What is AGOUT 80mg
AGOUT 80mg is a prescription medication containing Febuxostat, a non-purine selective xanthine oxidase inhibitor used to manage chronic hyperuricemia in adults with gout. Gout is a type of arthritis that occurs when uric acid builds up in the joints, leading to painful inflammation. AGOUT is indicated particularly for patients who are intolerant to or inadequately treated by allopurinol.
- Generic Name: Febuxostat
- Form: Film-coated Tablets
- Strength: 80mg
- Pack Size: 30 tablets (15s Blister x 2)
Unlike traditional treatments like allopurinol, AGOUT (Febuxostat) is not structurally related to purines and is more selective, potentially leading to better control of serum uric acid levels without significantly affecting other enzymes.
This medication is often used as long-term therapy and is part of a comprehensive management plan that includes dietary changes, hydration, and lifestyle modifications.
How to use AGOUT 80mg
Proper administration of AGOUT is essential for effective uric acid control and to minimize the risk of gout flare-ups. Always follow your healthcare provider’s instructions precisely when using this medication.
- Administration: Take AGOUT 80mg orally with or without food.
- Timing: Preferably at the same time each day to maintain consistent blood levels.
- Swallow Whole: Do not crush or chew the tablets. Take them with water.
Key usage recommendations:
- Initial Therapy: Gout flares may occur when starting AGOUT, due to mobilization of urate crystals. Physicians often prescribe anti-inflammatory prophylaxis (e.g., NSAIDs or colchicine) during the first 6 months.
- Missed Dose: If you forget to take a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose—do not double up.
- Hydration: Adequate fluid intake is advised to help the kidneys excrete uric acid.
Continued use is critical, even if you feel well, as this medication is meant to prevent future gout attacks rather than treat acute pain.
Mode of Action AGOUT 80mg
Febuxostat, the active ingredient in AGOUT 80mg, works by inhibiting the enzyme xanthine oxidase, which plays a central role in the production of uric acid.
- Xanthine oxidase: An enzyme responsible for converting hypoxanthine to xanthine, and then xanthine to uric acid.
- Febuxostat’s Action: Binds selectively and reversibly to xanthine oxidase, reducing the conversion process and therefore lowering serum uric acid levels.
Pharmacological effects:
- Reduces Uric Acid: Maintains serum uric acid levels below 6 mg/dL, reducing the risk of gout flares and urate crystal deposition.
- Non-purine Structure: Offers a safer alternative to allopurinol, especially for those with mild-to-moderate renal impairment or allopurinol hypersensitivity.
- Rapid Onset: Begins lowering uric acid levels within days of initiation, with steady-state reached in about 2 weeks.
This mechanism not only helps prevent new gout attacks but also supports the resolution of tophi and improves joint health over time.
AGOUT 80mg Interactions AGOUT 80mg
AGOUT (Febuxostat) may interact with various medications, altering their effects or increasing the risk of side effects. Careful review of your full medication list with your doctor is essential before starting therapy.
- Azathioprine & Mercaptopurine: Contraindicated. Co-administration can lead to severe toxicity, including bone marrow suppression. Avoid using together.
- Theophylline: Febuxostat may increase plasma concentrations. Monitor for theophylline toxicity (nausea, restlessness, tremors).
- Warfarin: Although not clinically significant in trials, INR should be monitored during initiation or dose adjustment.
- Antacids (Aluminum hydroxide, Magnesium hydroxide): May slightly reduce Febuxostat absorption. Administer at different times if needed.
Herbal and supplement cautions:
- Vitamin C: High doses may increase uric acid excretion, potentially masking efficacy evaluation.
- Herbal diuretics: Such as dandelion or nettle, may increase uric acid excretion and compound effects.
Always inform your healthcare provider of all drugs, supplements, or herbal remedies you are using before starting AGOUT.
Dosage of AGOUT 80mg
The dosage of AGOUT (Febuxostat) should be tailored to the individual patient based on their uric acid levels and clinical response.
