Otri Allergy AQUEOUS NASAL SPRAY Nasal Spray

What is Otri Allergy AQUEOUS NASAL SPRAY

Otri Allergy AQUEOUS NASAL SPRAY is a nasal corticosteroid spray that contains the active ingredient Fluticasone propionate. It is commonly used to relieve symptoms of allergic rhinitis, including sneezing, nasal congestion, runny nose, and nasal itching caused by allergens such as pollen (seasonal), dust mites, pet dander, and mold (perennial).

• Form: Aqueous nasal spray (non-drying), 120 metered doses per bottle.
• Generic Name: Fluticasone propionate, a potent synthetic corticosteroid.
• Primary Use: Treats both seasonal and year-round allergic rhinitis symptoms.
• Action: Reduces inflammation, swelling, and mucus production in the nasal passages.
• Suitable For: Adults and children above a certain age (varies by country, often 4+ years).
• Non-sedating: Unlike antihistamines, it does not cause drowsiness.

With regular use, Otri Allergy AQUEOUS NASAL SPRAY can significantly improve quality of life for individuals suffering from persistent or severe nasal allergies.

How to use Otri Allergy AQUEOUS NASAL SPRAY

Correct usage ensures maximum effectiveness and reduces the risk of side effects. Follow these steps carefully:

• Preparation: Shake the bottle gently. If it’s the first time or hasn’t been used for several days, prime the spray by pumping it into the air until a fine mist appears.
• Blow your nose: Gently clear your nasal passages before spraying.
• Positioning: Tilt your head slightly forward. Hold the spray upright and insert the nozzle into one nostril. Close the other nostril with your finger.
• Application: Breathe in gently through your nose while pressing down on the pump to release the spray. Avoid spraying directly onto the nasal septum.
• Repeat: Administer the prescribed number of sprays in each nostril. Repeat the process for the other nostril if required.
• Post-application: Avoid blowing your nose immediately after use to allow absorption.
• Cleaning: Wipe the nozzle after each use and replace the cap securely.

Always follow your healthcare provider’s instructions regarding dosage and frequency. This medication works best when used consistently.

Mode of Action Otri Allergy AQUEOUS NASAL SPRAY

Fluticasone propionate, the active component in Otri Allergy AQUEOUS NASAL SPRAY, is a glucocorticoid that exerts strong anti-inflammatory effects. Its action is localized in the nasal mucosa, helping to control allergic symptoms effectively.

• Receptor Binding: Fluticasone binds to intracellular glucocorticoid receptors in nasal epithelial cells.
• Inhibition of Inflammatory Mediators: It suppresses the release of substances such as histamine, prostaglandins, and leukotrienes that cause inflammation and allergy symptoms.
• Reduced Vascular Permeability: Helps to decrease nasal congestion by preventing fluid leakage into nasal tissues.
• Decreased Immune Cell Infiltration: Limits the accumulation of eosinophils, mast cells, and T-lymphocytes in the nasal mucosa.
• Local Action: Delivers direct relief at the site of inflammation with minimal systemic absorption.

Overall, the spray reduces the hypersensitivity response of the nasal passages to allergens, leading to a marked reduction in symptoms with daily use.

Otri Allergy AQUEOUS NASAL SPRAY Interactions Otri Allergy AQUEOUS NASAL SPRAY

Although Fluticasone has minimal systemic absorption when used intranasally, interactions can still occur, particularly with drugs that affect its metabolism.

• Strong CYP3A4 Inhibitors: Medications such as ritonavir (an HIV protease inhibitor) or ketoconazole (an antifungal) may inhibit the breakdown of Fluticasone, leading to increased levels and risk of systemic effects like adrenal suppression.
• Other Corticosteroids: Concomitant use of other corticosteroids (inhaled, oral, or topical) may increase the risk of systemic side effects such as Cushing’s syndrome or impaired adrenal function.
• Immunosuppressants: Using with other immune-modulating medications may increase susceptibility to infections.
• Vaccines: Corticosteroids may reduce the efficacy of live vaccines. Inform your healthcare provider before vaccination.
• Natural Supplements: Herbal supplements that affect liver enzymes (like St. John's Wort) may alter fluticasone metabolism.

