OSTENIL 1% Injection/Intraarticular

What is OSTENIL 1%

OSTENIL 1% is a sterile, transparent, viscoelastic solution designed for intra-articular injection. It contains sodium hyaluronate 1%, a substance that occurs naturally in the human body, particularly in joint synovial fluid and connective tissues. It is available in a 2ml pre-filled syringe and is primarily used in the management of osteoarthritis and joint pain.

• Category: Viscosupplement
• Generic Name: Sodium hyaluronate
• Indications: Treatment of mild to moderate osteoarthritis, relief of joint pain, and improvement in joint mobility.
• Mechanism: Supplements the body's natural synovial fluid to restore viscosity and lubrication in the joint.

OSTENIL is often recommended for patients who do not respond adequately to other non-invasive treatments such as NSAIDs or physical therapy.

How to use OSTENIL 1%

OSTENIL 1% should be administered only by qualified healthcare professionals in a clinical setting. The product is for intra-articular use only and is injected directly into the joint cavity.

• Ensure the product is at room temperature before use.
• Disinfect the injection site thoroughly prior to administration.
• Aseptic technique must be maintained throughout the procedure.
• The 2ml pre-filled syringe is intended for single use only.
• Typically injected into the knee joint but may be used in other joints as clinically appropriate.

Post-injection, patients are often advised to avoid strenuous activity for 48 hours. Symptom relief is typically noticeable within days and may last several months depending on the patient’s condition and lifestyle.

Mode of Action OSTENIL 1%

Sodium hyaluronate in OSTENIL 1% acts by restoring the viscoelastic properties of synovial fluid in arthritic joints.

• Lubrication: It enhances joint lubrication, which reduces friction and eases movement.
• Shock absorption: Provides cushioning for the joint during weight-bearing activities.
• Cell support: Supports the proliferation and functioning of synoviocytes and chondrocytes.
• Anti-inflammatory: Modulates inflammatory processes in the joint.

This mechanism helps to alleviate pain, improve joint mobility, and potentially slow the progression of degenerative changes in osteoarthritis.

OSTENIL 1% Interactions OSTENIL 1%

OSTENIL 1% generally has a low potential for systemic drug interactions due to its local application. However, certain considerations are important:

• Intra-articular corticosteroids: Avoid co-administration to reduce the risk of infection or adverse joint reactions.
• Topical antiseptics: Do not use quaternary ammonium salts (e.g., benzalkonium chloride) to disinfect the injection site; these may cause precipitation of sodium hyaluronate.
• Oral medications: No known interaction, but inform your doctor of all ongoing medications.
• Joint lavage products: Should not be combined with OSTENIL in the same session unless specifically directed by a physician.

Always inform your healthcare provider about all medications and supplements you are taking before receiving an OSTENIL injection.

Dosage of OSTENIL 1%

OSTENIL 1% is typically administered as follows:

• Dosage Form: 2ml pre-filled syringe containing 20mg of sodium hyaluronate (1% solution)
• Typical Schedule: One intra-articular injection per week, for a total of 1 to 3 injections depending on clinical response.
• Joint-specific use: Most commonly injected into the knee, but can also be used in the hip, shoulder, or other synovial joints.
• Repeat Courses: May be repeated every 6–12 months if symptoms recur.

The dosage should always be individualized based on the patient's clinical condition and response to treatment.

Possible side effects of OSTENIL 1%

OSTENIL 1% is generally well tolerated, but like all injectable treatments, it may cause certain side effects:

• Common: Mild to moderate pain, swelling, or stiffness at the injection site.
• Less common: Warmth, redness, or a sensation of joint fullness post-injection.
• Rare: Hypersensitivity reactions such as rash or itching.
• Serious (rare): Septic arthritis, if aseptic technique is not properly maintained during injection.

Most side effects are temporary and self-limiting. Patients should report prolonged or severe symptoms to their healthcare provider immediately.

OSTENIL 1% Contraindications OSTENIL 1%

OSTENIL 1% should not be used in the following conditions:

• Known allergy to sodium hyaluronate or any of the excipients.
• Infection at the injection site or ongoing skin disease in the area of injection.
• Septic arthritis or active joint infections.
• Bleeding disorders or patients on anticoagulants without proper monitoring.

Caution is advised in patients with autoimmune joint disorders and those with significant joint effusion. Always assess patient history thoroughly before proceeding with treatment.

Storage of OSTENIL 1%

Proper storage of OSTENIL 1% is crucial to maintain its efficacy and sterility:

• Storage temperature: Store at 2°C to 25°C. Do not freeze.
• Packaging: Keep the syringe in its original packaging to protect from light.
• Use-by date: Do not use after the expiry date printed on the packaging.
• Single-use only: Discard any unused portion. Do not reuse.

OSTENIL should be kept out of reach of children and should only be handled by healthcare professionals trained in intra-articular injections.