PABAVIT VITAMIN A 50,000 IU Capsules

What is PABAVIT VITAMIN A 50,000 IU

PABAVIT VITAMIN A 50,000 IU is a pharmaceutical preparation containing Vitamin K, specifically in the form of Vitamin K1 (phytonadione). It is available in capsule form, with each capsule delivering 50,000 International Units (IU) of Vitamin K. This product is manufactured by Paines & Byrne Limited and is distributed by New Medical Centre in the UAE. It is typically supplied in a 1000-capsule bottle, indicating its use for long-term supplementation or for clinical settings requiring bulk supplies.

• Generic Name: Vitamin K1 (phytonadione)
• Strength: 50,000 IU per capsule
• Formulation: Oral capsule
• Pack Size: 1000 capsules per bottle
• Manufacturer: Paines & Byrne Limited
• Distributor: New Medical Centre, UAE

Vitamin K1 is essential for the synthesis of clotting factors in the liver and plays a crucial role in bone metabolism and vascular health. PABAVIT VITAMIN A 50,000 IU is indicated for the prevention and treatment of Vitamin K deficiency, which can lead to bleeding disorders due to impaired blood clotting.

How to use PABAVIT VITAMIN A 50,000 IU

The administration of PABAVIT VITAMIN A 50,000 IU should be done under medical supervision, especially considering the high dosage per capsule. The general guidelines for its use are as follows:

• Dosage: The typical adult dose ranges from 2.5 to 25 milligrams (mg), with rare cases requiring up to 50 mg, depending on the severity of Vitamin K deficiency and the patient's response to treatment.
• Administration: The capsule should be swallowed whole with a full glass of water. It should not be opened or chewed.
• Timing: The dosing schedule should be determined by a healthcare provider, based on the individual's specific needs and medical condition.
• Monitoring: Regular monitoring of prothrombin time (PT) and International Normalized Ratio (INR) is recommended to assess the effectiveness of treatment and adjust the dosage accordingly.

It is important to follow the prescribed regimen and not to self-adjust the dosage without consulting a healthcare professional, as improper use can lead to complications.

Mode of Action PABAVIT VITAMIN A 50,000 IU

Vitamin K1 (phytonadione), the active ingredient in PABAVIT VITAMIN A 50,000 IU, exerts its effects through the following mechanisms:

• Clotting Factor Synthesis: Vitamin K1 is essential for the synthesis of clotting factors II (prothrombin), VII, IX, and X in the liver. These factors are crucial for the blood coagulation cascade, which prevents excessive bleeding.
• Bone Health: Vitamin K1 contributes to bone mineralization by activating osteocalcin, a protein involved in bone formation.
• Vascular Health: It also plays a role in regulating vascular calcification, thereby supporting cardiovascular health.

By restoring adequate levels of Vitamin K1, PABAVIT VITAMIN A 50,000 IU helps in the prevention and treatment of bleeding disorders associated with Vitamin K deficiency.

PABAVIT VITAMIN A 50,000 IU Interactions PABAVIT VITAMIN A 50,000 IU

Vitamin K1 can interact with various medications and substances, potentially affecting its efficacy or leading to adverse effects:

• Anticoagulants: Concurrent use with anticoagulants like warfarin can reduce their effectiveness, as Vitamin K promotes clotting. Monitoring of INR is essential.
• Antibiotics: Broad-spectrum antibiotics may decrease the intestinal flora responsible for synthesizing Vitamin K, leading to deficiency.
• Cholestyramine and Orlistat: These drugs can impair the absorption of fat-soluble vitamins, including Vitamin K.
• Alcohol: Excessive alcohol consumption can interfere with Vitamin K metabolism in the liver.

Patients should inform their healthcare providers of all medications and supplements they are taking to manage potential interactions effectively.

Dosage of PABAVIT VITAMIN A 50,000 IU

The appropriate dosage of PABAVIT VITAMIN A 50,000 IU varies based on individual needs and medical conditions:

• Adults: The usual dose ranges from 2.5 to 25 mg, with rare cases requiring up to 50 mg, depending on the severity of Vitamin K deficiency.
• Children: Use is not recommended due to the high dosage per capsule. Pediatric dosing should be determined by a healthcare provider.
• Renal Impairment: Caution is advised, and dosage adjustments may be necessary in patients with kidney disease.
• Liver Disease: Patients with liver dysfunction may require careful monitoring and possible dosage modifications.

It is crucial to adhere to the prescribed dosage and schedule to avoid complications associated with both deficiency and excess Vitamin K.

Possible side effects of PABAVIT VITAMIN A 50,000 IU

While Vitamin K1 is generally well-tolerated, some individuals may experience side effects:

• Common: Nausea, loss of appetite, or stomach upset.
• Less Common: Rash, fever, or dizziness.
• Serious: Allergic reactions such as difficulty breathing, swelling of the face or throat, or severe dizziness.

Patients should seek immediate medical attention if they experience any signs of a serious allergic reaction or other unusual symptoms.

PABAVIT VITAMIN A 50,000 IU Contraindications PABAVIT VITAMIN A 50,000 IU

Contraindications of PABAVIT VITAMIN A 50,000 IU

This supplement is contraindicated in individuals with known hypersensitivity to vitamin A or any component of the capsule formulation.

It should not be used in patients with hypervitaminosis A or chronic liver disease unless under strict medical supervision due to the risk of exacerbating hepatic impairment.

High-dose vitamin A is contraindicated in pregnancy due to the risk of teratogenic effects. Women of childbearing age should use contraception while taking high-dose vitamin A and consult their physician if planning pregnancy.

Patients receiving other retinoid medications or those with compromised renal or hepatic function should be assessed carefully before initiating treatment with PABAVIT.

Storage of PABAVIT VITAMIN A 50,000 IU

Storage of PABAVIT VITAMIN A 50,000 IU

Store the capsules in a cool, dry place away from direct sunlight and moisture, ideally below 25°C (77°F). Avoid exposure to excessive heat or freezing temperatures.

Keep the container tightly closed and out of reach of children. Do not use the product after the expiry date indicated on the bottle.

Proper storage helps preserve the potency and effectiveness of the capsules. Always store in original packaging and avoid transferring contents to unlabelled containers.

In case of any discoloration or change in capsule appearance, consult a pharmacist before use.