What is ALBUMIN NOVONORDISK 5%
ALBUMIN NOVONORDISK 5% is a sterile, isotonic colloid solution containing human albumin 5 g per 100 mL (i.e., ~12.5 g per 250 mL bottle), derived from pooled human plasma. It undergoes viral inactivation (e.g., pasteurization) to ensure safety.
- Pharmaceutical class: Plasma protein solution; colloid volume expander.
- Primary uses:
- Hypovolemia due to trauma, surgery, or hemorrhage
- Hypoalbuminemia with edema or fluid imbalance
- Large-volume paracentesis in cirrhosis (prevention of circulatory dysfunction)
- Burns (after initial crystalloid therapy)
- ARDS, cardiopulmonary bypass, nephrotic syndrome, neonatal exchange transfusion
- Packaging: 250 mL single-use bottle containing 12.5 g albumin.
- Administration: Intravenous under medical supervision.
ALBUMIN 5% is used when restoration or maintenance of circulating volume is required, particularly when fluid shifts are involved, as the colloid nature maintains oncotic pressure without excessive fluid load.
How to use ALBUMIN NOVONORDISK 5%
ALBUMIN 5% must be administered intravenously by trained healthcare personnel using aseptic technique.
- Preparation:
- Inspect visually—clear to slightly yellow, no cloudiness or particles (discard if abnormal).
- Do not shake; warm to room temperature if large volumes are required. :contentReference[oaicite:1]{index=1}
- Infusion:
- May use directly or dilute with 0.9% saline / 5% dextrose if needed. :contentReference[oaicite:2]{index=2}
- Typical adult doses: 250–500 mL, infused at 1–2 mL/min—adjust per condition response. :contentReference[oaicite:3]{index=3}
- In shock, faster infusion may be needed under strict monitoring. :contentReference[oaicite:4]{index=4}
- Monitoring during infusion:
- Vital signs: blood pressure, heart rate, respiratory rate, temperature
- Fluid balance: intake & output, urine output
- Edema or pulmonary overload signs
- After infusion:
- Dispose of any unused portion—single-use only.
Infusion rate and volume must be customized based on the patient's cardiovascular status, renal function, and ongoing losses.
Mode of Action ALBUMIN NOVONORDISK 5%
Human albumin is a key plasma protein that plays several vital physiological roles. The 5% solution is isotonic and primarily restores intravascular volume when plasma is lost.
- Oncotic pressure maintenance: Albumin contributes about 70–80% of plasma colloid osmotic pressure; administering albumin draws fluid into circulation. :contentReference[oaicite:5]{index=5}
- Volume expansion: Each mL infused increases plasma volume by about 1 mL. Beneficial in hypovolemia but less intense than 20% solutions. :contentReference[oaicite:6]{index=6}
- Carrier function: Binds and transports hormones, bilirubin, drugs, fatty acids, and maintains pH buffer. :contentReference[oaicite:7]{index=7}
- BurnSupport: Maintains plasma proteins long-term after capillary leak stabilization. :contentReference[oaicite:8]{index=8}
ALBUMIN 5% supports hemodynamic stability, promotes tissue perfusion, and replenishes plasma proteins while providing transport and buffering functions.
ALBUMIN NOVONORDISK 5% Interactions ALBUMIN NOVONORDISK 5%
Human albumin has minimal direct pharmacokinetic interactions but can influence drug dynamics and fluid status.
- Drug binding changes: Can displace drugs like warfarin, phenytoin, diazepam, increasing free levels. :contentReference[oaicite:9]{index=9}
- ACE inhibitors: Co-administration may precipitate hypotension due to volume expansion.
- Colloid co-administration: Combining with HES or dextrans may cause excessive volume—monitor carefully. :contentReference[oaicite:10]{index=10}
- Fluid shifts: May dilute electrolytes—monitor sodium, potassium, calcium. :contentReference[oaicite:11]{index=11}
Compatibility: May be administered with blood components or crystalloid solutions but must not be diluted with sterile water or mixed with amino acid or alcohol-containing solutions. :contentReference[oaicite:12]{index=12}
Dosage of ALBUMIN NOVONORDISK 5%
Dosage depends on clinical context, weight, and response. Total daily dose shouldn’t exceed 2 g/kg.
