PANADOL Cold & Flu Tablets

What is PANADOL Cold & Flu

PANADOL Cold & Flu Tablets are a combination medicine designed to relieve symptoms associated with the common cold and influenza. It comes in a pack of 24 tablets (2 blisters of 12) and includes the active ingredient Paracetamol, among others depending on the formulation (e.g., with decongestants or antihistamines).

• Generic Ingredient: Paracetamol (acetaminophen) – a widely used analgesic and antipyretic.
• Form: Tablets (typically film-coated for ease of swallowing)
• Therapeutic Use: Short-term relief of:
  • Fever
  • Headache
  • Nasal congestion
  • Body aches and pains
  • Sore throat

The formulation may vary by region, but typically, PANADOL Cold & Flu combines:

• Paracetamol: For pain and fever
• Phenylephrine: A decongestant to relieve nasal blockage
• Sometimes an antihistamine like chlorpheniramine for sneezing or runny nose (in night variants)

This medicine is ideal for adults and children over 12 years experiencing cold or flu symptoms and looking for multi-symptom relief in a single dose.

How to use PANADOL Cold & Flu

Correct usage of PANADOL Cold & Flu is essential for effective symptom relief and to avoid potential side effects or overdose. Always follow the instructions on the packaging or as directed by a healthcare professional.

• Recommended Age: Suitable for adults and children over 12 years.
• Administration: Oral, with water. Can be taken with or without food.
• Dosing Frequency: Every 4 to 6 hours as required.

Important Usage Instructions:

• Do not exceed 4 doses (8 tablets) in 24 hours.
• Swallow tablets whole; do not crush or chew.
• If symptoms persist for more than 3 days, consult a healthcare provider.
• Do not use more than one paracetamol-containing product at the same time.

Day vs. Night Formulas:

• Daytime tablets typically contain a non-drowsy formulation (e.g., phenylephrine).
• Nighttime tablets may include a sedating antihistamine to aid rest and relieve runny nose or sneezing.

Missed a dose? Skip the missed dose if it’s close to the next. Never double up doses to make up for missed ones.

Mode of Action PANADOL Cold & Flu

PANADOL Cold & Flu acts through a combination of ingredients, each targeting a specific symptom of cold and flu. The synergistic effect helps provide comprehensive relief.

• Paracetamol (Acetaminophen):
  • Inhibits prostaglandin synthesis in the brain, which helps relieve pain and lower fever.
  • Acts centrally in the hypothalamus to reduce elevated body temperature.
• Phenylephrine (Decongestant):
  • Acts on alpha-adrenergic receptors in the nasal mucosa.
  • Causes vasoconstriction of dilated blood vessels, reducing nasal congestion and sinus pressure.
• Optional: Chlorpheniramine or Diphenhydramine (Antihistamine – in night formulas):
  • Blocks histamine receptors (H1), reducing symptoms like sneezing, itching, and runny nose.
  • Also induces mild sedation, helping with rest and sleep during illness.

This multi-modal action makes PANADOL Cold & Flu a go-to remedy for common cold and flu symptoms, especially when multiple symptoms are present simultaneously.

PANADOL Cold & Flu Interactions PANADOL Cold & Flu

PANADOL Cold & Flu contains multiple active ingredients, so it's important to be aware of potential drug interactions that could either amplify side effects or reduce efficacy.

• With other medications containing paracetamol:
  • Increases risk of liver toxicity; avoid using more than one paracetamol-containing medicine at a time.
• With monoamine oxidase inhibitors (MAOIs):
  • Combining with phenylephrine may lead to hypertensive crises.
  • Do not take within 14 days of stopping MAOIs.
• With beta-blockers or other antihypertensives:
  • Phenylephrine may reduce the effectiveness of these medications.
• With warfarin and other blood thinners:
  • Prolonged use of paracetamol may increase the risk of bleeding.
• Alcohol:
  • Should be avoided due to the risk of liver damage with paracetamol.

Always check with your doctor or pharmacist before combining this medicine with others, especially if you are taking prescription drugs for chronic conditions.

Dosage of PANADOL Cold & Flu

The dosage depends on age and health status, but in general, PANADOL Cold & Flu is intended for short-term use in adults and adolescents over 12 years.

• Adults and Children 12 years and older:
  • Take 1 to 2 tablets every 4–6 hours as needed.
  • Do not exceed 8 tablets in 24 hours.
• Children under 12:
  • Not recommended without specific pediatric formulation and medical advice.

Maximum duration of use:

• Do not use for more than 3 consecutive days without medical supervision.

Special considerations:

• In individuals with liver or kidney disease, consult a healthcare provider before use.
• Elderly patients may be more sensitive to side effects and should use under supervision.

Measure time between doses accurately and avoid combining with similar medications unless approved by a healthcare provider.

Possible side effects of PANADOL Cold & Flu

Most people tolerate PANADOL Cold & Flu well when taken as directed. However, like all medicines, it may cause side effects in some individuals.

• Common side effects:
  • Nausea or upset stomach
  • Restlessness or insomnia (especially with decongestants)
  • Mild drowsiness (more common with nighttime formulations)
• Less common but serious side effects:
  • Allergic reactions – rash, swelling of face/lips/tongue, or difficulty breathing
  • Liver toxicity – particularly with overdose or prolonged use
  • Increased heart rate or blood pressure (due to phenylephrine)
• Rare effects:
  • Blood disorders such as thrombocytopenia
  • Severe skin reactions (Stevens-Johnson syndrome – very rare)

If you or your child experience any serious side effects, stop using the medicine and seek medical help immediately.

PANADOL Cold & Flu Contraindications PANADOL Cold & Flu

PANADOL Cold & Flu should not be used in certain situations due to the risk of adverse effects or interactions.

• Absolute contraindications:
  • Known allergy to paracetamol, phenylephrine, or any other ingredient in the formulation.
  • Severe liver disease or active hepatic failure.
  • Use of monoamine oxidase inhibitors (MAOIs) within the last 14 days.
• Relative contraindications (consult a doctor):
  • Hypertension (high blood pressure)
  • Heart disease
  • Hyperthyroidism
  • Diabetes
  • Glaucoma
  • Prostate enlargement causing urinary retention

Pregnant or breastfeeding women should consult their doctor before using PANADOL Cold & Flu, as certain ingredients (like decongestants) may not be recommended.

Storage of PANADOL Cold & Flu

Storing PANADOL Cold & Flu properly is essential to maintain its effectiveness and prevent accidental ingestion by children.

• Storage Temperature: Store below 25°C (77°F). Keep in a cool, dry place away from moisture and heat.
• Packaging: Keep tablets in their original blister packaging until use to protect from light and contamination.
• Child Safety: Store out of reach and sight of children. Use childproof cabinets if available.

Other storage tips:

• Do not use after the expiry date printed on the carton and blister pack.
• If the tablets are discolored, chipped, or damaged, do not consume them.

Disposal: Return unused or expired medicine to your local pharmacy or a take-back program. Do not flush down the toilet or throw in household garbage.