Always inform your doctor or pharmacist about all the medicines and supplements you are taking before starting Otri Allergy AQUEOUS NASAL SPRAY.

Dosage of Otri Allergy AQUEOUS NASAL SPRAY

The dosage may vary depending on age, severity of symptoms, and individual response to treatment. Below are general guidelines:

• Adults and adolescents (12 years and older): The typical dose is 2 sprays in each nostril once daily (total of 4 sprays per day). Once symptoms are controlled, this may be reduced to 1 spray per nostril daily.
• Children (4 to 11 years): Commonly recommended dose is 1 spray in each nostril once daily. Children should only use the spray under adult supervision and per a doctor’s recommendation.
• Maximum dose: Should not exceed 2 sprays per nostril per day.
• Onset and duration: It may take 12 to 24 hours for symptom relief and up to several days for full effect. Continued daily use is important during allergy seasons or chronic exposure.
• Missed dose: If missed, use as soon as remembered. Skip if it’s close to the next scheduled dose. Never double dose.

Always follow your healthcare provider’s specific instructions and do not exceed the prescribed dose without medical advice.

Possible side effects of Otri Allergy AQUEOUS NASAL SPRAY

Most people tolerate Otri Allergy AQUEOUS NASAL SPRAY well, especially when used correctly. However, side effects may occur, particularly with long-term use.

• Common (1–10%):
  • Nasal dryness, irritation, or stinging
  • Sore throat or hoarseness
  • Nosebleeds (epistaxis)
  • Headache
• Less Common:
  • Bad taste or smell
  • Nasal septum perforation (rare, usually with overuse or improper use)
  • Delayed wound healing in the nasal mucosa
• Rare/Systemic Effects:
  • Adrenal suppression
  • Growth retardation in children (with prolonged use)
  • Visual disturbances (e.g., glaucoma, cataracts)
  • Allergic reactions such as rash, facial swelling, or difficulty breathing

Seek medical attention if you experience persistent nosebleeds, signs of infection, or allergic reactions.

Otri Allergy AQUEOUS NASAL SPRAY Contraindications Otri Allergy AQUEOUS NASAL SPRAY

Certain conditions may prevent the safe use of this medication. Do not use Otri Allergy AQUEOUS NASAL SPRAY if you have:

• Hypersensitivity: Allergy to Fluticasone propionate or any other ingredient in the product.
• Active nasal infections: Bacterial, fungal, or viral infections in the nasal cavity, unless properly treated.
• Recent nasal surgery or trauma: Use with caution as corticosteroids may delay wound healing.
• Untreated systemic infections: Corticosteroids may suppress the immune response.
• Children under approved age: Safety and efficacy in children younger than 4 years are not established.
• Pre-existing eye conditions: Glaucoma or cataracts may be worsened with corticosteroid use.

Always consult with a healthcare provider before starting treatment, especially if you have chronic medical conditions or are on other long-term medications.

Storage of Otri Allergy AQUEOUS NASAL SPRAY

Proper storage is essential to maintain the spray’s effectiveness and prevent contamination.

• Temperature: Store at room temperature, ideally between 15°C to 25°C (59°F to 77°F).
• Avoid freezing: Freezing may damage the pump mechanism and alter the solution’s properties.
• Protect from sunlight: Keep the bottle away from direct sunlight and sources of excessive heat.
• Keep the cap on: Replace the protective cap after each use to prevent dust and contamination.
• Child safety: Store out of reach of children.
• Expiration: Do not use after the expiration date printed on the label. Dispose of unused spray after completing the prescribed duration or once the 120 doses have been used.

Discard safely and follow local guidelines for medication disposal if necessary.