- Hypovolemia / Shock:
- Adults: 250–500 mL (~12.5–25 g albumin) initially; may repeat after 15–30 min if needed. :contentReference[oaicite:13]{index=13}
- Children: 4.5–6.8 mL/kg (≈0.2–0.3 g/kg), adjust by response. :contentReference[oaicite:14]{index=14}
- Hypoalbuminemia / Edema:
- Adults: 250–500 mL (12.5–25 g) per day. :contentReference[oaicite:15]{index=15}
- Post-Paracentesis (Cirrhosis):
- 8 g albumin per 1 000 mL ascites removed—250 mL per 8 g. :contentReference[oaicite:16]{index=16}
- Burns (after 24 h): 250–500 mL (12.5–25 g); adjust to maintain serum proteins. :contentReference[oaicite:17]{index=17}
Dosing must be guided by hemodynamic endpoints—blood pressure, urine output, central venous pressure—not just lab values. :contentReference[oaicite:18]{index=18}
Possible side effects of ALBUMIN NOVONORDISK 5%
Generally safe, but volume loading and infusion reactions may occur.
- Common: Fever, chills, rigors, flushing, nausea, headache, tachycardia, hypotension. Often mild and infusion-rate related. :contentReference[oaicite:19]{index=19}
- Volume overload: Edema, pulmonary congestion—especially in heart or renal failure. :contentReference[oaicite:20]{index=20}
- Electrolyte dilution: Possible hyponatremia, hypokalemia—monitor labs. :contentReference[oaicite:21]{index=21}
- Allergic/anaphylactic: Rare—urticaria, bronchospasm, hypotension. Stop infusion and treat if occurs. :contentReference[oaicite:22]{index=22}
- Hemodilution anemia: May worsen existing anemia—correct if needed. :contentReference[oaicite:23]{index=23}
Monitor vital signs, respiratory, and renal status. Slow or stop infusion at first sign of serious reaction.
ALBUMIN NOVONORDISK 5% Contraindications ALBUMIN NOVONORDISK 5%
- Absolute:
- Hypersensitivity to albumin or excipients. :contentReference[oaicite:24]{index=24}
- Severe anemia—risk of further dilution. :contentReference[oaicite:25]{index=25}
- Decompensated heart failure, pulmonary edema. :contentReference[oaicite:26]{index=26}
- Use with caution:
- Renal impairment
- Hypertension
- Bleeding disorders/esophageal varices
- Concurrent ACE inhibitor
- Pregnancy/lactation (Category C)—only if essential. :contentReference[oaicite:27]{index=27}
- Pediatric (including neonates)—must be guided by specialist. :contentReference[oaicite:28]{index=28}
Evaluate cardiovascular and renal status before administration. Monitor closely throughout therapy.
Storage of ALBUMIN NOVONORDISK 5%
- Temperature: Store at 2–25 °C (36–77 °F); do not freeze. :contentReference[oaicite:29]{index=29}
- Protection from light: Keep in original carton.
- Handling:
- Avoid shaking.
- Inspect prior to use—discard cloudy or particulate-containing vials.
- Once opened or accessed, use immediately—discard any remainder. :contentReference[oaicite:30]{index=30}
- Expiry: Check and do not use after date on vial.
- Disposal: Follow biomedical waste guidelines; do not flush or discard in household waste.
ALBUMIN NOVONORDISK 5% features an exceptional active ingredient renowned for its potent effects, comprising Albumin (human). This powerful formulation provides a superior solution for addressing diverse health concerns. With 50mg/ml concentration and an easily manageable Infusion, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALBUMIN NOVONORDISK 5% .
Welcome to Dwaey, specifically on ALBUMIN NOVONORDISK 5% page.
This medicine contains an important and useful components, as it consists of Albumin (human).
ALBUMIN NOVONORDISK 5% is available in the market in concentration 50mg/ml and in the form of Infusion.
NOVO NORDISK A/S is the producer of ALBUMIN NOVONORDISK 5% and it is imported from DENMARK,
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Frequently Asked Questions
ALBUMIN NOVONORDISK 5% should be stored according to the instructions provided by NOVO NORDISK A/S.
In general, it is recommended to store ALBUMIN NOVONORDISK 5% in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALBUMIN NOVONORDISK 5% may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALBUMIN NOVONORDISK 5% for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALBUMIN NOVONORDISK 5%. Some medications, including
ALBUMIN NOVONORDISK 5%, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALBUMIN NOVONORDISK 5%, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALBUMIN NOVONORDISK 5% without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALBUMIN NOVONORDISK 5% if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALBUMIN NOVONORDISK 5% during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 50mg/ml,
and the specific recommendations of NOVO NORDISK A/S.
The effects of ALBUMIN NOVONORDISK 5% on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 50mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALBUMIN NOVONORDISK 5% with or without food may vary depending on the medication
and the recommendations of NOVO NORDISK A/S. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALBUMIN NOVONORDISK 5% in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion, and the recommendations of NOVO NORDISK A/S. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALBUMIN NOVONORDISK 5% in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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