ALFOSIN XR 10mg Tablets/Prolonged Release

What is ALFOSIN XR 10mg

ALFOSIN XR 10 mg is an extended‑release oral tablet containing the active ingredient Alfuzosin hydrochloride. It is used to alleviate lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in adult men. The XR (extended‑release) formulation enables once‑daily dosing by slowly releasing the drug over 24 hours.

• Generic Name: Alfuzosin hydrochloride
• Form: Prolonged‑release tablet
• Strength: 10 mg per tablet
• Packaging: 30 tablets per pack—suitable for one month’s treatment
• Therapeutic Class: α₁‑adrenergic receptor antagonist (selective)

Alfuzosin is indicated to:

• Relieve symptoms of BPH—such as urinary frequency, urgency, weak stream, and incomplete bladder emptying
• Improve uroflowmetry parameters and quality of life in BPH patients

Its extended‑release design offers stable blood levels, minimizing blood pressure fluctuations and enhancing patient adherence.

How to use ALFOSIN XR 10mg

Proper usage ensures optimal effectiveness and safety. Always follow your prescriber’s advice.

• Administration:
  • Swallow one 10 mg tablet whole once daily, ideally with food.
  • Do not split, crush, chew, or dissolve—the tablet has a special matrix to control absorption.
• Timing: Take it at the same time each day (e.g., after breakfast) to maintain steady drug levels.
• Missed Dose: If >12 hours have passed, skip and continue next day. Do not double up.
• Duration: Usually prescribed for months or years, depending on symptom relief and prostate condition.
• Monitoring: First-dose blood pressure should be checked, especially if at risk of hypotension.

Avoid abrupt discontinuation. Inform your doctor promptly if urinary symptoms worsen or side effects develop.

Mode of Action ALFOSIN XR 10mg

Alfuzosin is a selective antagonist of α₁‑adrenergic receptors located in the smooth muscle of the prostate gland, bladder neck, and urethra.

• Receptor Binding: Blocks α₁A and α₁D receptors—more concentrated in the prostate—reducing smooth muscle tone.
• Muscle Relaxation: Decreases tension in prostate and bladder neck, facilitating urine flow and reducing voiding pressure.
• Dynamic Component Relief: Eases the obstructive element of BPH rather than shrinking the prostate.
• Extended‑Release Benefit: The ER matrix ensures slow and constant release, minimizing peak-related side effects like hypotension.

This targeted action generally provides relief of LUTS without affecting the α₁ receptors in blood vessels (lower orthostatic hypotension risk).

ALFOSIN XR 10mg Interactions ALFOSIN XR 10mg

Alfuzosin may interact with other medications, potentially altering its effects or causing adverse events.

• Antihypertensives (e.g., ACE inhibitors, β‑blockers, diuretics): May increase hypotensive effects—monitor blood pressure closely.
• Nitrates (e.g., isosorbide): Combined use may cause significant drops in blood pressure.
• Phosphodiesterase‑5 inhibitors (e.g., sildenafil): Risk of symptomatic hypotension—use with caution and start at lower doses.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir): Can increase Alfuzosin levels—monitor patient; dose adjustment may be needed.
• Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): May reduce efficacy; therapy adjustment may be needed.

Always inform your physician of all prescription and OTC medications, supplements, and herbal remedies to avoid interactions.

Dosage of ALFOSIN XR 10mg

The recommended dose for adults with BPH is:

• Adults: One 10 mg prolonged‑release tablet once daily after the same meal.
• Elderly: No initial adjustment needed; monitor blood pressure.
• Renal Impairment: No adjustment necessary unless severe (creatinine clearance <10 mL/min); use with caution.
• Hepatic Impairment: Contraindicated in moderate-to-severe liver dysfunction due to reduced clearance.

Adjustments are rarely required thanks to the steady pharmacokinetic profile of the ER formulation. Regular clinical assessment should determine the need for continued treatment.

Possible side effects of ALFOSIN XR 10mg

Alfuzosin is usually well tolerated, but potential adverse effects may occur:

• Common (≥1–10%):
  • Dizziness, headache
  • Postural hypotension (especially during first week)
  • Fatigue
  • Nasopharyngitis
• Uncommon (≥0.1–1%):
  • Palpitations, tachycardia
  • Nausea, gastrointestinal discomfort
  • Edema
• Rare (<0.1%):
  • Priapism (painful, prolonged erection)
  • Severe hypotension or syncope
  • Allergic reactions (rash, pruritus, angioedema)

Seek medical attention if experiencing chest pain, fainting, or signs of severe allergic reaction. For bothersome symptoms, dosage may be adjusted or stopped.

ALFOSIN XR 10mg Contraindications ALFOSIN XR 10mg

Alfuzosin must not be used in the following conditions:

• Hypersensitivity: Known allergy to Alfuzosin or excipients.
• Severe liver impairment: Increased plasma concentrations pose safety risks.
• Coadministration with potent CYP3A4 inhibitors: Risk of excessive drug levels and toxicity.
• Hypotension or orthostatic conditions: May exacerbate symptoms.
• Concurrent alfuzosin-containing therapy: Avoid duplication.

Use with caution in mild-to-moderate hepatic or renal impairment. Inform your healthcare provider about any cardiovascular conditions before starting therapy.

Storage of ALFOSIN XR 10mg

Proper storage maintains the integrity and effectiveness of the medication.

• Temperature: Store at 15–30 °C (59–86 °F). Do not freeze.
• Packaging: Keep tablets in the original blister pack to protect from moisture and light.
• Child Safety: Keep out of reach and sight of children.
• Disposal: Dispose of unused tablets according to local regulations—do not flush or toss in normal waste.
• Expiry: Do not use after the expiration date marked on each blister.

Proper handling ensures safety and maximizes therapeutic benefit.