What is ALECENSA 150mg
ALECENSA 150 mg is the branded oral capsule formulation of **Alectinib hydrochloride**, a second-generation ALK (anaplastic lymphoma kinase) inhibitor approved for ALK-positive non–small cell lung cancer (NSCLC).
- Active Ingredient: Alectinib HCl (150 mg per capsule)
- Dosage Form: Oral capsules
- Packaging: 224 capsules (4 packs × 56 capsules)
- Indications: For adults with metastatic ALK-positive NSCLC, both as first-line or after progression on crizotinib; also approved adjuvant after surgical resection in high-risk patients :contentReference[oaicite:1]{index=1}
- Key Benefits: Specifically targets ALK-driven cancer, has high central nervous system penetration—helping control brain metastases—and offers improved progression-free survival and tolerability compared to earlier-generation ALK inhibitors :contentReference[oaicite:2]{index=2}
How to use ALECENSA 150mg
Proper administration is critical to maximize benefit and manage side effects.
- Recommended Dose: 600 mg twice daily (four 150 mg capsules per dose) :contentReference[oaicite:3]{index=3}
- With Food: Always take with a meal to ensure optimal absorption :contentReference[oaicite:4]{index=4}
- Swallow Whole: Capsules must be swallowed intact; do not open or crush :contentReference[oaicite:5]{index=5}
- Missed Dose: Skip missed doses; resume at scheduled time—do not double up :contentReference[oaicite:6]{index=6}
- Vomiting: If vomiting occurs, take next dose at regular time; do not repeat the dose :contentReference[oaicite:7]{index=7}
- Duration of Therapy: Continue until disease progression or unacceptable side effects :contentReference[oaicite:8]{index=8}
Regular follow-ups—including blood tests for liver function and creatine kinase, and monitoring heart rhythm—are recommended throughout treatment :contentReference[oaicite:9]{index=9}.
Mode of Action ALECENSA 150mg
Alectinib is a potent and selective ALK tyrosine kinase inhibitor with additional activity against RET, showing strong intracranial efficacy.
- ALK Inhibition: Blocks ALK fusion proteins (e.g., EML4‑ALK), thereby halting downstream oncogenic signaling (STAT3 and PI3K/AKT/mTOR pathways) :contentReference[oaicite:10]{index=10}
- CNS Penetration: Effectively crosses the blood–brain barrier and accumulates in the central nervous system (CNS), offering robust intracranial control :contentReference[oaicite:11]{index=11}
- Apoptosis & Growth Arrest: Inhibits tumor cell proliferation and triggers cell death
- Selective Targeting: High specificity for ALK leads to fewer off-target side effects compared to earlier ALK inhibitors :contentReference[oaicite:12]{index=12}
- RET Inhibition: Also blocks RET kinase—currently being explored in RET fusion-positive cancers :contentReference[oaicite:13]{index=13}
ALECENSA 150mg Interactions ALECENSA 150mg
Alectinib interacts primarily via CYP3A4 metabolism; caution is essential when combining with CYP modulators or QT-prolonging agents.
- CYP3A4 Inhibitors: e.g., ketoconazole or clarithromycin may slightly raise alectinib exposure, but reduce active M4 levels; overall effect minor :contentReference[oaicite:14]{index=14}
- CYP3A4 Inducers: e.g., rifampicin or St. John's Wort can reduce alectinib levels—should be avoided :contentReference[oaicite:15]{index=15}
- QT-Prolonging Drugs: Combination may increase cardiac risk—monitor ECG if used together :contentReference[oaicite:16]{index=16}
- Levothyroxine: May cause increased risk of side effects—monitor thyroid function :contentReference[oaicite:17]{index=17}
- Food Interactions: No specific food interactions identified; just take with a regular meal :contentReference[oaicite:18]{index=18}
Dosage of ALECENSA 150mg
The dosing strategy balances effective disease control with manageable side effects.
- Initial Dose: 600 mg orally twice daily with food (total 1200 mg/day) :contentReference[oaicite:19]{index=19}
- Dose Reductions: If intolerant, reduce first to 450 mg bid, then 300 mg bid—discontinue if 300 mg is not tolerated :contentReference[oaicite:20]{index=20}
- Special Populations: No general dose adjustment for renal impairment; in moderate/severe hepatic impairment, caution is advised and dose may be reduced :contentReference[oaicite:21]{index=21}
- Discontinuation Criteria: Permanently stop if interstitial lung disease/pneumonitis occurs :contentReference[oaicite:22]{index=22}
- Treatment Continuation: Maintain therapy until disease progression or unacceptable toxicity occurs :contentReference[oaicite:23]{index=23}
Possible side effects of ALECENSA 150mg
Alectinib is typically well tolerated, but several common and serious side effects may occur.
