ALBUMIN NOVONORDISK 5% Infusion

What is ALBUMIN NOVONORDISK 5%

ALBUMIN NOVONORDISK 5% is a sterile, isotonic colloid solution containing human albumin 5 g per 100 mL (i.e., ~12.5 g per 250 mL bottle), derived from pooled human plasma. It undergoes viral inactivation (e.g., pasteurization) to ensure safety.

• Pharmaceutical class: Plasma protein solution; colloid volume expander.
• Primary uses:
  • Hypovolemia due to trauma, surgery, or hemorrhage
  • Hypoalbuminemia with edema or fluid imbalance
  • Large-volume paracentesis in cirrhosis (prevention of circulatory dysfunction)
  • Burns (after initial crystalloid therapy)
  • ARDS, cardiopulmonary bypass, nephrotic syndrome, neonatal exchange transfusion
• Packaging: 250 mL single-use bottle containing 12.5 g albumin.
• Administration: Intravenous under medical supervision.

ALBUMIN 5% is used when restoration or maintenance of circulating volume is required, particularly when fluid shifts are involved, as the colloid nature maintains oncotic pressure without excessive fluid load.

How to use ALBUMIN NOVONORDISK 5%

ALBUMIN 5% must be administered intravenously by trained healthcare personnel using aseptic technique.

• Preparation:
  • Inspect visually—clear to slightly yellow, no cloudiness or particles (discard if abnormal).
  • Do not shake; warm to room temperature if large volumes are required. :contentReference[oaicite:1]{index=1}
• Infusion:
  • May use directly or dilute with 0.9% saline / 5% dextrose if needed. :contentReference[oaicite:2]{index=2}
  • Typical adult doses: 250–500 mL, infused at 1–2 mL/min—adjust per condition response. :contentReference[oaicite:3]{index=3}
  • In shock, faster infusion may be needed under strict monitoring. :contentReference[oaicite:4]{index=4}
• Monitoring during infusion:
  • Vital signs: blood pressure, heart rate, respiratory rate, temperature
  • Fluid balance: intake & output, urine output
  • Edema or pulmonary overload signs
• After infusion:
  • Dispose of any unused portion—single-use only.

Infusion rate and volume must be customized based on the patient's cardiovascular status, renal function, and ongoing losses.

Mode of Action ALBUMIN NOVONORDISK 5%

Human albumin is a key plasma protein that plays several vital physiological roles. The 5% solution is isotonic and primarily restores intravascular volume when plasma is lost.

• Oncotic pressure maintenance: Albumin contributes about 70–80% of plasma colloid osmotic pressure; administering albumin draws fluid into circulation. :contentReference[oaicite:5]{index=5}
• Volume expansion: Each mL infused increases plasma volume by about 1 mL. Beneficial in hypovolemia but less intense than 20% solutions. :contentReference[oaicite:6]{index=6}
• Carrier function: Binds and transports hormones, bilirubin, drugs, fatty acids, and maintains pH buffer. :contentReference[oaicite:7]{index=7}
• BurnSupport: Maintains plasma proteins long-term after capillary leak stabilization. :contentReference[oaicite:8]{index=8}

ALBUMIN 5% supports hemodynamic stability, promotes tissue perfusion, and replenishes plasma proteins while providing transport and buffering functions.

ALBUMIN NOVONORDISK 5% Interactions ALBUMIN NOVONORDISK 5%

Human albumin has minimal direct pharmacokinetic interactions but can influence drug dynamics and fluid status.

• Drug binding changes: Can displace drugs like warfarin, phenytoin, diazepam, increasing free levels. :contentReference[oaicite:9]{index=9}
• ACE inhibitors: Co-administration may precipitate hypotension due to volume expansion.
• Colloid co-administration: Combining with HES or dextrans may cause excessive volume—monitor carefully. :contentReference[oaicite:10]{index=10}
• Fluid shifts: May dilute electrolytes—monitor sodium, potassium, calcium. :contentReference[oaicite:11]{index=11}

Compatibility: May be administered with blood components or crystalloid solutions but must not be diluted with sterile water or mixed with amino acid or alcohol-containing solutions. :contentReference[oaicite:12]{index=12}

Dosage of ALBUMIN NOVONORDISK 5%

Dosage depends on clinical context, weight, and response. Total daily dose shouldn’t exceed 2 g/kg.

• Hypovolemia / Shock:
  • Adults: 250–500 mL (~12.5–25 g albumin) initially; may repeat after 15–30 min if needed. :contentReference[oaicite:13]{index=13}
  • Children: 4.5–6.8 mL/kg (≈0.2–0.3 g/kg), adjust by response. :contentReference[oaicite:14]{index=14}
• Hypoalbuminemia / Edema:
  • Adults: 250–500 mL (12.5–25 g) per day. :contentReference[oaicite:15]{index=15}
• Post-Paracentesis (Cirrhosis):
  • 8 g albumin per 1 000 mL ascites removed—250 mL per 8 g. :contentReference[oaicite:16]{index=16}
• Burns (after 24 h): 250–500 mL (12.5–25 g); adjust to maintain serum proteins. :contentReference[oaicite:17]{index=17}

Dosing must be guided by hemodynamic endpoints—blood pressure, urine output, central venous pressure—not just lab values. :contentReference[oaicite:18]{index=18}

Possible side effects of ALBUMIN NOVONORDISK 5%

Generally safe, but volume loading and infusion reactions may occur.

• Common: Fever, chills, rigors, flushing, nausea, headache, tachycardia, hypotension. Often mild and infusion-rate related. :contentReference[oaicite:19]{index=19}
• Volume overload: Edema, pulmonary congestion—especially in heart or renal failure. :contentReference[oaicite:20]{index=20}
• Electrolyte dilution: Possible hyponatremia, hypokalemia—monitor labs. :contentReference[oaicite:21]{index=21}
• Allergic/anaphylactic: Rare—urticaria, bronchospasm, hypotension. Stop infusion and treat if occurs. :contentReference[oaicite:22]{index=22}
• Hemodilution anemia: May worsen existing anemia—correct if needed. :contentReference[oaicite:23]{index=23}

Monitor vital signs, respiratory, and renal status. Slow or stop infusion at first sign of serious reaction.

ALBUMIN NOVONORDISK 5% Contraindications ALBUMIN NOVONORDISK 5%

• Absolute:
  • Hypersensitivity to albumin or excipients. :contentReference[oaicite:24]{index=24}
  • Severe anemia—risk of further dilution. :contentReference[oaicite:25]{index=25}
  • Decompensated heart failure, pulmonary edema. :contentReference[oaicite:26]{index=26}
• Use with caution:
  • Renal impairment
  • Hypertension
  • Bleeding disorders/esophageal varices
  • Concurrent ACE inhibitor
  • Pregnancy/lactation (Category C)—only if essential. :contentReference[oaicite:27]{index=27}
  • Pediatric (including neonates)—must be guided by specialist. :contentReference[oaicite:28]{index=28}

Evaluate cardiovascular and renal status before administration. Monitor closely throughout therapy.

Storage of ALBUMIN NOVONORDISK 5%

• Temperature: Store at 2–25 °C (36–77 °F); do not freeze. :contentReference[oaicite:29]{index=29}
• Protection from light: Keep in original carton.
• Handling:
  • Avoid shaking.
  • Inspect prior to use—discard cloudy or particulate-containing vials.
  • Once opened or accessed, use immediately—discard any remainder. :contentReference[oaicite:30]{index=30}
• Expiry: Check and do not use after date on vial.
• Disposal: Follow biomedical waste guidelines; do not flush or discard in household waste.