PABRINEX IM Injection

What is PABRINEX IM

PABRINEX IM is an injectable solution that combines a blend of essential vitamins, namely Vitamin B1 (Thiamine), Vitamin B2 (Riboflavin), Vitamin B6 (Pyridoxine), Niacinamide, and Vitamin C (Ascorbic Acid). This combination is formulated to provide therapeutic support for patients with vitamin deficiencies, especially those who are unable to receive adequate nutrition through oral supplementation alone.

This medication is typically administered intramuscularly (IM) or intravenously (IV) under medical supervision, making it a highly effective means of rapidly delivering vitamins directly into the bloodstream. PABRINEX IM is commonly used in cases of severe malnutrition, alcohol dependence, or specific conditions that lead to vitamin depletion, such as certain chronic illnesses.

Key Components and Their Functions:

• Vitamin B1 (Thiamine): Essential for the metabolism of carbohydrates and maintaining nervous system function.
• Vitamin B2 (Riboflavin): Plays a role in energy production and supports the function of enzymes involved in cellular metabolism.
• Vitamin B6 (Pyridoxine): Involved in amino acid metabolism, neurotransmitter synthesis, and immune function.
• Niacinamide (Vitamin B3): Important for the conversion of carbohydrates, fats, and proteins into energy, and for maintaining skin and digestive system health.
• Vitamin C (Ascorbic Acid): Powerful antioxidant that supports immune health, wound healing, and the synthesis of collagen and neurotransmitters.

PABRINEX IM provides a synergistic effect by delivering a combination of these nutrients to address multiple deficiencies at once, making it especially useful for patients in critical care or undergoing intensive rehabilitation.

How to use PABRINEX IM

PABRINEX IM should only be used as directed by a healthcare professional, typically in a hospital or clinical setting. It is administered by injection, either intramuscularly (IM) or intravenously (IV), depending on the patient's condition and the healthcare provider’s recommendations.

Dosage and Administration:

• Injection Volume: The usual dosage is one 5 mL ampoule (containing the full dose of vitamins) for intramuscular or intravenous administration.
• Frequency of Use: The frequency may vary based on the clinical condition, but often, it is administered daily or several times a week in cases of severe vitamin deficiencies.
• Route of Administration: PABRINEX IM is generally administered intramuscularly (IM) but may also be given intravenously (IV) under medical supervision, especially in emergency situations.

Preparation and Administration:

• Visual Inspection: Ensure that the solution is clear and free of any particulate matter before administration. Do not use if the solution is discolored or contains particles.
• Injection Site: For IM administration, the injection should be given in a large muscle, usually in the upper arm, thigh, or buttock. Rotate sites if multiple doses are required to avoid irritation.
• IV Administration: If given intravenously, it must be done slowly under controlled conditions to avoid complications.

Warning: PABRINEX IM is for professional use only. Always follow the prescribed dosage, and do not attempt self-administration outside of a healthcare facility.

Mode of Action PABRINEX IM

The vitamins present in PABRINEX IM each play a crucial role in various biochemical pathways within the body. By directly introducing these vitamins into the bloodstream, PABRINEX IM provides an immediate and effective means of restoring vitamin levels and supporting numerous vital physiological functions.

Thiamine (Vitamin B1): Thiamine is primarily involved in energy metabolism. It acts as a coenzyme in carbohydrate metabolism, assisting in the conversion of glucose into energy. It is essential for the normal functioning of the nervous system, and a deficiency can lead to symptoms such as confusion, neuropathy, and in severe cases, Wernicke-Korsakoff syndrome.

Riboflavin (Vitamin B2): Riboflavin is necessary for the metabolism of fats, proteins, and carbohydrates. It is involved in the redox reactions in the electron transport chain, facilitating ATP production and overall energy metabolism. Riboflavin deficiency can cause sore throat, skin disorders, and cataracts.

Pyridoxine (Vitamin B6): Vitamin B6 is crucial for amino acid metabolism, neurotransmitter synthesis (e.g., serotonin, dopamine), and red blood cell production. It also plays a role in maintaining immune function. A deficiency can lead to symptoms such as irritability, depression, and confusion.

Niacinamide (Vitamin B3): Niacinamide is essential for the production of NAD (Nicotinamide adenine dinucleotide), which is involved in cellular metabolism. Niacinamide also supports skin health and digestive function. Deficiency of this vitamin can lead to conditions like pellagra, which is characterized by dermatitis, diarrhea, and dementia.

Ascorbic Acid (Vitamin C): Vitamin C is a potent antioxidant that supports immune health and promotes collagen formation. It also facilitates the absorption of iron from the gastrointestinal tract. Deficiency can lead to scurvy, with symptoms such as fatigue, swollen gums, and joint pain.

