OVITRELLE 250mcg Injection/Solution for

What is OVITRELLE 250mcg

OVITRELLE 250mcg is a prescription fertility medication containing the active substance choriogonadotropin alfa, a recombinant form of human chorionic gonadotropin (hCG). It is biologically engineered using recombinant DNA technology, ensuring high purity and consistent results.

OVITRELLE is supplied in a ready-to-use 0.5ml pre-filled syringe for subcutaneous injection, eliminating the need for reconstitution or mixing. This form is convenient, sterile, and designed for single-use only.

It is primarily used in women undergoing fertility treatment to trigger final maturation of eggs and induce ovulation following stimulation of follicular development. It is especially useful in assisted reproductive techniques (ART) such as:

• In vitro fertilization (IVF)
• Intrauterine insemination (IUI)
• Timed intercourse cycles

By mimicking the natural luteinizing hormone (LH) surge, OVITRELLE facilitates the release of mature eggs from the ovaries at the optimal time, improving the chances of conception. It is prescribed and administered under the close guidance of a fertility specialist.

How to use OVITRELLE 250mcg

OVITRELLE 250mcg should always be used exactly as prescribed by your healthcare provider. It is intended for subcutaneous (under the skin) injection and is administered in a single dose, typically timed precisely according to your fertility treatment plan.

• Preparation:
  • Wash your hands thoroughly before handling the syringe.
  • Remove the pre-filled syringe from the refrigerator and allow it to reach room temperature naturally.
  • Inspect the solution. It should be clear and colorless. Do not use if cloudy or if particles are present.
• Injection technique:
  • Choose a clean, dry injection site (usually the thigh or lower abdomen).
  • Disinfect the area with an alcohol swab.
  • Remove the needle cap, pinch the skin, and insert the needle at a 45° or 90° angle as instructed by your healthcare provider.
  • Inject the full 0.5ml solution slowly and steadily.
  • Dispose of the syringe in a proper sharps container.
• Post-injection:
  • Do not massage the injection site.
  • Record the date and time of injection for reference in your fertility schedule.

Do not attempt to inject yourself unless you have been thoroughly instructed by a healthcare professional. If you miss a dose or inject at the wrong time, contact your doctor immediately.

Mode of Action OVITRELLE 250mcg

OVITRELLE 250mcg functions by mimicking the natural activity of luteinizing hormone (LH), a key hormone in the reproductive process. The active ingredient, choriogonadotropin alfa, is a recombinant form of hCG that binds to LH/hCG receptors in the ovary to complete the maturation of developing follicles and stimulate ovulation.

This action triggers the following physiological processes:

• Follicular maturation: The injection promotes the final maturation of the ovarian follicle, allowing the egg to become capable of fertilization.
• Ovulation induction: Within 36–40 hours of injection, the matured egg is released from the ovary, enabling fertilization to occur if intercourse or insemination is timed correctly.
• Corpus luteum support: Post-ovulation, the corpus luteum forms and begins producing progesterone, which supports implantation and early pregnancy.

As a recombinant product, OVITRELLE offers a purer and more consistent alternative to urinary-derived hCG. It ensures precise dosing and reproducible results in fertility management.

OVITRELLE 250mcg Interactions OVITRELLE 250mcg

OVITRELLE has a relatively limited profile of drug interactions, but it is crucial to inform your doctor of all medications, supplements, and herbal products you are using, especially when undergoing fertility treatment. Important interactions and considerations include:

• Fertility medications:
  • Often used in combination with FSH (follicle-stimulating hormone) or hMG (human menopausal gonadotropin) to stimulate follicular growth.
  • Combined use requires careful monitoring to prevent ovarian hyperstimulation syndrome (OHSS).
• Hormonal contraceptives:
  • Should be discontinued before starting OVITRELLE, as they may counteract its ovulation-inducing effects.
• Glucocorticoids and thyroid medications:
  • Patients on long-term hormonal treatments should be closely monitored.
• Interactions with laboratory tests:
  • May cause false-positive pregnancy tests due to its hCG activity for up to 10 days post-injection.

Your fertility specialist will take all necessary precautions to avoid adverse interactions during your treatment plan.

Dosage of OVITRELLE 250mcg

The recommended dosage of OVITRELLE for most fertility protocols is:

• One pre-filled syringe (0.5ml) containing 250 micrograms of choriogonadotropin alfa.
• Route: Subcutaneous injection (under the skin), typically administered in the abdomen or thigh.
• Timing: Injection is scheduled approximately 24 to 36 hours before ovulation or egg retrieval, depending on the specific fertility protocol (e.g., IUI or IVF).

This single dose mimics the natural LH surge required to trigger ovulation. Your doctor will time the injection precisely based on ultrasound monitoring and blood hormone levels.

Special considerations:

• Only one injection per cycle is usually required.
• Do not take more than the prescribed amount.
• If the timing of the dose is off, contact your doctor immediately as it may affect your treatment success.

Never share your pre-filled syringe with anyone else, and always follow your healthcare provider’s instructions carefully.

Possible side effects of OVITRELLE 250mcg

Like all medications, OVITRELLE may cause side effects, although not everyone experiences them. Side effects may be mild, moderate, or, rarely, severe. The most commonly reported reactions are related to hormone fluctuations and injection site discomfort.

• Very common to common:
  • Abdominal pain or discomfort
  • Injection site redness, swelling, or bruising
  • Fatigue or drowsiness
  • Headache
  • Nausea or bloating
• Less common:
  • Breast tenderness
  • Skin rash or mild allergic reaction
• Serious but rare:
  • Ovarian Hyperstimulation Syndrome (OHSS): Characterized by severe bloating, sudden weight gain, vomiting, and reduced urination. Requires urgent medical attention.
  • Allergic reactions: Swelling of the face, lips, tongue, or throat; difficulty breathing; or severe rash (anaphylaxis).
  • Thromboembolic events: Rare blood clot formation in veins or arteries.

If you experience any side effects that are persistent, worsening, or concerning, contact your healthcare provider immediately.

OVITRELLE 250mcg Contraindications OVITRELLE 250mcg

OVITRELLE 250mcg should not be used in certain medical conditions. Patients with the following contraindications must avoid its use:

• Known allergy or hypersensitivity to choriogonadotropin alfa or any excipients in the formulation
• Hormone-sensitive cancers (e.g., ovarian, uterine, or breast cancer)
• Unexplained vaginal or uterine bleeding
• Primary ovarian failure (where ovulation induction would be ineffective)
• Enlarged ovaries or ovarian cysts not related to polycystic ovary syndrome (PCOS)
• Severe liver, heart, or kidney disease
• Pregnancy or suspected pregnancy

Before starting OVITRELLE, your doctor will conduct a comprehensive evaluation, including medical history, physical examination, and hormonal tests, to ensure it is safe and appropriate for you.

Storage of OVITRELLE 250mcg

Proper storage of OVITRELLE is critical to maintaining its efficacy and safety. Follow these guidelines carefully:

• Refrigeration: Store at 2°C to 8°C (36°F to 46°F). Keep the pre-filled syringe in the original packaging to protect it from light.
• Room temperature: If necessary, the syringe may be stored at temperatures up to 25°C (77°F) for a single period of up to 30 days. Do not return it to the refrigerator once removed.
• Do not freeze: Freezing can destroy the active protein. Discard if accidentally frozen.
• Disposal: Do not use after the expiration date printed on the package. Dispose of used or expired syringes in a proper sharps container.