ALBUMIN NOVONORDISK 20% Infusion

What is ALBUMIN NOVONORDISK 20%

ALBUMIN NOVONORDISK 20% is a sterile, hyperoncotic plasma expander containing human albumin at 200 g/L (20 %) in a 50 mL bottle. Extracted from pooled donor plasma, it undergoes rigorous viral inactivation (e.g., pasteurization) to ensure safety and sterility.

• Classification: Human albumin solution; colloid volume expander.
• Indications:
  • Hypovolemia and hypovolemic shock
  • Hypoalbuminemia in critically ill or bleeding patients
  • Prevention of circulatory dysfunction post-paracentesis in cirrhosis
  • Ovarian hyperstimulation syndrome (OHSS)
  • ARDS as adjunct with diuretics
  • Acute nephrosis unresponsive to diuretics
  • Neonatal hyperbilirubinemia in exchange transfusion
• Packaging: Single-dose sterile 50 mL bottle with albumin and infusion set.

This product is reserved for clinical settings, administered under close monitoring by trained healthcare professionals.

How to use ALBUMIN NOVONORDISK 20%

Prior to administration, inspect the bottle. The solution should be clear to slightly opalescent; discard if cloudy or particulate is present. Allow it to reach room temperature before infusion.

• Route: Intravenous (IV) only, using aseptic technique.
• Infusion setup: Connect the provided infusion set. Do not dilute with water or mix with other IV fluids.
• Infusion rate:
  • Typical: up to 1–2 mL/min (≈1g albumin per minute).
  • If large volumes (>1500 mL) are needed, warm to room temperature.
• Monitoring: Track vitals (BP, HR), fluid status, and signs of overload. Adjust rate accordingly.
• Post-infusion: Discard unused portion and maintain sterility.

Repeated doses may be administered based on clinical response. Always tailor infusion speed and volume to the patient’s cardiovascular status to avoid complications. :contentReference[oaicite:1]{index=1}

Mode of Action ALBUMIN NOVONORDISK 20%

Human albumin plays multiple physiological roles, with the 20 % solution offering potent volume-expanding benefits:

• Oncotic pressure: High albumin concentration draws fluid from interstitial to intravascular compartments.
• Volume expansion: Each mL infused can mobilize 2–4 mL plasma volume—quickly restoring circulating volume in shock.
• Molecular transport: Binds and carries hormones, fatty acids, drugs (e.g., warfarin), and bilirubin.
• Buffering: Helps maintain plasma pH and electrolyte balance.

Overall, albumin improves hemodynamics, tissue perfusion, and supports fluid balance in critical conditions. Its colloid osmotic effect is especially useful when fluid restriction is necessary. :contentReference[oaicite:2]{index=2}

ALBUMIN NOVONORDISK 20% Interactions ALBUMIN NOVONORDISK 20%

Albumin infusions have a low risk of pharmacokinetic interactions, but certain considerations apply:

• Displacement of bound drugs: High-dose albumin can release drugs like warfarin or phenytoin, increasing free drug levels.
• ACE inhibitors: Combining with albumin may trigger hypotension—monitor blood pressure closely.
• Other colloids: Concomitant use with synthetic colloids may lead to hypovolemia or overload—avoid without monitoring.
• Electrolyte shifts: Volume shifts can dilute electrolytes—monitor sodium, potassium, calcium.

Interactions are mild experimentally; most risk comes from physiological effects of volume changes. Maintain close observation of vitals and drug levels when using with anticoagulants, diuretics, or in renal/cardiac impairment. :contentReference[oaicite:3]{index=3}

Dosage of ALBUMIN NOVONORDISK 20%

Dosing is individualized by weight, condition severity, and response.

• Hypovolemia: Adults: 25 g (~125 mL). Can repeat after 15–30 min if needed. Pediatric: 0.5–1 g/kg (≈25–50 mL/kg). :contentReference[oaicite:4]{index=4}
• Hypoalbuminemia: Adults: 50–75 g/day. Pediatric: ~25 g/day. :contentReference[oaicite:5]{index=5}
• Paracentesis: 8 g per 1000 mL ascites removed. :contentReference[oaicite:6]{index=6}
• ARDS: 25 g over 30 min, repeat every 8 hrs for 3 days. :contentReference[oaicite:7]{index=7}
• OHSS: 50–100 g over 4 hrs; repeat every 4–12 hrs as needed. :contentReference[oaicite:8]{index=8}
• Neonatal hyperbilirubinemia: 1 g/kg before/during exchange transfusion. :contentReference[oaicite:9]{index=9}

Do not exceed 2 g/kg/day. Monitor hemodynamics and labs during therapy. :contentReference[oaicite:10]{index=10}

Possible side effects of ALBUMIN NOVONORDISK 20%

While generally safe, albumin infusions can cause side effects ranging from common infusion-related symptoms to rare serious events:

• Mild reactions: Fever, chills, flushing, nausea. Often resolve with slower infusion. :contentReference[oaicite:11]{index=11}
• Hypotension: May result from rapid infusion or ACE inhibitor interaction—infuse slowly. :contentReference[oaicite:12]{index=12}
• Volume overload: Watch for pulmonary edema or heart failure in predisposed patients. :contentReference[oaicite:13]{index=13}
• Allergic/anaphylaxis: Urticaria, bronchospasm, rarely anaphylactic shock—infusion should be stopped immediately. :contentReference[oaicite:14]{index=14}
• Hemo-dilution: May dilute hematocrit—supplement blood if hemorrhage. :contentReference[oaicite:15]{index=15}

Monitor vitals and labs, especially in at-risk patients. Slow or stop infusion upon serious reactions. :contentReference[oaicite:16]{index=16}

ALBUMIN NOVONORDISK 20% Contraindications ALBUMIN NOVONORDISK 20%

Use is contraindicated or should be used with caution in the following scenarios:

• Absolute:
  • Known hypersensitivity to human albumin or any excipients
  • Severe anemia (can worsen oxygen delivery)
  • Decompensated heart failure or pulmonary edema (risk of volume overload) :contentReference[oaicite:17]{index=17}
• Relative/caution:
  • Renal impairment (risk of fluid retention)
  • Hypertension
  • Bleeding disorders
  • Dehydration without hypovolemia
  • Pregnant or lactating women (use only if benefit outweighs risk) :contentReference[oaicite:18]{index=18}
  • Pediatrics needs special dosing and monitoring :contentReference[oaicite:19]{index=19}

Use only after careful clinical evaluation. Continuous monitoring is essential during administration.

Storage of ALBUMIN NOVONORDISK 20%

Storage Instructions:

• Keep between 2–25 °C (36–77 °F); do not freeze. :contentReference[oaicite:20]{index=20}
• Store in original container, protected from light.
• Avoid shaking to prevent protein denaturation or foaming.

Handling before use:

• Inspect visually for cloudiness or particulates; discard if abnormal.
• Do not dilute with non-approved solutions.
• Once opened, use immediately and discard unused portion. :contentReference[oaicite:21]{index=21}

Disposal: Follow biohazard/local regulations. Do not flush or discard with household waste.