PANGEN 400mg Topical Powder/Dusting

What is PANGEN 400mg

PANGEN 400mg is a sterile topical powder formulation composed of non-denatured native collagen. It is designed to promote wound healing by providing a biologically active matrix that supports cellular regeneration and modulates the wound environment. This topical dusting powder is particularly suitable for lightly to moderately exuding wounds, surgical incisions, ulcers, and abrasions where a dry collagen application is beneficial.

• Form: Topical Powder (Dusting form)
• Strength: 400mg per bottle
• Generic Ingredient: Non-denatured native collagen
• Packaging: 400mg bottle × 10 units
• Primary Indications:
  • Diabetic foot ulcers
  • Pressure ulcers
  • Venous leg ulcers
  • Post-surgical wounds
  • Minor cuts, abrasions, and burns

PANGEN 400mg facilitates a moist wound healing environment while absorbing excess exudate, supporting tissue repair and granulation.

How to use PANGEN 400mg

Correct application of PANGEN 400mg Topical Powder is essential to ensure optimal therapeutic benefits. It is generally used in both inpatient and outpatient wound management under sterile conditions.

• Preparation:
  • Cleanse the wound using sterile saline or an appropriate wound cleanser
  • Dry the surrounding skin to facilitate adhesion of any secondary dressing
• Application Instructions:
  • Gently tap the bottle to apply a light dusting of PANGEN powder directly over the wound surface
  • A thin, even layer is sufficient—do not over-apply
  • Cover with a secondary dressing such as a film or hydrocolloid to retain moisture and protect the area
• Frequency:
  • Typically reapplied once daily or with each dressing change
  • In heavily exudating wounds, reapplication may be more frequent as advised by a healthcare provider

Always follow sterile technique and medical advice for frequency and duration of use. The powder should not be used internally or on mucosal surfaces unless directed by a physician.

Mode of Action PANGEN 400mg

PANGEN 400mg acts through the physiological functions of native collagen, playing a pivotal role in wound healing. The native, triple-helical structure of collagen is preserved, which allows it to remain biologically active at the site of application.

• Protease Modulation:
  • Collagen binds and neutralizes matrix metalloproteinases (MMPs), which are elevated in chronic wounds and delay healing
  • This reduces excessive proteolytic activity and restores the wound's healing balance
• Cellular Support:
  • Acts as a biological scaffold, encouraging the migration of fibroblasts and keratinocytes
  • Promotes new tissue formation and capillary growth
• Moisture Balance:
  • Absorbs exudate while maintaining a moist environment favorable for healing

By integrating into the wound matrix, PANGEN 400mg helps transform a chronic or stagnant wound into one that actively progresses through the healing phases.

PANGEN 400mg Interactions PANGEN 400mg

Since PANGEN 400mg is a topical product and acts locally, systemic interactions are highly unlikely. However, some precautions regarding topical compatibility and co-use with other agents are important.

• Incompatible Agents:
  • Do not use with hydrogen peroxide, povidone-iodine, or other oxidative agents—they can denature collagen
  • Avoid concurrent use with enzymatic debriders unless prescribed, as these may degrade collagen structure
• Compatible Products:
  • Can be used with most secondary dressings (e.g., film, hydrocolloid, foam)
  • May be combined with systemic antibiotics or antiseptics when infection is present
• Drug Interactions:
  • No known interactions with oral or injectable medications
  • Safe to use in patients with complex medication regimens, including anticoagulants or immunosuppressants

For best outcomes, avoid mixing with substances that could alter collagen's structure or impair its function. Consult a healthcare professional when using with other wound care agents.

Dosage of PANGEN 400mg

Dosage of PANGEN 400mg refers to the frequency and extent of topical application, not systemic intake. The amount required varies based on the wound's size, depth, and exudate level.

• Typical Application:
  • Apply a light dusting (enough to thinly coat the wound) once daily
  • For large wounds, ensure uniform coverage without excess build-up
• Reapplication Frequency:
  • Daily dressing changes or more frequently if the wound is heavily exudative
  • Reapply after wound irrigation or cleaning procedures
• Maximum Usage:
  • No strict upper limit when used correctly under sterile conditions
  • Consult with a wound care specialist for chronic wounds needing prolonged use

PANGEN 400mg can be safely applied as part of a structured wound care protocol. Do not exceed recommended use without medical oversight, especially in immunocompromised patients or those with large, open wounds.

Possible side effects of PANGEN 400mg

While PANGEN 400mg is generally safe and well-tolerated, especially due to its topical nature, certain local reactions may occur, particularly in sensitive individuals.

• Common Local Effects:
  • Mild redness or irritation around the application site
  • Itching or transient stinging after application
• Rare but Possible Side Effects:
  • Allergic reaction to bovine-derived collagen (manifested as rash, swelling, or discomfort)
  • Secondary infection due to improper wound hygiene or delayed dressing changes
• Precautions:
  • Discontinue use if persistent erythema, swelling, or discharge occurs
  • Report signs of systemic infection (fever, chills, increased wound drainage) immediately

If any adverse reaction develops, consult your healthcare provider. Patch testing may be advisable for patients with a known history of topical allergies.

PANGEN 400mg Contraindications PANGEN 400mg

Although PANGEN 400mg is safe for most individuals, it should not be used in certain conditions where its use could cause harm or reduced efficacy.

• Absolute Contraindications:
  • Hypersensitivity to collagen or any component of the product
  • Known allergy to bovine-derived products
• Relative Contraindications:
  • Use on infected wounds without concurrent antimicrobial treatment
  • Application to actively bleeding wounds unless under medical supervision
• Use with Caution:
  • In patients with autoimmune disorders affecting collagen (e.g., lupus erythematosus)
  • On wounds near mucosal areas (e.g., perianal or perioral wounds) unless instructed

Always consult a healthcare provider for complex wounds or underlying health conditions that may impact wound healing or product safety.

Storage of PANGEN 400mg

Maintaining the sterility and integrity of PANGEN 400mg is essential to ensure its effectiveness. Proper storage conditions should be adhered to both in clinical and home settings.

• Temperature:
  • Store at room temperature, ideally between 15°C and 25°C (59°F to 77°F)
• Moisture Protection:
  • Keep the bottle tightly closed when not in use
  • Avoid exposure to high humidity or water contamination
• Sterility Maintenance:
  • Do not use if the seal is broken or the bottle appears damaged
  • Use within the expiry date mentioned on the packaging
• Disposal:
  • Discard unused powder after the recommended period once opened
  • Dispose of used product and containers in accordance with local medical waste guidelines

Proper storage not only extends the shelf life but also ensures the safety and efficacy of PANGEN 400mg during wound management.