dose.
• Timing: Administer with or without food; if stomach upset occurs, giving it with food or milk is recommended.
• Frequency: Generally every 4 to 6 hours as needed, but no more than the maximum recommended daily dose.
• Missed Dose: If a dose is missed, administer as soon as possible, but skip it if it's almost time for the next scheduled dose; do not double doses.
• Duration: Use only for short-term treatment unless otherwise directed by a healthcare professional.

Always follow the doctor’s instructions or the dosing guidelines on the packaging to ensure safe use, especially for young children.

Mode of Action AMYDRAMINE PAEDIATRIC

AMYDRAMINE PAEDIATRIC works by altering the body's histamine response and calming hypersensitive reactions:

• Histamine Blockade: Diphenhydramine is a first-generation H1-receptor antagonist, meaning it blocks the action of histamine — a chemical that the body produces during allergic reactions.
• Effect on Symptoms: By inhibiting histamine, it reduces sneezing, itching, watery eyes, and other allergy-related symptoms.
• Sedative Properties: It crosses the blood-brain barrier, causing mild sedation, which can be beneficial for children experiencing restlessness from allergies or colds.

Through these actions, AMYDRAMINE PAEDIATRIC provides both symptomatic relief and comfort, particularly during nighttime when symptoms can disrupt a child's sleep.

AMYDRAMINE PAEDIATRIC Interactions AMYDRAMINE PAEDIATRIC

Care must be taken when AMYDRAMINE PAEDIATRIC is administered with other medications, as interactions can affect safety and efficacy:

• Central Nervous System Depressants: Concurrent use with sedatives, tranquilizers, or alcohol can amplify drowsiness and impair cognitive or motor functions.
• MAO Inhibitors: Using diphenhydramine with monoamine oxidase inhibitors can prolong and intensify the anticholinergic and sedative effects, which may be dangerous.
• Other Antihistamines: Combining multiple antihistamines (even topical ones) can lead to overdose symptoms such as confusion, extreme drowsiness, or seizures.
• Asthma Medications: Some bronchodilators and anticholinergic drugs may have additive anticholinergic side effects with diphenhydramine.

Always inform your healthcare provider about all medicines the child is taking, including herbal and over-the-counter products, to prevent harmful interactions.

Dosage of AMYDRAMINE PAEDIATRIC

Proper dosing is critical to ensure efficacy while avoiding side effects or toxicity:

• Children aged 2 to 6 years: As directed by a physician; typically lower doses are recommended.
• Children aged 6 to 12 years: Usual dosage is around 5 mL to 10 mL every 4–6 hours as needed, but must not exceed the recommended total daily dose.
• Older children (over 12 years): Follow specific pediatric dosing or transition to adult formulations as appropriate.
• Maximum Dosing: Generally not more than 6 doses in 24 hours unless under strict medical supervision.

Parental supervision is essential, and if the child’s condition does not improve within a few days, or if it worsens, medical advice should be sought immediately.

Possible side effects of AMYDRAMINE PAEDIATRIC

As with all medications, AMYDRAMINE PAEDIATRIC may cause side effects, though not everyone will experience them:

• Common Side Effects: Drowsiness, dizziness, dry mouth, constipation, blurred vision.
• Less Common Side Effects: Excitability (especially in young children), nervousness, difficulty sleeping.
• Serious Side Effects: Fast or irregular heartbeat, severe dizziness, difficulty urinating, or mental/mood changes (such as confusion or hallucinations).
• Allergic Reactions: Rare but serious, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.

If any serious side effects or signs of an allergic reaction occur, discontinue use and seek immediate medical attention.

AMYDRAMINE PAEDIATRIC Contraindications AMYDRAMINE PAEDIATRIC

Certain conditions make the use of AMYDRAMINE PAEDIATRIC inappropriate or dangerous:

• Newborns or Premature Infants: Not recommended for use in very young infants due to increased risk of serious side effects.
• MAOI Therapy: Contraindicated if the child is taking monoamine oxidase inhibitors.
• Lower Respiratory Disease: Conditions like asthma or chronic bronchitis can be exacerbated by diphenhydramine.
• Hypersensitivity: Children allergic to diphenhydramine or any component of the formulation should not use this medicine.

Before starting treatment, a full medical history should be discussed with a healthcare provider to ensure safety.

Storage of AMYDRAMINE PAEDIATRIC

Correct storage ensures the medicine remains safe and effective for its intended use:

• Temperature: Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Moisture Protection: Keep the bottle tightly closed and protect from excessive moisture.
• Light Protection: Store away from direct sunlight.
• Child Safety: Always keep out of reach of children to prevent accidental overdose.
• Expiration: Do not use after the expiration date indicated on the bottle.

Proper storage practices maintain the integrity and effectiveness of the syrup throughout its shelf life.