PANADOL MIGRAINE Tablets/Film-coated

What is PANADOL MIGRAINE

PANADOL MIGRAINE is a specially formulated, over-the-counter medication used for the relief of migraine headaches. It contains a triple-action combination of:

• Aspirin (250 mg) – a non-steroidal anti-inflammatory drug (NSAID)
• Paracetamol (250 mg) – an analgesic and antipyretic
• Caffeine (65 mg) – a stimulant that enhances pain relief

This unique combination works synergistically to target multiple pain pathways involved in migraines, offering fast and effective relief. It comes in film-coated tablet form and is packaged in bottles of 50 tablets, making it convenient for those who experience frequent or recurrent migraines.

Common uses of Panadol Migraine include:

• Treatment of migraine headaches (with or without aura)
• Relief of associated symptoms such as nausea, light sensitivity, and throbbing head pain
• Management of tension-type headaches (secondary use)

Unlike standard pain relievers, Panadol Migraine is specifically designed to address the neurological and vascular components of migraine attacks. It is recommended for adults and adolescents over the age of 12, under medical supervision if used frequently.

How to use PANADOL MIGRAINE

Using Panadol Migraine properly ensures effective relief from migraine symptoms and reduces the risk of side effects or overuse headaches. The film-coated tablets are designed for oral administration.

• Route: Oral – swallow tablets whole with water.
• Food: Can be taken with or without food. Taking with food may help reduce gastrointestinal upset due to aspirin.

Instructions:

• Take the tablets at the first sign of a migraine for best results.
• Swallow tablets whole; do not crush or chew.
• Drink a full glass of water to help with absorption and minimize stomach irritation.

What to avoid while using Panadol Migraine:

• Avoid consuming large amounts of caffeine from other sources (coffee, tea, energy drinks) to reduce risk of overstimulation or jitteriness.
• Do not use with other NSAIDs or paracetamol-containing medications to avoid overdose.
• Refrain from using this product more than recommended. Overuse may lead to rebound (medication-overuse) headaches.

If symptoms persist for more than a few days or worsen, consult a healthcare provider. Frequent migraines may require preventive treatment or diagnostic evaluation.

Mode of Action PANADOL MIGRAINE

Panadol Migraine combines three active ingredients that target different mechanisms contributing to migraine pain. Their complementary actions provide enhanced relief and faster symptom control.

• Aspirin (250 mg):
  • Acts as an NSAID by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes.
  • Reduces the production of prostaglandins—chemicals that cause inflammation, pain, and swelling.
  • Improves blood flow by inhibiting platelet aggregation, which can be beneficial in vascular headaches.
• Paracetamol (250 mg):
  • Works centrally to reduce pain and fever, likely through COX inhibition in the brain.
  • Has minimal gastrointestinal side effects compared to NSAIDs, making the combination tolerable.
• Caffeine (65 mg):
  • Acts as a central nervous system stimulant by blocking adenosine receptors.
  • Enhances the analgesic effects of aspirin and paracetamol by improving drug absorption and pain perception.
  • Vasoconstriction effects can counteract the vasodilation phase of migraines.

Together, these agents address the multiple pain pathways involved in migraine—including inflammation, nerve sensitization, and vascular changes—making Panadol Migraine an effective option for acute migraine attacks.

PANADOL MIGRAINE Interactions PANADOL MIGRAINE

Like all combination medications, Panadol Migraine may interact with other drugs, potentially altering effectiveness or increasing risks. It is important to be aware of these interactions.

• Anticoagulants (e.g., warfarin): Aspirin may enhance bleeding risk by inhibiting platelet function. Monitor INR closely.
• SSRIs and SNRIs: Combined with aspirin, there may be an increased risk of gastrointestinal bleeding.
• Other NSAIDs or salicylates: Increases the risk of stomach irritation, ulcers, or bleeding. Avoid concurrent use.
• Other paracetamol-containing products: Risk of overdose. Ensure total daily paracetamol dose does not exceed 4000 mg.
• Methotrexate: Aspirin may reduce renal clearance of methotrexate, increasing toxicity risk.
• Diuretics and antihypertensives: NSAIDs like aspirin may reduce effectiveness, particularly in patients with hypertension.
• Alcohol: Combined with aspirin or paracetamol, alcohol can increase risk of liver and gastric damage.

