PABENDROL 10mcg Tablets

What is PABENDROL 10mcg

What is PABENDROL 10mcg?

PABENDROL 10mcg is an oral tablet formulation that contains 10 micrograms of Ethinyloestradiol, a synthetic derivative of the naturally occurring hormone estrogen. It is most commonly used in combination with a progestin in oral contraceptives, but it also serves roles in hormone replacement therapy (HRT), management of menstrual disorders, and treatment of certain hormone-responsive cancers.

Ethinyloestradiol mimics the biological activity of endogenous estrogens, binding to estrogen receptors throughout the body. These receptors are predominantly located in reproductive tissues, bones, liver, and the cardiovascular system.

PABENDROL is generally prescribed to:

• Prevent pregnancy (in combination with a progestogen)
• Regulate menstrual cycles and treat amenorrhea
• Manage menopausal symptoms like hot flashes and vaginal dryness
• Prevent osteoporosis in postmenopausal women

Due to its potency, low doses such as 10 mcg are sufficient for therapeutic action. However, usage must be carefully monitored due to the potential for systemic side effects and hormone-related risks.

How to use PABENDROL 10mcg

How to Use PABENDROL 10mcg

PABENDROL 10mcg tablets are intended for oral administration. The exact dosing schedule will depend on the indication (e.g., contraception, HRT, or treatment of estrogen deficiency), and it should always be guided by a physician.

• Administration: Swallow the tablet whole with water. It can be taken with or without food.
• Timing: For contraceptive use, take one tablet at the same time every day for maximum efficacy.
• Consistency: Daily use without interruption is crucial for hormonal balance and treatment effectiveness.
• Missed Dose: If a dose is missed, it should be taken as soon as remembered. If it’s nearly time for the next dose, skip the missed one. Do not double the dose.

In contraceptive regimens, Ethinyloestradiol is typically taken for 21 days followed by a 7-day tablet-free period (or placebo tablets). For HRT, cyclical or continuous regimens may be used, often in combination with a progestin to reduce the risk of endometrial hyperplasia.

It is important to follow your healthcare provider’s directions precisely to avoid hormonal imbalances, unwanted pregnancy, or adverse effects.

Mode of Action PABENDROL 10mcg

Mode of Action of PABENDROL 10mcg

Ethinyloestradiol, the active ingredient in PABENDROL 10mcg, is a synthetic estrogen that mimics the function of natural estrogens in the body. It acts by binding to intracellular estrogen receptors, forming a hormone-receptor complex that translocates to the nucleus and modulates gene expression.

This leads to the production of proteins that are responsible for the development and regulation of the female reproductive system and secondary sexual characteristics. In contraceptive use, Ethinyloestradiol:

• Inhibits ovulation by suppressing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH)
• Alters cervical mucus, making it more difficult for sperm to penetrate
• Modifies the endometrial lining, making implantation less likely

Beyond contraception, Ethinyloestradiol supports estrogen-deficient states in menopausal women and helps in the management of conditions like polycystic ovary syndrome (PCOS), amenorrhea, and acne.

The pharmacological action is systemic and multifactorial, involving hepatic protein synthesis, changes in lipid metabolism, and modulation of the hypothalamic-pituitary-ovarian axis.

PABENDROL 10mcg Interactions PABENDROL 10mcg

Interactions of PABENDROL 10mcg

PABENDROL 10mcg (Ethinyloestradiol) may interact with a variety of medications, potentially reducing its effectiveness or increasing the risk of side effects. Drug interactions can occur at the metabolic level (hepatic enzyme induction/inhibition) or affect pharmacodynamics.

Drugs that may reduce effectiveness:

• Rifampicin, Rifabutin: Induce CYP450 enzymes, increasing estrogen metabolism
• Phenytoin, Carbamazepine, Phenobarbital: Anticonvulsants that accelerate estrogen breakdown
• St. John's Wort: Herbal remedy that decreases plasma concentrations of Ethinyloestradiol

Drugs that may increase estrogen levels or side effects:

• Antibiotics (e.g. erythromycin): May interfere with enterohepatic recycling of estrogens
• Protease inhibitors: Some used in HIV treatment can either increase or decrease estrogen levels
• Grapefruit juice: Can inhibit CYP3A4 and raise estrogen levels

Always inform your healthcare provider about all medications, including supplements and herbal products, before starting PABENDROL to ensure safe use.

Dosage of PABENDROL 10mcg

Dosage of PABENDROL 10mcg

The dosage of PABENDROL 10mcg varies based on the condition being treated. It is essential that dosing be individualized and monitored by a healthcare professional.

• Contraception (Combined Oral Contraceptive): Usually, one tablet containing Ethinyloestradiol and a progestin is taken daily for 21 days followed by a 7-day break or placebo tablets.
• Hormone Replacement Therapy: Postmenopausal women may take Ethinyloestradiol continuously or cyclically, often alongside a progestogen. Dosing is typically lower than contraceptive doses.
• Estrogen Deficiency or Menstrual Irregularities: Dosages may range from 10–50 mcg daily, depending on response and tolerance.

Patients with liver dysfunction, history of thromboembolic events, or those on enzyme-inducing drugs may require dosage adjustments or monitoring.

Never self-medicate or adjust your dose without medical advice.

Possible side effects of PABENDROL 10mcg

Possible Side Effects of PABENDROL 10mcg

Like all medications, PABENDROL 10mcg can cause side effects. Most are mild and transient, but some may be serious and require medical attention.

Common Side Effects:

• Nausea or vomiting
• Breast tenderness or enlargement
• Headaches
• Spotting or irregular menstrual bleeding
• Mood changes or irritability

Less Common but Serious Side Effects:

• Increased risk of venous thromboembolism (blood clots)
• Hypertension (elevated blood pressure)
• Visual disturbances or ocular pain
• Signs of liver dysfunction (jaundice, dark urine)

Allergic reactions are rare but may include rash, swelling, or breathing difficulties. Seek immediate medical help if these occur.

Report any new or worsening symptoms to your doctor immediately, especially if you're a smoker over 35, or have a history of cardiovascular issues.

PABENDROL 10mcg Contraindications PABENDROL 10mcg

Contraindications of PABENDROL 10mcg

PABENDROL 10mcg should not be used in patients who have certain medical conditions where estrogen therapy may worsen the disease or present significant risk.

Absolute Contraindications:

• Pregnancy
• Breast cancer or estrogen-dependent tumors
• History of thromboembolic events (DVT, PE)
• Severe liver disease or liver tumors
• Undiagnosed vaginal bleeding

Relative Contraindications (use with caution):

• Smokers over 35 years old
• Hypertension or cardiovascular disease
• Diabetes with complications
• History of migraine headaches

Always consult with a healthcare provider before starting treatment to assess suitability based on your medical history and risks.

Storage of PABENDROL 10mcg

Storage of PABENDROL 10mcg

PABENDROL 10mcg should be stored properly to maintain its efficacy and safety. Follow these guidelines:

• Temperature: Store the tablets at room temperature, typically between 20°C to 25°C (68°F to 77°F).
• Humidity: Keep the tablets in a dry place, away from excessive moisture.
• Protect from Light: Store in the original packaging or container to shield from light.
• Disposal: Dispose of expired or unused tablets according to local regulations. Do not flush down the toilet or pour down the drain.

Keep the medication out of reach of children and pets. If you have any questions about storage or disposal, consult your pharmacist.