OXADILENE Tablets

What is OXADILENE

OXADILENE is a medicinal product containing Papaverine Hydrochloride, a vasodilator used primarily to manage various types of smooth muscle spasms and circulatory disorders. Presented in tablet form, each dose aims to reduce involuntary muscle contractions and improve blood flow to targeted regions.

• Therapeutic class: Antispasmodic and vasodilator
• Generic name: Papaverine HCl
• Form: Oral tablets
• Common uses: Treatment of visceral spasm (in gastrointestinal or biliary tract), peripheral vascular disease, cerebral vasospasm, and erectile dysfunction in some cases

Papaverine acts directly on smooth muscle tissues and is non-narcotic, despite being derived from opium alkaloids.

How to use OXADILENE

OXADILENE tablets should be taken as prescribed by a healthcare professional. Improper usage may reduce efficacy or increase the risk of side effects.

• Administration route: Oral
• Timing: Usually taken 3 to 4 times a day, with or without food
• Swallow whole: Do not crush or chew the tablet unless instructed
• Hydration: Take with a full glass of water

Important Tips:

• Stick to the dosage schedule; do not double up on missed doses
• Avoid alcohol or other CNS depressants unless cleared by your doctor
• Do not discontinue suddenly without medical advice

Mode of Action OXADILENE

Papaverine exerts its effects by relaxing smooth muscle through inhibition of phosphodiesterase enzymes, which leads to increased levels of cyclic AMP and GMP.

• Primary effect: Smooth muscle relaxation in blood vessels and viscera
• Mechanism: Non-specific inhibition of phosphodiesterase enzymes
• Outcome: Vasodilation and improved blood circulation

This action helps in alleviating pain or dysfunction associated with spasms and enhances tissue oxygenation in ischemic conditions.

OXADILENE Interactions OXADILENE

OXADILENE can interact with several medications, altering its effects or increasing the risk of adverse reactions.

• Antihypertensives: Enhanced hypotensive effects
• Other vasodilators: Potentiation of vasodilatory actions
• MAO inhibitors: Increased risk of cardiovascular effects
• Alcohol: May enhance CNS side effects like dizziness or sedation

Always provide a full list of current medications to your doctor to prevent harmful interactions.

Dosage of OXADILENE

The dosage of OXADILENE varies depending on the patient’s condition, age, and medical history.

• Adults: 150 to 300 mg orally, 3 to 4 times per day (divided doses)
• Maximum daily dose: Should not exceed 600 mg unless specified by a physician
• Children: Not commonly recommended unless specifically advised

Dosage adjustments may be necessary for those with liver dysfunction or elderly patients due to altered metabolism.

Possible side effects of OXADILENE

OXADILENE is generally well tolerated, but some individuals may experience side effects. These can range from mild to severe.

• Common side effects:
  • Flushing
  • Headache
  • Dizziness
  • Nausea or gastrointestinal upset
• Less common but serious side effects:
  • Hypotension (low blood pressure)
  • Irregular heartbeat
  • Liver enzyme elevation

Seek immediate medical attention if you experience chest pain, yellowing of the skin (jaundice), or fainting.

OXADILENE Contraindications OXADILENE

Certain medical conditions and scenarios make the use of OXADILENE unsuitable.

• Hypersensitivity: Known allergy to papaverine or any of the tablet components
• Complete atrioventricular (AV) block: May worsen conduction issues
• Severe liver dysfunction: Risk of drug accumulation and toxicity
• Pediatric use: Safety in children has not been established

Always consult your physician before initiating treatment if you have cardiovascular disease or are taking medications that affect heart rhythm or blood pressure.

Storage of OXADILENE

Proper storage of OXADILENE ensures its effectiveness and prevents deterioration.

• Temperature: Store at room temperature (15°C to 25°C)
• Keep away from moisture and light: Store in a dry place in the original packaging
• Keep out of reach of children
• Do not use after the expiration date printed on the package

Do not flush unused medication down the toilet; follow local guidelines for disposal.