General Advice:

• Always consult a healthcare professional before using Panadol Migraine with any prescription, OTC, or herbal medicines.
• Check labels of other products to avoid ingredient duplication.

Dosage of PANADOL MIGRAINE

The dosage of Panadol Migraine should be strictly followed to ensure effective treatment and to avoid potential toxicity.

• Adults and Adolescents ≥12 years:
  • Take 2 tablets with water at the onset of migraine symptoms.
  • If needed, you may take another 2 tablets after at least 4–6 hours.
  • Do not exceed 6 tablets in 24 hours.
• Children under 12 years: Not recommended due to caffeine and aspirin content.

Important Guidelines:

• Do not use more frequently than directed.
• Avoid using for more than 3 days in a row without medical supervision to prevent medication-overuse headaches.
• Do not exceed the maximum daily dose of 6 tablets.

Missed Dose: This medication is used as needed for pain. If pain returns after the first dose, wait at least 4–6 hours before taking another dose. Do not double up to compensate for a missed dose.

Consult your healthcare provider if your migraines are frequent, severe, or change in pattern, as this may indicate an underlying issue requiring different management.

Possible side effects of PANADOL MIGRAINE

While generally well-tolerated, Panadol Migraine can cause side effects in some individuals, especially if taken in excessive amounts or in sensitive populations.

• Common Side Effects:
  • Gastrointestinal upset (nausea, abdominal pain)
  • Nervousness, restlessness (from caffeine)
  • Heartburn or mild indigestion (from aspirin)
• Less Common/Rare Side Effects:
  • Allergic reactions: rash, hives, facial swelling
  • Insomnia or jitteriness (especially in caffeine-sensitive individuals)
  • Bleeding or bruising (due to aspirin's blood-thinning effect)

Serious Adverse Effects:

• Gastrointestinal bleeding or ulcers (black/tarry stools, vomiting blood)
• Liver damage (especially with paracetamol overdose)
• Severe allergic reaction or anaphylaxis (rare)

Seek immediate medical attention if you experience symptoms of overdose, such as nausea, vomiting, confusion, or yellowing of the skin/eyes. Even if you feel fine initially, paracetamol overdose can have delayed but serious effects.

PANADOL MIGRAINE Contraindications PANADOL MIGRAINE

There are several medical situations where Panadol Migraine should not be used, due to the presence of aspirin, paracetamol, and caffeine.

• Hypersensitivity: Known allergy to aspirin, paracetamol, caffeine, or NSAIDs.
• Active peptic ulcer disease or gastrointestinal bleeding
• Severe liver impairment or liver disease
• Severe kidney disease
• Bleeding disorders (e.g., hemophilia)
• Children under 12 years: Aspirin may cause Reye’s syndrome in children with viral illnesses.
• Pregnancy and breastfeeding:
  • Not recommended, especially during the third trimester.
  • Caffeine and aspirin may affect fetal development or pass into breast milk.

If you have chronic medical conditions or are on long-term medications, consult a physician before using Panadol Migraine.

Storage of PANADOL MIGRAINE

Proper storage ensures Panadol Migraine maintains its effectiveness and safety until its expiration date.

• Temperature: Store below 25°C (77°F). Avoid excessive heat or freezing temperatures.
• Moisture: Keep tablets in the original container with the lid tightly closed. Store in a dry place.
• Light: Protect from direct sunlight.
• Child Safety: Store out of reach and sight of children to prevent accidental ingestion.

Disposal:

• Do not use after the expiration date printed on the bottle.
• Dispose of expired or unused tablets safely, preferably through a pharmacy take-back program.

Do not flush medication down the toilet or pour into drains unless instructed. Improper disposal can harm the environment.