Overall, the combined effects of these vitamins work synergistically to improve metabolism, support the immune system, and enhance cellular repair mechanisms, particularly during periods of nutritional stress or deficiency.

PABRINEX IM Interactions PABRINEX IM

PABRINEX IM (containing multiple B vitamins and Vitamin C) is generally well-tolerated, but there are several drug interactions to consider when it is used alongside other medications. Some medications can either enhance or diminish the effects of these vitamins.

Drug Interactions:

• Antibiotics: Certain antibiotics, such as tetracyclines, may interact with Vitamin C, potentially decreasing its effectiveness.
• Anticoagulants (e.g., Warfarin): High doses of Vitamin C may interfere with the effectiveness of anticoagulants, increasing the risk of clotting or bleeding.
• Alcohol: Chronic alcohol consumption can impair the absorption of B vitamins, particularly thiamine and folate, and may exacerbate deficiency symptoms when combined with PABRINEX IM.
• Diuretics: Some diuretics, such as furosemide, may cause the body to excrete more Vitamin B1 (thiamine), leading to deficiencies. Vitamin supplementation can help offset this loss.
• Other Vitamin Supplements: When using other vitamin supplements concurrently, care must be taken not to exceed recommended dosages, particularly of Vitamin B6 and Vitamin C, as excessive intake can lead to toxicity.

Recommendation: Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs, herbal supplements, and alcohol use, to avoid adverse interactions and ensure the safety and effectiveness of PABRINEX IM.

Dosage of PABRINEX IM

The dosage of PABRINEX IM varies based on the patient’s condition and the severity of their vitamin deficiencies. It is essential that this medication be administered under the guidance of a healthcare professional to ensure the correct dosage and administration route.

Typical Dosage Guidelines:

• General Vitamin Deficiency: One 5mL ampoule is typically administered once a day via intramuscular (IM) or intravenous (IV) injection.
• Alcohol-Related Deficiency: In patients with chronic alcoholism, two or more daily injections may be needed to correct vitamin deficiencies, especially thiamine and B6.
• Malnutrition and Severe Deficiencies: In severe cases, the dosage may be increased temporarily under close medical supervision, based on the patient's response to therapy.
• Maintenance Dose: Once the acute deficiency is corrected, the dosage may be reduced to one injection per week or as directed by the healthcare provider.

Dosage adjustments are necessary for patients with impaired liver function, renal disorders, or those undergoing long-term treatments. Overuse of PABRINEX IM can lead to vitamin toxicity, particularly Vitamin B6 or Vitamin C, so adherence to prescribed doses is critical.

Possible side effects of PABRINEX IM

Common Side Effects:

• Pain, swelling, or redness at the injection site
• Headache
• Fever or chills
• Rash or skin irritation
• Dizziness or lightheadedness

Serious Side Effects:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Severe irritation or abscess at the injection site
• Hypervitaminosis, especially with prolonged use (Vitamin B6 toxicity, causing neurological symptoms)
• Gastrointestinal upset (nausea, vomiting, abdominal cramps)

If you experience any serious side effects or signs of an allergic reaction, seek medical attention immediately. Always report any unusual symptoms to your healthcare provider for evaluation.

PABRINEX IM Contraindications PABRINEX IM

PABRINEX IM should be used with caution in certain populations, and it is contraindicated in specific conditions due to the risk of adverse reactions.

Absolute Contraindications:

• Known hypersensitivity or allergy to any of the components (Vitamin B1, B2, B6, Niacinamide, Vitamin C)
• Severe renal or hepatic failure
• Patients with a history of allergy to parenteral (injectable) vitamin preparations

Relative Contraindications:

• Pregnancy and breastfeeding (use only if clearly necessary and under medical supervision)
• Patients with existing kidney disorders, especially those on dialysis
• Individuals with a history of high doses of Vitamin B6 intake (avoid in excessive doses to prevent toxicity)

Before administering PABRINEX IM, patients should be carefully evaluated for any contraindications to ensure safety.

Storage of PABRINEX IM

Proper storage of PABRINEX IM is essential to maintain the stability and efficacy of the medication.

Storage Guidelines:

• Temperature: Store at room temperature, away from direct sunlight and excessive heat, ideally between 15°C to 30°C (59°F to 86°F).
• Avoid Freezing: Do not freeze the injection solution as it may cause the solution to degrade.
• Protect from Light: Keep the ampoules in their original packaging to protect them from light exposure.
• Keep Out of Reach of Children: Ensure the product is stored in a safe place, out of reach of children and pets.

Do not use the solution if it has expired or appears damaged. Dispose of any unused or expired medication according to local regulations.