What is ALBUMIN NOVONORDISK 20%
ALBUMIN NOVONORDISK 20% is a sterile, hyperoncotic (20% w/v) solution of human albumin derived from pooled human plasma, provided in a 100 mL single-use vial for intravenous infusion.
- Pharmaceutical Class: Colloid volume expander (plasma protein solution).
- Primary Indications:
- Hypovolemia or circulatory shock from trauma, surgery, or hemorrhage.
- Hypoalbuminemia—when low plasma albumin (<2.5 g/dL) coexists with edema or volume depletion.
- After large-volume paracentesis in cirrhotic patients to prevent circulatory dysfunction.
- Burn patients (after initial crystalloid resuscitation).
- ARDS, nephrotic syndrome, cardiopulmonary bypass priming fluids.
- Ovarian hyperstimulation syndrome (OHSS).
- Hemolytic disease of the newborn (HDN) to bind bilirubin.
- Characteristics: Passage through viral inactivation via pasteurization; sterile, non-pyrogenic; single-use.
- Administration Setting: Inpatient use under strict medical monitoring.
Its hyperoncotic nature allows efficient restoration of intravascular volume and supports maintenance of cardiac output and tissue perfusion.
How to use ALBUMIN NOVONORDISK 20%
ALBUMIN NOVONORDISK 20% should be administered intravenously using aseptic technique. Inspect the vial before use—solution must be clear to slightly opalescent, without particulates or discoloration. Warm to room temperature if infusing a large volume.
- Preparation:
- Do not freeze.
- Use supplied infusion set; do not mix with other IV fluids unless compatibility verified.
- Infusion:
- Typical infusion rate: 1–2 mL/min (≈1–2 g albumin/min) :contentReference[oaicite:1]{index=1}.
- In emergency hypovolemia, may start faster but with close monitoring.
- Monitoring Parameters:
- Vital signs—BP, HR, respiratory rate, temperature
- Fluid balance (input/output)
- Urine output and central venous pressure where applicable
- Signs of fluid overload—edema, difficulty breathing
- Post-infusion: Discard any unused portion; single-use only.
Dosage adjustments and infusion rates should be individualized based on clinical response, lab results, and patient’s cardiovascular reserve.
Mode of Action ALBUMIN NOVONORDISK 20%
Albumin, a major plasma protein synthesized in the liver, is crucial for maintaining intravascular oncotic pressure and serves as a carrier molecule. Exogenously administered 20% albumin is hyperoncotic, pulling fluid from interstitial and third spaces into blood vessels.
- Oncotic Pressure: Raises plasma colloid osmotic pressure, effectively drawing extracellular fluids into circulation.
- Volume Expansion: Each mL infused may mobilize 2–4 mL of fluid, enhancing preload and improving stroke volume.
- Carrier Function: Binds endogenously produced molecules (bilirubin, fatty acids, hormones) and concurrently administered drugs; helps in detoxifying substances.
- Buffering Capacity: Serves as a weak acid/base buffer, helping stabilize pH.
Albumin provides both therapeutic efficacy in volume resuscitation and physiologic support via molecular transport mechanisms. Its colloid nature is particularly helpful when fluid restriction is needed to avoid edema. :contentReference[oaicite:2]{index=2}
ALBUMIN NOVONORDISK 20% Interactions ALBUMIN NOVONORDISK 20%
As a plasma protein, albumin has minimal direct pharmacologic interactions. However, consider the following:
- Displacement Effects: Large albumin infusions may displace certain drugs (e.g., warfarin, phenytoin, diazepam), increasing free drug fractions :contentReference[oaicite:3]{index=3}.
- ACE‑inhibitors: Combined use may cause hypotension—monitor blood pressure.
- Other Colloids: Concurrent infusion with synthetic colloids (starches, dextrans) may increase intravascular volume—monitor carefully.
- Electrolyte Shifts: Rapid volume expansion can dilute sodium, potassium, calcium—monitor serum electrolytes.
Also note incompatibilities: Do not dilute albumin with sterile water (risk of hemolysis); avoid mixing with protein hydrolysates or alcohol-based solutions. :contentReference[oaicite:4]{index=4}
Dosage of ALBUMIN NOVONORDISK 20%
Dosing is individualized according to patient weight, clinical condition, and response. Daily doses should not exceed 2 g/kg.
- Hypovolemia/Shock:
- Adults: 25 g IV initially (≈125 mL); repeat in 15–30 min if needed :contentReference[oaicite:5]{index=5}.
- Children: 0.5–1 g/kg, may repeat :contentReference[oaicite:6]{index=6}.
- Hypoalbuminemia:
- Adults: 50–75 g/day :contentReference[oaicite:7]{index=7}.
- Children: ~25 g/day :contentReference[oaicite:8]{index=8}.
- Large-Volume Paracentesis:
- 8 g per 1 000 mL ascitic fluid removed :contentReference[oaicite:9]{index=9}.
