What is ALGHAPHAN
- Compound & Class: Dextropropoxyphene hydrochloride is a weak synthetic opioid analgesic, chemically related to methadone, used for mild to moderate pain relief and as an antitussive agent :contentReference[oaicite:1]{index=1}.
- Formulation: Provided as a sterile injectable solution in 2 mL ampoules (10 per pack), typically administered intravenously or intramuscularly in a clinical setting.
- History: First introduced in the late 1950s by Eli Lilly under brand names like Darvon; historically used both alone and in combination with analgesics like paracetamol :contentReference[oaicite:2]{index=2}.
- Regulatory Status: Withdrawn from many markets (including EU, US, UK) due to safety concerns, particularly risk of fatal arrhythmias and overdose; infusion forms may still be allowed in specific regions under strict conditions :contentReference[oaicite:3]{index=3}.
- Primary Use: Short-term management of mild to moderate pain, symptomatic relief pre/post procedure, and occasional use for cough suppression or easing mild opioid withdrawal :contentReference[oaicite:4]{index=4}.
How to use ALGHAPHAN
ALGHAPHAN must be administered under strict clinical supervision:
- Route: Administered via IV or IM injection by trained healthcare personnel.
- Preparation: Inspect the ampoule for damage or particulate matter, use aseptic technique.
- Dilution: May be administered as is or diluted per institutional protocol—verify concentration before dosing.
- Monitoring: Continuous assessment of respiration, oxygenation, blood pressure, heart rate, and ECG—given cardiovascular risk.
- Timing: Given based on pain intensity or procedural needs; not for routine outpatient use due to cardiovascular and overdose risk.
- Opioid Precautions: Monitor for respiratory depression; have naloxone available for overdose reversal.
- Discontinuation: Do *not* stop abruptly after repeated doses; tapering may be required to avoid withdrawal symptoms :contentReference[oaicite:5]{index=5}.
Mode of Action ALGHAPHAN
- Opioid Receptor Agonist: Stimulates mu-opioid receptors in the CNS to inhibit pain signal transmission :contentReference[oaicite:6]{index=6}.
- Antitussive Effect: Levo-isomer contributes to mild cough suppression :contentReference[oaicite:7]{index=7}.
- Local Anaesthetic Properties: Exhibits sodium-channel blocking effect (similar to lidocaine), contributing to analgesia and cardiac conduction effects :contentReference[oaicite:8]{index=8}.
- Metabolism: Primarily hepatic (CYP3A4), converted to norpropoxyphene—which has a long half-life and contributes to toxicity and cardiac effects :contentReference[oaicite:9]{index=9}.
ALGHAPHAN Interactions ALGHAPHAN
- CNS Depressants: Concomitant alcohol, benzodiazepines, barbiturates, or other opioids may enhance sedation and respiratory depression.
- Cardiotoxic Agents: Additive risk with antiarrhythmics or drugs prolonging QRS/QT intervals due to sodium-channel and cardiac conduction effects :contentReference[oaicite:10]{index=10}.
- CYP3A4 Modulators: Enzyme inhibitors (e.g., certain azoles, some macrolides) can increase drug levels; inducers (e.g., rifampin, carbamazepine) may reduce efficacy.
- Withdrawal Risk: Methadone or other opioids may overlap, but abrupt switching may precipitate withdrawal; careful transition protocols advised.
Dosage of ALGHAPHAN
- Adults: Typical starting dose ranges from 50–100 mg IV/IM, adjusted to pain control—roughly equivalent to 5–10 mg morphine.
- Elderly/Hepatic/Renal Impairment: Start at lower doses with extended intervals; due to accumulation risk of dextro- and norpropoxyphene.
- Max Limits: Cumulative dosing must be cautious—exceeding therapeutic range may lead to cardiotoxicity or overdose.
- Tapering: If used over time, gradually taper off to avoid withdrawal symptoms such as restlessness and cramps :contentReference[oaicite:11]{index=11}.
Possible side effects of ALGHAPHAN
- Common: Drowsiness, sedation, dizziness, nausea, constipation, sweating :contentReference[oaicite:12]{index=12}.
- Cardiovascular: Bradycardia, hypotension, QRS/QT prolongation, arrhythmias, syncope—especially from norpropoxyphene accumulation :contentReference[oaicite:13]{index=13}.
- Respiratory: Risk of respiratory depression—dose-dependent and needing monitoring.
- CNS Effects: Confusion, seizures (rare), potential dependency and withdrawal syndrome :contentReference[oaicite:14]{index=14}.
- Serious/Rare: Fatal overdose, circulatory collapse, pulmonary edema :contentReference[oaicite:15]{index=15}.
ALGHAPHAN Contraindications ALGHAPHAN
- Absolute: Known hypersensitivity, known or suspected cardiac conduction disorders (e.g., heart block, long-QT syndrome), respiratory depression.
- Relative: Severe hepatic or renal impairment, elderly, adolescents/children, respiratory conditions, concurrent CNS depressants.
- Withdrawn Products: Oral/parenteral forms often contraindicated in many countries; use only under tightly controlled clinical conditions :contentReference[oaicite:16]{index=16}.
Storage of ALGHAPHAN
- Temperature: Store between 15–25 °C; avoid freezing or heat exposure.
- Protection: Keep ampoules in original packaging to protect from light and contamination.
- Sterility: Use single-dose ampoules only once; discard any unused portions after opening.
- Expiry Monitoring: Discard expired units; adhere to institutional disposal protocols.
ALGHAPHAN features an exceptional active ingredient renowned for its potent effects, comprising Dextropropoxyphene HCl. This powerful formulation provides a superior solution for addressing diverse health concerns. With 75mg/Ampoule concentration and an easily manageable Injection/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALGHAPHAN .
Welcome to Dwaey, specifically on ALGHAPHAN page.
This medicine contains an important and useful components, as it consists of Dextropropoxyphene HCl.
ALGHAPHAN is available in the market in concentration 75mg/Ampoule and in the form of Injection/Solution for.
BOEHRINGER MANNHEIM GmbH is the producer of ALGHAPHAN and it is imported from GERMANY,
The most popular alternatives of ALGHAPHAN are listed downward .
-
Active Substance
-
Size
-
Indications
- No indications available.
-
Type
-
Company
Frequently Asked Questions
ALGHAPHAN should be stored according to the instructions provided by BOEHRINGER MANNHEIM GmbH.
In general, it is recommended to store ALGHAPHAN in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALGHAPHAN may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALGHAPHAN for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALGHAPHAN. Some medications, including
ALGHAPHAN, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALGHAPHAN, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALGHAPHAN without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALGHAPHAN if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALGHAPHAN during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 75mg/Ampoule,
and the specific recommendations of BOEHRINGER MANNHEIM GmbH.
The effects of ALGHAPHAN on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 75mg/Ampoule, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALGHAPHAN with or without food may vary depending on the medication
and the recommendations of BOEHRINGER MANNHEIM GmbH. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALGHAPHAN in children or elderly individuals may depend on various factors, including
the specific medication, type Injection/Solution for, and the recommendations of BOEHRINGER MANNHEIM GmbH. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALGHAPHAN in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
Related Products
0 Comments