OTRIVIN 0.05% (Children) Nasal Spray

What is OTRIVIN 0.05% (Children)

OTRIVIN 0.05% (Children) is a nasal spray specifically formulated for children, containing the active ingredient Xylometazoline Hydrochloride at a concentration of 0.05%. It is classified as a topical nasal decongestant and is commonly used to relieve nasal congestion associated with:

• Common cold
• Allergic rhinitis (hay fever)
• Sinusitis
• Upper respiratory tract infections

This product comes in a 10ml metered dose spray bottle, which ensures accurate delivery and prevents overuse. It is intended for children aged between 2 to 12 years (depending on regional guidelines) and should only be used under adult supervision.

Xylometazoline acts quickly—usually within minutes—and its effect can last up to 10 hours, providing sustained relief and helping children breathe more easily, especially during sleep or feeding.

How to use OTRIVIN 0.05% (Children)

Proper administration of OTRIVIN ensures both efficacy and safety. Follow these steps for correct usage:

• Before first use: Prime the spray by pressing the pump several times until a uniform mist appears.
• Preparation: Ask the child to gently blow their nose to clear the nostrils.
• Positioning: Have the child tilt their head slightly forward. Insert the nozzle gently into one nostril.
• Spraying: While the child breathes in gently, press the spray once. Avoid directing the spray toward the nasal septum to prevent irritation.
• Repeat: Repeat the process for the other nostril if required.
• Post-application: Clean the nozzle with a tissue and replace the protective cap.

Do not exceed the recommended number of applications. Prolonged or excessive use can lead to rebound congestion and mucosal damage.

Mode of Action OTRIVIN 0.05% (Children)

Xylometazoline HCl is a sympathomimetic agent that acts on alpha-adrenergic receptors in the nasal mucosa. Its primary actions include:

• Vasoconstriction: Xylometazoline causes constriction of the blood vessels in the nasal passages, leading to reduced swelling and congestion.
• Decreased mucus secretion: By reducing blood flow to the mucosa, it indirectly minimizes mucus production.
• Rapid onset: The decongestant effect starts within 5–10 minutes of application.
• Prolonged duration: The effect can last up to 8–10 hours, offering prolonged relief.

This local action minimizes systemic absorption, making it safer for pediatric use when dosed appropriately.

OTRIVIN 0.05% (Children) Interactions OTRIVIN 0.05% (Children)

While topical, Xylometazoline may still interact with certain medications, especially those that affect the sympathetic nervous system. Key considerations include:

• Monoamine Oxidase Inhibitors (MAOIs): Concurrent use may lead to hypertensive crisis due to potentiation of vasoconstrictive effects. Avoid use within 14 days of stopping MAOIs.
• Tricyclic Antidepressants (TCAs): May enhance the sympathomimetic activity of Xylometazoline, increasing the risk of cardiovascular effects.
• Beta-Blockers: These can mask symptoms of adverse cardiovascular effects, such as increased heart rate or blood pressure.
• Antihypertensive Drugs: May have reduced effectiveness if used concurrently with Xylometazoline due to vasoconstrictive action.

Always inform your pediatrician of all medications your child is taking before using OTRIVIN nasal spray.

Dosage of OTRIVIN 0.05% (Children)

The dosage must be tailored to the child’s age and medical condition. General guidelines are as follows:

• Children aged 2 to 12 years: One spray in each nostril, up to 2–3 times per day.
• Maximum duration: Do not use for more than 5 consecutive days. Prolonged use may lead to rebound congestion (rhinitis medicamentosa).
• Minimum interval: Allow at least 8 to 10 hours between doses.
• Supervision: Always administer under the guidance of an adult to ensure correct usage and to prevent overdose.

Do not increase the dose or frequency unless directed by a healthcare professional.

Possible side effects of OTRIVIN 0.05% (Children)

Although generally well tolerated, OTRIVIN may cause some side effects, especially with prolonged or incorrect use:

• Common side effects:
  • Local nasal irritation or burning sensation
  • Sneezing
  • Dryness of the nasal mucosa
• Less common:
  • Headache
  • Nausea
  • Sleep disturbances or restlessness (especially in sensitive children)
• Rare but serious:
  • Rebound congestion with prolonged use
  • Increased heart rate or blood pressure
  • Allergic reaction (rash, swelling, difficulty breathing)

Discontinue use and consult a doctor if any severe or persistent symptoms occur.

OTRIVIN 0.05% (Children) Contraindications OTRIVIN 0.05% (Children)

Use of OTRIVIN 0.05% (Children) is contraindicated in the following cases:

• Hypersensitivity: Known allergy to Xylometazoline or any component of the spray.
• Recent nasal surgery or trauma: May impair healing or worsen symptoms.
• Glaucoma: Especially angle-closure glaucoma, as decongestants may increase intraocular pressure.
• Cardiovascular disease: Use with caution in children with pre-existing heart conditions or hypertension.
• Hyperthyroidism or diabetes: Conditions that may be exacerbated by systemic absorption of sympathomimetic agents.

Always consult with a pediatrician before beginning treatment to rule out any underlying contraindications.

Storage of OTRIVIN 0.05% (Children)

Proper storage of OTRIVIN ensures the medication remains effective and safe for use:

• Temperature: Store at room temperature, ideally between 15°C and 25°C (59°F to 77°F).
• Avoid freezing: Do not freeze. Freezing may damage the formulation or dispenser mechanism.
• Keep upright: Store the bottle upright to maintain proper function of the metered spray.
• Protect from sunlight: Keep out of direct sunlight and heat sources.
• Child safety: Store out of reach of children to prevent accidental ingestion or overdose.
• Shelf-life: Use within the expiry date printed on the packaging. Discard the bottle if the spray changes color, consistency, or odor.

Do not share the spray with others to avoid contamination and transmission of infection.