PANADOL COLD + FLU ALL IN ONE Tablets/Film-coated

What is PANADOL COLD + FLU ALL IN ONE

PANADOL COLD + FLU ALL IN ONE is a multi-symptom relief medication designed to address common cold and flu symptoms. It comes in the form of film-coated tablets and is formulated with three active ingredients:

• Paracetamol (Acetaminophen): A widely used analgesic and antipyretic, it helps reduce fever and alleviate mild to moderate pain such as headaches, sore throat, and body aches.
• Phenylephrine: A decongestant that reduces nasal congestion by constricting blood vessels in the nasal passages.
• Guaifenesin: An expectorant that helps loosen and thin mucus in the airways, making it easier to cough up and clear from the respiratory tract.

This combination makes PANADOL COLD + FLU ALL IN ONE an effective choice for managing a wide range of flu-like symptoms, including:

• Fever
• Nasal congestion
• Sore throat
• Chest congestion
• Sinus pressure and headaches
• Cough associated with mucus

It is a convenient over-the-counter remedy that addresses multiple symptoms with a single formulation, suitable for short-term use in adults and adolescents over a certain age (typically 12+). Always follow medical advice or product labeling for specific use instructions.

How to use PANADOL COLD + FLU ALL IN ONE

Proper usage ensures effectiveness and minimizes potential side effects. Here's how to use PANADOL COLD + FLU ALL IN ONE responsibly:

• Form: Oral film-coated tablet
• Swallow whole: Do not crush or chew the tablet. Take it with a glass of water.
• With or without food: Can be taken on an empty stomach or after meals, depending on your tolerance.

General instructions:

• Adults and children aged 12 years and over: Typically 2 tablets every 4–6 hours as needed for symptom relief.
• Maximum dose: Do not exceed 8 tablets in 24 hours.
• Duration: Do not take for more than 7 days without medical advice.

Important usage notes:

• Always read the label and follow the instructions provided with the product.
• If symptoms persist or worsen after 3–5 days, consult a healthcare provider.
• Keep track of all medications you take to avoid exceeding the recommended dose of paracetamol, which can be harmful to the liver.
• Do not take with other cold or flu medications unless advised by a physician, to prevent ingredient duplication.

Mode of Action PANADOL COLD + FLU ALL IN ONE

This medicine uses a triple-action formula targeting various cold and flu symptoms through its three active components. Each works via a specific pharmacological pathway:

• Paracetamol:
  • Acts on the hypothalamus to reduce fever (antipyretic effect).
  • Inhibits prostaglandin synthesis in the central nervous system to provide analgesic (pain relief) effects.
• Phenylephrine:
  • A sympathomimetic amine that acts as a selective α1-adrenergic receptor agonist.
  • Causes vasoconstriction of blood vessels in the nasal mucosa, reducing swelling and congestion.
• Guaifenesin:
  • Reduces the viscosity of bronchial secretions.
  • Enhances mucociliary clearance, making it easier to expel mucus through coughing.

Combined, these actions provide relief from fever, pain, congestion, and productive cough—delivering broad-spectrum symptomatic relief.

PANADOL COLD + FLU ALL IN ONE Interactions PANADOL COLD + FLU ALL IN ONE

As a combination medication, PANADOL COLD + FLU ALL IN ONE may interact with a variety of drugs. Awareness of these interactions is critical for safe use:

• Other Paracetamol-containing products: Risk of overdose and liver toxicity.
• Monoamine Oxidase Inhibitors (MAOIs): Concurrent use with phenylephrine can cause hypertensive crisis. Avoid use within 14 days of stopping MAOIs.
• Tricyclic Antidepressants: May enhance the hypertensive effect of phenylephrine.
• Beta-blockers and antihypertensive drugs: Phenylephrine may reduce the effectiveness of these medications.
• Warfarin and other anticoagulants: Chronic use of paracetamol may increase bleeding risk.
• Alcohol: Increases risk of liver damage when taken with paracetamol.
• Sedatives or CNS depressants: Guaifenesin may potentiate their effects in some users.

Always consult a pharmacist or physician before combining this product with any other medications or supplements.

Dosage of PANADOL COLD + FLU ALL IN ONE

Correct dosage is vital for the efficacy and safety of this medicine. Here are the standard dosage guidelines:

• Adults and children aged 12 years and over: Take 2 tablets every 4–6 hours as needed.
• Maximum daily dose: Do not exceed 8 tablets in 24 hours.

Special populations:

• Children under 12: Not recommended due to potential risks and inappropriate dosage.
• Elderly: Use with caution; monitor for increased sensitivity to side effects.
• Patients with liver or kidney impairment: Use under medical supervision; dose adjustments may be required.

Missed Dose: If you miss a dose, take it as soon as you remember. If it's close to the next scheduled dose, skip the missed one—never double up.

Possible side effects of PANADOL COLD + FLU ALL IN ONE

Most people tolerate this medication well when used appropriately. However, side effects may occur. These include:

• Common:
  • Nausea or stomach upset
  • Headache
  • Nervousness or restlessness (due to phenylephrine)
• Less common but serious:
  • Allergic reactions: rash, itching, swelling, or difficulty breathing
  • High blood pressure or palpitations (especially in those with heart conditions)
  • Liver damage from paracetamol overuse
• Rare:
  • Confusion or dizziness
  • Insomnia or agitation
  • Urinary retention, particularly in males with prostate issues

If you experience any unusual or severe symptoms, stop the medication and seek immediate medical attention.

PANADOL COLD + FLU ALL IN ONE Contraindications PANADOL COLD + FLU ALL IN ONE

This product is contraindicated in certain individuals due to the risk of adverse effects. Do not use this medication in the following cases:

• Known hypersensitivity: Allergy to paracetamol, phenylephrine, guaifenesin, or any excipient in the formulation.
• Severe hypertension or cardiovascular disease: Phenylephrine can exacerbate these conditions.
• Severe hepatic impairment: Paracetamol metabolism is impaired, increasing risk of toxicity.
• Concurrent use of MAO inhibitors: Risk of hypertensive crisis. A 14-day washout period is advised before starting this medicine.
• Thyrotoxicosis or hyperthyroidism: May be aggravated by sympathomimetic effects of phenylephrine.
• Glaucoma or urinary retention: Especially in males with prostatic hypertrophy, due to phenylephrine’s effects on smooth muscle.

Storage of PANADOL COLD + FLU ALL IN ONE

Proper storage maintains the medication’s effectiveness and safety. Follow these storage guidelines:

• Temperature: Store below 25°C (77°F).
• Humidity: Keep in a dry place, away from moisture and direct sunlight.
• Packaging: Keep the tablets in their original blister packaging until use to protect from air and moisture.
• Keep out of reach of children: Always store in a secure location to prevent accidental ingestion.

Disposal: Do not flush unused tablets down the toilet. Return them to a pharmacy or follow local disposal regulations.