Otri Allergy AQUEOUS NASAL SPRAY Nasal Spray

What is Otri Allergy AQUEOUS NASAL SPRAY

Otri Allergy AQUEOUS NASAL SPRAY is a corticosteroid nasal spray containing the active ingredient Fluticasone propionate. It is designed to provide relief from the symptoms of allergic rhinitis, including nasal congestion, sneezing, runny nose, and itching. This medication is widely used for both seasonal allergies (such as hay fever) and perennial allergic rhinitis caused by indoor allergens like dust mites, pet dander, or molds.

• Contains Fluticasone propionate, a synthetic corticosteroid with potent anti-inflammatory properties.
• Delivered as a 60-dose nasal spray, making it convenient for regular daily use.
• Helps reduce inflammation and swelling inside the nasal passages, allowing easier breathing.
• Effective in controlling allergy symptoms and improving quality of life for allergy sufferers.
• Available over the counter or by prescription depending on local regulations.
• Suitable for adults and children (age restrictions vary by country and should be checked with healthcare providers).

How to use Otri Allergy AQUEOUS NASAL SPRAY

Using Otri Allergy nasal spray correctly is essential for maximum effectiveness and minimizing side effects. Follow these instructions carefully:

• Shake the bottle: Before each use, gently shake the spray bottle to mix the medication evenly.
• Prime the pump: If using for the first time or after a period of non-use, spray into the air away from your face until a fine mist appears.
• Clear your nose: Blow your nose gently to clear nasal passages before administration.
• Proper positioning: Tilt your head slightly forward and insert the nozzle into one nostril, aiming slightly away from the nasal septum (the center cartilage).
• Administration: While breathing in gently through your nose, press the pump firmly to release the spray.
• Repeat: If prescribed, repeat in the other nostril.
• Avoid blowing your nose immediately after use: Wait a few minutes to allow the medication to absorb.
• Frequency: Typically used once or twice daily as directed by your healthcare provider.
• Cleaning: Wipe the nozzle after each use and replace the cap to keep it clean.

Mode of Action Otri Allergy AQUEOUS NASAL SPRAY

Otri Allergy nasal spray contains Fluticasone propionate, which is a potent corticosteroid with anti-inflammatory effects. Its mode of action involves:

• Glucocorticoid receptor binding: Fluticasone binds to glucocorticoid receptors in the nasal mucosa cells, initiating a complex chain of anti-inflammatory responses.
• Suppression of inflammatory mediators: It inhibits the release of histamines, prostaglandins, leukotrienes, and cytokines that drive the allergic inflammatory process.
• Reduction of immune cell recruitment: The drug reduces the migration and activation of immune cells like eosinophils and mast cells to the nasal lining.
• Decreased vascular permeability: This reduces nasal swelling and congestion by limiting fluid leakage from blood vessels.
• Overall effect: The result is diminished nasal inflammation, less mucus production, and relief from allergy symptoms such as sneezing, itching, and congestion.
• Because it acts locally, systemic absorption is minimal, limiting systemic side effects compared to oral corticosteroids.

Otri Allergy AQUEOUS NASAL SPRAY Interactions Otri Allergy AQUEOUS NASAL SPRAY

Fluticasone propionate nasal spray has minimal systemic absorption, so significant drug interactions are uncommon. Nevertheless, consider the following points:

• Other corticosteroids: Using multiple corticosteroids (nasal, inhaled, oral, or topical) simultaneously may increase the risk of systemic side effects; inform your doctor if you are using other corticosteroids.
• CYP3A4 inhibitors: Fluticasone is metabolized in the liver by the CYP3A4 enzyme. Potent inhibitors such as ketoconazole, ritonavir, or clarithromycin may increase fluticasone levels, potentially increasing side effects.
• Immunosuppressants: Concurrent use with other immunosuppressive drugs can increase the risk of infections.
• Vaccines: Live vaccines should be used cautiously as corticosteroids may reduce immune response.
• Inform healthcare providers: Always disclose your use of Otri Allergy nasal spray before starting new medications.

Dosage of Otri Allergy AQUEOUS NASAL SPRAY

The dosage of Otri Allergy nasal spray depends on age, severity of symptoms, and clinical guidance. Typical dosing guidelines include:

• Adults and adolescents (12 years and older): Usually 2 sprays in each nostril once daily. Some patients may require 1 spray twice daily or 2 sprays twice daily initially.
• Children (usually 4 to 11 years): Dose is often 1 spray in each nostril once daily, but this can vary by local recommendations.
• Maintenance: After symptoms improve, the dose may be reduced to the lowest effective amount.
• Missed dose: Take it as soon as you remember. Do not double the dose to catch up.
• Duration: Can be used for seasonal allergy periods or year-round in perennial allergic rhinitis, as directed by a physician.
• Always follow your healthcare provider's instructions for dosing and duration to optimize safety and effectiveness.

Possible side effects of Otri Allergy AQUEOUS NASAL SPRAY

Although generally safe, some patients may experience side effects, mostly mild and localized:

• Nasal irritation: Burning, dryness, or stinging sensation inside the nose.
• Nosebleeds: Occasional mild epistaxis (nosebleeds), especially with prolonged use.
• Throat irritation: Sore throat or hoarseness can occur.
• Headache: Some users report mild headaches.
• Uncommon: Nasal septum perforation with long-term excessive use, infections, or hypersensitivity reactions.
• Systemic effects: Rare but possible, such as adrenal suppression or growth retardation in children, mainly with high doses or prolonged use.
• Seek medical attention if you experience severe allergic reactions, vision changes, persistent nosebleeds, or signs of infection.

Otri Allergy AQUEOUS NASAL SPRAY Contraindications Otri Allergy AQUEOUS NASAL SPRAY

Otri Allergy nasal spray should not be used under the following conditions:

• Hypersensitivity: Known allergy to fluticasone propionate or any ingredient in the formulation.
• Untreated nasal infections: Active viral, bacterial, or fungal infections of the nasal passages should be treated before use.
• Nasal trauma or surgery: Recent nasal septum ulcers, wounds, or surgery should be considered before initiating treatment.
• Children under recommended age: Use in children below the specified age limit is not advised without medical supervision.
• Use caution in patients with glaucoma or cataracts as corticosteroids may exacerbate these conditions.

Storage of Otri Allergy AQUEOUS NASAL SPRAY

Proper storage maintains the safety and effectiveness of Otri Allergy nasal spray:

• Temperature: Store at room temperature, generally between 15°C to 25°C (59°F to 77°F).
• Protect from light: Keep the bottle away from direct sunlight and heat sources.
• Keep the bottle tightly closed: To prevent contamination and evaporation of the solution.
• Avoid freezing: Do not freeze the nasal spray as it may damage the formulation and spray mechanism.
• Keep out of reach of children: To avoid accidental misuse or ingestion.
• Discard after expiration date: Do not use the spray beyond its expiry date, and discard any leftover solution after the prescribed course or after 60 doses are used.