- ARDS: 25 g IV over 30 min, repeat q8h for up to 3 days :contentReference[oaicite:10]{index=10}.
- OHSS: 50–100 g over 4 h, may repeat q4–12h :contentReference[oaicite:11]{index=11}.
- HDN: 1 g/kg before/during exchange transfusion :contentReference[oaicite:12]{index=12}.
Always base dosing adjustments on clinical parameters—vital signs, urine output—not just plasma albumin levels. :contentReference[oaicite:13]{index=13}
Possible side effects of ALBUMIN NOVONORDISK 20%
Human albumin is generally well tolerated, but infusion may cause mild to serious reactions:
- Mild infusional reactions: Fever, chills, flushing, nausea, vomiting, headache; typically temporary and rate-related :contentReference[oaicite:14]{index=14}.
- Cardiovascular effects: Hypotension (especially if infused too quickly or combined with ACE inhibitors), tachycardia :contentReference[oaicite:15]{index=15}.
- Volume overload: Edema, pulmonary congestion, particularly in heart or renal failure patients :contentReference[oaicite:16]{index=16}.
- Allergic/anaphylaxis (rare): Urticaria, bronchospasm, hypotension, potential anaphylactic shock :contentReference[oaicite:17]{index=17}.
- Hemodilution: May dilute hematocrit—monitor and replace cells if needed :contentReference[oaicite:18]{index=18}.
Monitor hemodynamics and labs during infusion. Slow or stop infusion at first sign of adverse reaction.
ALBUMIN NOVONORDISK 20% Contraindications ALBUMIN NOVONORDISK 20%
Certain conditions require absolute or relative contraindications:
- Absolute:
- Known hypersensitivity to albumin or formulation components.
- Severe anemia (risk of further hematocrit dilution) :contentReference[oaicite:19]{index=19}.
- Decompensated heart failure or pulmonary edema—excess volume may worsen condition :contentReference[oaicite:20]{index=20}.
- Relative (use with caution):
- Renal impairment (risk of volume overload)
- Uncontrolled hypertension
- Bleeding disorders
- Dehydration without true hypovolemia—crystalloids first :contentReference[oaicite:21]{index=21}.
- Pregnancy/lactation—use only if clearly needed :contentReference[oaicite:22]{index=22}.
- Pediatric patients—careful dosing and monitoring :contentReference[oaicite:23]{index=23}.
Evaluate contraindications before therapy; monitor high-risk patients closely throughout infusion.
Storage of ALBUMIN NOVONORDISK 20%
Correct storage is vital for maintaining albumin solution integrity and safety:
- Temperature: Store between 2–25 °C (36–77 °F); do not freeze or expose to high heat.
- Light Protection: Keep in original carton to shield from direct light.
- Physical Stability: Avoid shaking to prevent protein denaturation and foaming.
- Before Use:
- Visually inspect for turbidity or particulates—discard abnormal vials.
- If large volumes are needed, allow warming to room temperature before infusion.
- Post-Access: Use immediately; discard any remaining solution after opening vial (single-use).
- Disposal: Dispose in compliance with biomedical waste regulations. Do not flush or discard in non-medical trash.
Ensure secure, child-proof storage in healthcare facilities or clinical settings.
ALBUMIN NOVONORDISK 20% features an exceptional active ingredient renowned for its potent effects, comprising Albumin (human). This powerful formulation provides a superior solution for addressing diverse health concerns. With 200mg/ml concentration and an easily manageable Infusion, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALBUMIN NOVONORDISK 20% .
Welcome to Dwaey, specifically on ALBUMIN NOVONORDISK 20% page.
This medicine contains an important and useful components, as it consists of Albumin (human).
ALBUMIN NOVONORDISK 20% is available in the market in concentration 200mg/ml and in the form of Infusion.
NOVO NORDISK A/S is the producer of ALBUMIN NOVONORDISK 20% and it is imported from DENMARK,
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Frequently Asked Questions
ALBUMIN NOVONORDISK 20% should be stored according to the instructions provided by NOVO NORDISK A/S.
In general, it is recommended to store ALBUMIN NOVONORDISK 20% in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALBUMIN NOVONORDISK 20% may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALBUMIN NOVONORDISK 20% for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALBUMIN NOVONORDISK 20%. Some medications, including
ALBUMIN NOVONORDISK 20%, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALBUMIN NOVONORDISK 20%, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALBUMIN NOVONORDISK 20% without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALBUMIN NOVONORDISK 20% if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALBUMIN NOVONORDISK 20% during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 200mg/ml,
and the specific recommendations of NOVO NORDISK A/S.
The effects of ALBUMIN NOVONORDISK 20% on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 200mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALBUMIN NOVONORDISK 20% with or without food may vary depending on the medication
and the recommendations of NOVO NORDISK A/S. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALBUMIN NOVONORDISK 20% in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion, and the recommendations of NOVO NORDISK A/S. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALBUMIN NOVONORDISK 20% in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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