- Very Common (≥10%): Fatigue, constipation, peripheral edema, muscle pain, anemia, increased liver enzymes (ALT, AST) :contentReference[oaicite:24]{index=24}
- Common (1–10%): Bradycardia, photosensitivity, elevated creatine kinase, rare pneumonitis/interstitial lung disease :contentReference[oaicite:25]{index=25}
- Serious (≤1%): Severe hepatotoxicity (transaminases > Grade 3), interstitial lung disease, QT prolongation—monitor and interrupt treatment if needed :contentReference[oaicite:26]{index=26}
- Other Reactions: Mild nausea, dizziness, rash, myalgia, photosensitivity—manageable with supportive care :contentReference[oaicite:27]{index=27}
ALECENSA 150mg Contraindications ALECENSA 150mg
Alectinib should not be used in cases of known hypersensitivity to the drug or its components.
- Allergy: Contraindicated if there is a known hypersensitivity to Alectinib or capsule excipients :contentReference[oaicite:28]{index=28}
- Pregnancy: Not recommended; may harm fetus—effective contraception required for men and women during treatment and for 3 months following last dose :contentReference[oaicite:29]{index=29}
- Breastfeeding: Avoid, as safety is unknown—stop for at least one week post final dose :contentReference[oaicite:30]{index=30}
- Severe Hepatic Impairment: Use only if benefits justify risks—monitor liver function closely :contentReference[oaicite:31]{index=31}
- Interstitial Lung Disease History: Discontinue if new severe pulmonary symptoms occur :contentReference[oaicite:32]{index=32}
Storage of ALECENSA 150mg
Correct storage maintains stability and potency.
- Temperature: Store at room temperature, below 30 °C (86 °F) in a dry place :contentReference[oaicite:33]{index=33}
- Packaging: Keep capsules in original packaging to protect from light and moisture :contentReference[oaicite:34]{index=34}
- Refrigeration: Do not refrigerate or freeze
- Child Safety: Keep out of reach of children and pets
- Disposal: Do not flush; follow local regulations or consult pharmacist :contentReference[oaicite:35]{index=35}
- Expiry Awareness: Check the expiration date; do not use expired capsules
ALECENSA 150mg features an exceptional active ingredient renowned for its potent effects, comprising Alectinib HCl. This powerful formulation provides a superior solution for addressing diverse health concerns. With 150mg/Capsule concentration and an easily manageable Capsules, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALECENSA 150mg .
Welcome to Dwaey, specifically on ALECENSA 150mg page.
This medicine contains an important and useful components, as it consists of Alectinib HCl.
ALECENSA 150mg is available in the market in concentration 150mg/Capsule and in the form of Capsules.
F. HOFFMANN-LA ROCHE LTD. is the producer of ALECENSA 150mg and it is imported from SWITZERLAND,
The most popular alternatives of ALECENSA 150mg are listed downward .
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Active Substance
-
Size
224 (4 Packs x 56 s) Capsules
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Indications
- No indications available.
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Type
-
Company
F. HOFFMANN-LA ROCHE LTD.
Frequently Asked Questions
ALECENSA 150mg should be stored according to the instructions provided by F. HOFFMANN-LA ROCHE LTD..
In general, it is recommended to store ALECENSA 150mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALECENSA 150mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALECENSA 150mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALECENSA 150mg . Some medications, including
ALECENSA 150mg , may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALECENSA 150mg , take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALECENSA 150mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALECENSA 150mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALECENSA 150mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 150mg/Capsule,
and the specific recommendations of F. HOFFMANN-LA ROCHE LTD..
The effects of ALECENSA 150mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 150mg/Capsule, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALECENSA 150mg with or without food may vary depending on the medication
and the recommendations of F. HOFFMANN-LA ROCHE LTD.. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALECENSA 150mg in children or elderly individuals may depend on various factors, including
the specific medication, type Capsules, and the recommendations of F. HOFFMANN-LA ROCHE LTD.. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALECENSA 150mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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