AMYDRAMINE - II Syrup (Sugar-free)

What is AMYDRAMINE - II

AMYDRAMINE - II is a sugar-free oral syrup containing Diphenhydramine Hydrochloride, primarily used as an antihistamine and cough suppressant. It is designed to relieve allergy symptoms such as runny nose, sneezing, and itchy eyes, as well as dry cough caused by throat or airway irritation. The sugar-free formulation makes it particularly suitable for diabetic patients and those monitoring their sugar intake.

• Generic Name: Diphenhydramine Hydrochloride
• Form: Sugar-free syrup
• Primary Indications: Treatment of allergic reactions, dry cough, and symptoms of the common cold.
• Secondary Uses: Can also act as a mild sedative to aid sleep when cough or allergies interfere with rest.

AMYDRAMINE - II offers effective multi-symptom relief and is appropriate for both children and adults under the supervision of a healthcare provider.

How to use AMYDRAMINE - II

Correct usage of AMYDRAMINE - II is critical for achieving the best therapeutic outcomes while minimizing side effects:

• Administration: Taken orally using a medical measuring device (syringe, cup, or spoon).
• Timing: Administered every 4 to 6 hours as needed, without exceeding the maximum daily dosage.
• Shake Well: Shake the bottle thoroughly before each use to ensure uniform distribution of the medication.
• With or Without Food: May be taken with food if gastrointestinal upset occurs.
• Hydration: Adequate fluid intake is encouraged to assist in mucus clearance from the respiratory tract.

Always follow the healthcare provider's recommendations or the instructions provided on the packaging. Never use kitchen utensils for measurement to avoid incorrect dosing, and do not exceed the recommended dose to prevent serious side effects.

Mode of Action AMYDRAMINE - II

AMYDRAMINE - II works through multiple mechanisms to provide symptom relief:

• Histamine Blockade: Diphenhydramine binds to H1 histamine receptors, preventing histamine-mediated allergic responses such as sneezing, itching, and runny nose.
• Cough Suppression: It acts centrally on the medullary cough center in the brain to suppress the cough reflex.
• Sedative Effect: Because Diphenhydramine crosses the blood-brain barrier, it exerts mild sedative effects, promoting restful sleep during illness.

Through these effects, AMYDRAMINE - II effectively reduces the discomfort associated with allergies and respiratory irritation, enhancing overall patient well-being.

AMYDRAMINE - II Interactions AMYDRAMINE - II

Drug interactions can alter the action of AMYDRAMINE - II, sometimes leading to increased side effects or reduced effectiveness:

• Central Nervous System Depressants: Concurrent use with alcohol, benzodiazepines, opioids, or other sedatives can result in excessive drowsiness or respiratory depression.
• Monoamine Oxidase Inhibitors (MAOIs): Using AMYDRAMINE - II with MAOIs can prolong and intensify its effects, leading to severe side effects such as hallucinations or dangerously low blood pressure.
• Other Antihistamines: Combining with additional antihistamines increases the risk of overdose and intensified anticholinergic effects (e.g., dry mouth, urinary retention).
• Anticholinergic Agents: Co-administration with drugs like atropine can exacerbate side effects such as blurred vision and constipation.

It is important to disclose all medications, herbal products, and supplements to the healthcare provider before starting AMYDRAMINE - II.

Dosage of AMYDRAMINE - II

The dosage of AMYDRAMINE - II must be tailored to the patient’s age, weight, and medical condition:

• Adults and Children over 12 years: 10 mL (two teaspoons) every 4–6 hours. Do not exceed 6 doses (60 mL) in 24 hours.
• Children 6–12 years: 5 mL (one teaspoon) every 4–6 hours, with a maximum of 6 doses in 24 hours.
• Children under 6 years: Use only under strict medical supervision.

Always use the dosing cup provided and avoid exceeding the recommended daily dose, as overdose can result in serious complications like excessive sedation, seizures, or respiratory depression.

Possible side effects of AMYDRAMINE - II

While AMYDRAMINE - II is generally safe when used as directed, side effects can occur:

• Common Side Effects: Drowsiness, dizziness, dry mouth, nausea, constipation, and blurred vision.
• Less Common Side Effects: Excitability (especially in children), nervousness, tremor, or difficulty urinating.
• Serious Reactions: Irregular heartbeat, hallucinations, severe drowsiness, confusion, or seizures.
• Allergic Reactions: Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing.

In case of any severe or persistent side effects, seek immediate medical attention. Mild symptoms often resolve as the body adjusts to the medication.

AMYDRAMINE - II Contraindications AMYDRAMINE - II

AMYDRAMINE - II should not be used under certain conditions:

• Neonates and Infants: Should not be used in newborns and premature infants due to the risk of respiratory depression.
• MAOI Use: Contraindicated within 14 days of stopping a monoamine oxidase inhibitor.
• Hypersensitivity: Avoid in patients with known allergies to Diphenhydramine or any ingredients in the formulation.
• Lower Respiratory Tract Diseases: Not recommended in patients with asthma or chronic obstructive pulmonary disease unless under medical advice.

Careful patient history and assessment are crucial to avoid adverse outcomes with AMYDRAMINE - II.

Storage of AMYDRAMINE - II

Proper storage is vital to maintain the quality and safety of AMYDRAMINE - II:

• Temperature: Store at room temperature (20°C to 25°C or 68°F to 77°F).
• Protection: Protect from light, heat, and moisture.
• Container: Keep the bottle tightly closed when not in use.
• Child Safety: Store out of reach of children to prevent accidental ingestion.
• Shelf Life: Discard the syrup after the expiration date or as advised on the label.

Do not freeze the syrup. Proper storage ensures the medication retains its effectiveness and safety throughout its intended use period.