PAMYLAR 2.5mg/ml Solution for injection

What is PAMYLAR 2.5mg/ml

PAMYLAR 2.5mg/ml is a medication used to treat various cardiovascular conditions, including supraventricular tachycardia, atrial fibrillation, and hypertension. It contains Verapamil Hydrochloride, a calcium channel blocker that works by relaxing blood vessels and reducing heart rate.

How to use PAMYLAR 2.5mg/ml

PAMYLAR 2.5mg/ml is administered via injection, typically intravenously. The solution is usually given under the supervision of a healthcare provider in a medical setting.

• Administration: The injection is typically given by a healthcare professional in a hospital or clinic setting.
• Dosing Schedule: The dosing schedule may vary depending on the specific treatment and patient needs.

It's essential to follow the specific instructions provided by your healthcare provider for administering PAMYLAR.

Mode of Action PAMYLAR 2.5mg/ml

Verapamil Hydrochloride in PAMYLAR 2.5mg/ml works by selectively blocking L-type calcium channels in the heart and blood vessels. This leads to:

• Vasodilation: PAMYLAR relaxes blood vessels, reducing blood pressure and improving blood flow.
• Negative Chronotropy: Verapamil reduces heart rate, decreasing the workload on the heart.
• Negative Inotropy: PAMYLAR decreases the contractility of the heart, further reducing the workload on the heart.

This mechanism of action is crucial for managing various cardiovascular conditions.

PAMYLAR 2.5mg/ml Interactions PAMYLAR 2.5mg/ml

PAMYLAR 2.5mg/ml can interact with other medications or worsen certain medical conditions. Some potential interactions include:

• Beta Blockers: Concomitant use with beta blockers may increase the risk of bradycardia and hypotension.
• Digoxin: PAMYLAR may increase digoxin levels, increasing the risk of toxicity.
• Other Antihypertensive Agents: Concomitant use with other antihypertensive agents may increase the risk of hypotension.

Always inform your healthcare provider about all the medications you are taking to avoid potential interactions.

Dosage of PAMYLAR 2.5mg/ml

The recommended dosage of PAMYLAR 2.5mg/ml is typically:

• 5-10mg administered intravenously, repeated as necessary, under the supervision of a healthcare provider.

The exact dosage and timing may vary based on individual patient needs and response to treatment, as determined by a healthcare provider.

Possible side effects of PAMYLAR 2.5mg/ml

While generally well-tolerated, PAMYLAR 2.5mg/ml can cause some side effects, including:

• Bradycardia: Slow heart rate can occur.
• Hypotension: Low blood pressure can occur.
• Dizziness: Dizziness or lightheadedness can occur.
• Headache: Mild to moderate headaches can occur.

If any side effects persist or worsen, consult your healthcare provider for guidance.

PAMYLAR 2.5mg/ml Contraindications PAMYLAR 2.5mg/ml

Important Contraindications to Consider

• Hypersensitivity: Individuals known to be hypersensitive to Verapamil Hydrochloride or any other ingredient in the formulation should not use PAMYLAR.
• Severe Left Ventricular Dysfunction: Patients with severe left ventricular dysfunction should not use PAMYLAR.
• Heart Block: Patients with heart block should not use PAMYLAR.
• Sick Sinus Syndrome: Patients with sick sinus syndrome should not use PAMYLAR, unless a pacemaker is in place.
• Severe Bradycardia: Patients with severe bradycardia should not use PAMYLAR.

Precautions

Before administering PAMYLAR 2.5mg/ml, healthcare providers should carefully evaluate patients with certain medical conditions, such as:

• Heart Failure: Patients with heart failure should be closely monitored.
• Hypotension: Patients with hypotension should be closely monitored.
• Liver or Kidney Impairment: Patients with liver or kidney impairment may require dose adjustments.

Importance of Medical History

It's essential to provide a complete medical history to your healthcare provider before starting treatment with PAMYLAR 2.5mg/ml.

Storage of PAMYLAR 2.5mg/ml

Proper Storage Guidelines

Proper storage of PAMYLAR 2.5mg/ml is essential to maintain its efficacy and safety. Here are the storage guidelines:

• Room Temperature: Store the vials at room temperature, between 15°C to 30°C (59°F to 86°F).
• Protect from Light: Keep the vials in the original packaging to protect them from light.
• Do not Freeze: The solution should not be frozen.
• Expiry: Do not use PAMYLAR after the expiry date printed on the packaging.

Importance of Proper Storage

By following these storage guidelines, you can ensure the quality and effectiveness of PAMYLAR 2.5mg/ml.