ALEVE Tablets/Film-coated

What is ALEVE

ALEVE is a brand name for a nonsteroidal anti-inflammatory drug (NSAID) containing Naproxen sodium as its active ingredient. It is commonly used to relieve pain, reduce inflammation, and bring down fever.

• Active Ingredient: Naproxen (as sodium) – a fast-absorbing salt form of Naproxen, providing quicker relief compared to standard Naproxen.
• Form: Tablets / Film-coated – designed for ease of swallowing and better gastrointestinal tolerance.
• Packaging: 12s blister – suitable for short-term treatment courses or acute pain episodes.

ALEVE is often used to treat conditions such as:

• Headaches (including migraines)
• Menstrual cramps
• Muscle aches and joint pain
• Backache
• Arthritis and other inflammatory conditions
• Dental pain
• Fever

As an over-the-counter (OTC) medication in many countries, ALEVE offers convenient access to powerful pain relief. However, it should still be used responsibly due to potential side effects and interactions.

How to use ALEVE

Proper use of ALEVE (Naproxen sodium) is essential for effective and safe relief. It should always be taken according to the package instructions or as directed by a healthcare provider.

• Dosage: Adults and children over 12 years: take 1 tablet (usually 220 mg) every 8 to 12 hours as needed. For the first dose, 2 tablets may be taken within the first hour, but do not exceed 2 tablets in any 8–12-hour period or 3 tablets in 24 hours.
• Take with food or milk: Although ALEVE can be taken with or without food, consuming it with food or milk can help reduce the risk of stomach upset.
• Do not crush or chew: Swallow film-coated tablets whole with a full glass of water.
• Use the lowest effective dose: Always use the smallest dose that is effective for your condition and for the shortest time possible to reduce the risk of side effects.

Important usage guidelines:

• Do not use for more than 10 consecutive days for pain or 3 days for fever without consulting a doctor.
• Avoid alcohol and other NSAIDs (like ibuprofen) while taking ALEVE, unless prescribed.
• If symptoms persist or worsen, seek medical attention.

Mode of Action ALEVE

ALEVE (Naproxen sodium) works by inhibiting the body's production of substances that cause pain and inflammation. Specifically, it targets the cyclooxygenase (COX) enzymes.

• COX Enzyme Inhibition: Naproxen blocks COX-1 and COX-2 enzymes, which are responsible for the formation of prostaglandins – chemical messengers that promote inflammation, pain, and fever.
• Anti-inflammatory Effects: By reducing prostaglandin synthesis, ALEVE effectively lowers inflammation in tissues and joints.
• Analgesic (Pain Relief): The suppression of pain signaling pathways provides rapid relief from various types of pain.
• Antipyretic (Fever Reduction): Naproxen helps lower elevated body temperature by acting on the hypothalamus (the body's thermostat in the brain).

Unlike some other NSAIDs, Naproxen has a relatively longer half-life (12–17 hours), which allows for twice-daily dosing, offering prolonged pain control compared to drugs like ibuprofen.

ALEVE Interactions ALEVE

Drug interactions may alter how ALEVE works or increase the risk of serious side effects. It’s crucial to be aware of potential interactions with common medications.

• Anticoagulants (e.g., Warfarin): Increased risk of bleeding. Naproxen may intensify the effects of blood thinners.
• Antihypertensives (e.g., ACE inhibitors, beta-blockers): ALEVE may reduce their effectiveness by promoting fluid retention and raising blood pressure.
• Diuretics (e.g., Furosemide): Concurrent use may reduce diuretic efficacy and increase risk of kidney damage.
• SSRIs (e.g., Fluoxetine): Combined use increases the risk of gastrointestinal bleeding.
• Methotrexate and Lithium: ALEVE may increase the levels and toxicity of these drugs.
• Other NSAIDs: Using multiple NSAIDs (e.g., ibuprofen, aspirin) may increase the risk of side effects without added benefit.

Always inform your doctor or pharmacist about all prescription drugs, over-the-counter medications, and herbal supplements you are taking before starting ALEVE.

Dosage of ALEVE

The dosage of ALEVE should be based on age, condition, and response to treatment. It is essential to follow medical or package instructions carefully.

• Adults and Children ≥12 years:
  • Initial dose: 1 tablet (220 mg) every 8 to 12 hours.
  • First dose option: 2 tablets (440 mg) may be taken within the first hour if needed.
  • Do not exceed 3 tablets (660 mg) in 24 hours unless directed by a healthcare provider.
• Children under 12: Use not recommended unless prescribed by a physician.
• Elderly: May require lower doses due to increased sensitivity and risk of kidney or gastrointestinal side effects.

In special conditions:

• Arthritis (chronic): May require long-term use under medical supervision with regular evaluation.
• Dysmenorrhea: Start with 2 tablets at onset of symptoms, then 1 tablet every 8–12 hours as needed.

Possible side effects of ALEVE

While ALEVE is generally well tolerated, some users may experience side effects ranging from mild to serious.

• Common side effects:
  • Upset stomach or heartburn
  • Nausea
  • Headache
  • Dizziness or drowsiness
• Less common but serious side effects:
  • Gastrointestinal bleeding or ulcers
  • Allergic reactions (rash, itching, swelling, breathing difficulty)
  • Kidney function impairment
  • Elevated blood pressure
  • Hepatic issues (rare liver enzyme elevation)
  • Cardiovascular risks (especially with long-term or high-dose use)

Seek immediate medical attention if you experience chest pain, shortness of breath, black/tarry stools, or signs of severe allergic reaction (e.g., swelling of the face or throat).

ALEVE Contraindications ALEVE

ALEVE is not suitable for everyone. It should be avoided in certain populations and medical conditions to prevent harm.

• Allergy to Naproxen or other NSAIDs: Including aspirin sensitivity (may cause bronchospasm or anaphylaxis).
• History of gastrointestinal bleeding or ulcers: Especially if NSAID-related.
• Severe kidney or liver disease where metabolism or excretion of the drug is compromised.
• Advanced heart failure or recent heart surgery (CABG): Due to risk of thrombotic events.
• Pregnancy (especially third trimester): May affect fetal circulation or labor.
• Children under 12: Use should be under direct medical supervision only.

Always discuss your medical history and current health conditions with a doctor or pharmacist before using ALEVE.

Storage of ALEVE

Proper storage of ALEVE ensures the medicine remains effective and safe to use.

• Store at room temperature: Ideally between 20°C to 25°C (68°F to 77°F).
• Avoid excessive heat or moisture: Do not store in the bathroom or near the kitchen sink.
• Keep in original packaging: Protects tablets from light and air exposure.
• Keep out of reach of children and pets: ALEVE, like all medications, should be secured in a safe place.
• Do not use past expiry date: Check blister packaging for printed expiration date before use.

Improper storage can lead to decreased potency and increased risk of side effects. Dispose of expired tablets responsibly through pharmacy take-back programs if available.