OSPEN 400 Suspension/Granules for

What is OSPEN 400

OSPEN 400 is an oral suspension formulation that contains Phenoxymethylpenicillin potassium—a narrow-spectrum beta-lactam antibiotic belonging to the penicillin class. It is primarily used for treating mild to moderately severe bacterial infections caused by penicillin-sensitive microorganisms. OSPEN 400 is commonly prescribed in pediatric populations due to its convenient liquid form and effective antibacterial properties.

• Generic Name: Phenoxymethylpenicillin potassium
• Brand Name: OSPEN 400
• Form: Granules for oral suspension
• Packaging: 60ml glass bottle after reconstitution
• Therapeutic Class: Antibiotic (Beta-lactam/Penicillin)

It is often prescribed to treat infections such as:

• Upper respiratory tract infections (e.g., tonsillitis, pharyngitis)
• Skin and soft tissue infections
• Scarlet fever
• Rheumatic fever prophylaxis

OSPEN 400 is not effective against beta-lactamase-producing bacteria and should be used strictly under medical supervision.

How to use OSPEN 400

Correct usage of OSPEN 400 is crucial to achieving optimal therapeutic outcomes. The suspension should be prepared and administered following your healthcare provider’s instructions.

• Preparation: Shake the bottle well before reconstituting. Add the required amount of water in two portions, shaking vigorously after each addition to ensure uniform mixing.
• Dosing: Use a calibrated dosing spoon or oral syringe to measure the exact dose.
• Administration: Administer orally, preferably on an empty stomach, about 1 hour before or 2 hours after meals for better absorption.
• Shaking: Shake the bottle well before each use to evenly distribute the medication.
• Full Course: Complete the full course as prescribed, even if symptoms improve early, to prevent bacterial resistance.

Always consult your doctor or pharmacist for specific instructions tailored to the patient's age, weight, and infection type.

Mode of Action OSPEN 400

Phenoxymethylpenicillin, the active ingredient in OSPEN 400, exerts its antibacterial effects by interfering with the synthesis of bacterial cell walls.

• Mechanism: Binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall.
• Inhibition: Inhibits the final transpeptidation step of peptidoglycan synthesis, weakening the bacterial cell wall.
• Result: Leads to cell lysis and death of susceptible bacteria (bactericidal action).

Phenoxymethylpenicillin is most effective against Gram-positive organisms and some Gram-negative cocci. It is not resistant to penicillinase enzymes, which limits its use to non-resistant bacterial strains.

OSPEN 400 Interactions OSPEN 400

Drug interactions may affect the efficacy of OSPEN 400 or increase the risk of side effects. Inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements.

• Probenecid: May increase blood levels of penicillin by inhibiting renal excretion, enhancing efficacy but also side effects.
• Oral contraceptives: Penicillins may reduce the efficacy of hormonal birth control; additional contraceptive methods may be needed.
• Anticoagulants (e.g., warfarin): Penicillins may prolong bleeding time in some individuals.
• Tetracyclines: May antagonize the bactericidal effect of penicillin when co-administered.
• Methotrexate: Penicillin may decrease renal clearance of methotrexate, increasing its toxicity.

Always consult your doctor or pharmacist before starting or stopping any medications while using OSPEN 400.

Dosage of OSPEN 400

Dosage of OSPEN 400 depends on factors such as age, body weight, severity of infection, and renal function. Always follow the prescribed dosage instructions carefully.

• Children (standard dosing): 25,000 to 50,000 IU/kg/day in divided doses every 6–8 hours.
• Adults: Although OSPEN 400 is primarily used in pediatric populations, adults may receive similar dosages adjusted for weight and condition.
• Maximum dose: Should not exceed the recommended limit unless under strict medical supervision.
• Renal impairment: Dosage adjustment may be necessary based on creatinine clearance.

Important: Never skip doses and do not double up if a dose is missed. Adherence is crucial for treatment success.

Possible side effects of OSPEN 400

OSPEN 400 is generally well tolerated but may cause some adverse effects, especially in those with allergies or sensitivities to penicillin.

• Common side effects:
  • Gastrointestinal disturbances (nausea, vomiting, diarrhea)
  • Skin rash
  • Headache
• Allergic reactions:
  • Hives, itching
  • Swelling of lips, face, or tongue
  • Anaphylaxis (rare but serious)
• Other rare effects:
  • Fever, joint pain
  • Hematological reactions (e.g., anemia, leukopenia)
  • Seizures (in high doses or renal impairment)

If any severe side effects or allergic symptoms occur, discontinue use immediately and seek emergency medical attention.

OSPEN 400 Contraindications OSPEN 400

OSPEN 400 should not be used in individuals with certain medical conditions or known hypersensitivities.

• Allergy to penicillins: Absolute contraindication due to risk of anaphylaxis.
• Hypersensitivity to cephalosporins: Cross-reactivity may occur in some patients.
• Severe renal impairment: Use with caution or avoid unless dose adjustment is possible.
• History of severe gastrointestinal disease: Especially colitis associated with antibiotics.

Always review the patient’s medical history carefully before prescribing OSPEN 400.

Storage of OSPEN 400

Proper storage ensures the medication remains effective throughout its course of use.

• Before reconstitution: Store in a dry place at room temperature (15°C – 25°C), away from moisture and direct sunlight.
• After reconstitution: Keep refrigerated between 2°C – 8°C (not frozen) and use within 7 days.
• Shake well before each use: Ensure uniform distribution of the medicine.
• Keep out of reach of children: Store safely to avoid accidental ingestion.
• Do not use expired medication: Dispose of properly if unused after 7 days of reconstitution.

Follow the storage guidelines printed on the package insert or consult your pharmacist for clarification.