- Initial Dose: 40 mg once daily
- Maintenance Dose: May increase to 80 mg once daily if serum uric acid levels remain above 6 mg/dL after 2-4 weeks
Special populations:
- Renal Impairment: No dose adjustment needed in mild-to-moderate renal dysfunction.
- Hepatic Impairment: Caution advised in moderate hepatic impairment. Avoid in severe cases.
- Elderly: No specific dose adjustments, but monitor for adverse effects.
Tips for effective dosing:
- Monitor serum uric acid levels after 2 weeks of therapy and adjust accordingly.
- Use prophylactic anti-inflammatory therapy (e.g., colchicine or NSAIDs) during the first 6 months to prevent flare-ups.
- Do not stop the medication during a gout attack. Continue therapy unless advised otherwise by a physician.
Always use the lowest effective dose to achieve target uric acid levels and reduce side effects.
Possible side effects of AGOUT 80mg
While AGOUT is generally well tolerated, it may cause side effects in some individuals. These can range from mild to severe.
- Common Side Effects:
- Gout flares (especially during initiation)
- Liver function abnormalities (elevated ALT/AST)
- Nausea
- Headache
- Joint pain
- Uncommon/Rare Side Effects:
- Skin rash or hypersensitivity reactions
- Cardiovascular events (angina, myocardial infarction)
- Diarrhea
- Fatigue or drowsiness
- Serious Adverse Reactions:
- Severe allergic reactions (Stevens-Johnson syndrome)
- Agranulocytosis, thrombocytopenia (rare)
- Increased risk of cardiovascular mortality in some patients (monitor closely)
If any unusual symptoms occur, patients should seek medical attention immediately, particularly for skin reactions, chest pain, or signs of liver dysfunction.
AGOUT 80mg Contraindications AGOUT 80mg
AGOUT (Febuxostat) is not suitable for everyone. Certain pre-existing medical conditions or drug interactions can make its use dangerous.
- Hypersensitivity: Contraindicated in patients with known allergy to Febuxostat or any excipients.
- Use with Azathioprine or Mercaptopurine: Strictly contraindicated due to life-threatening myelotoxicity risk.
- Severe Hepatic Impairment: Not recommended due to lack of safety data.
- Patients with Ischemic Heart Disease or Congestive Heart Failure: Caution is advised due to observed cardiovascular risks in some studies.
Conditions that warrant caution (relative contraindications):
- Renal impairment (monitor closely)
- Liver dysfunction (adjustment or monitoring needed)
- History of cardiovascular events
AGOUT should not be used to treat asymptomatic hyperuricemia. Use is limited to patients with a clear clinical indication, such as recurrent gout flares or tophaceous gout.
Storage of AGOUT 80mg
Proper storage ensures the medication remains effective and safe for use throughout its shelf life.
- Temperature: Store below 30°C (86°F). Do not freeze.
- Humidity: Keep in a dry place. Protect from moisture and humidity.
- Packaging: Keep the tablets in their original blister pack until use to protect them from light and air.
Additional precautions:
- Keep Out of Reach: Store away from children and pets.
- Avoid Bathroom Storage: Humid environments may degrade the tablet.
- Check Expiry: Do not use after the expiration date printed on the pack.
Discard unused medication properly in accordance with local guidelines—do not flush down the toilet or throw in household garbage.
AGOUT 80mg features an exceptional active ingredient renowned for its potent effects, comprising Febuxostat. This powerful formulation provides a superior solution for addressing diverse health concerns. With 80mg/Tablet concentration and an easily manageable Tablets/Film-coated, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about AGOUT 80mg .
Welcome to Dwaey, specifically on AGOUT 80mg page.
This medicine contains an important and useful components, as it consists of Febuxostat.
AGOUT 80mg is available in the market in concentration 80mg/Tablet and in the form of Tablets/Film-coated.
SPIMACO (AL QASSIM PHARMACEUTICAL PLANT) is the producer of AGOUT 80mg and it is imported from SAUDI ARABIA,
The most popular alternatives of AGOUT 80mg are listed downward .
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SPIMACO (AL QASSIM PHARMACEUTICAL PLANT)
Frequently Asked Questions
AGOUT 80mg should be stored according to the instructions provided by SPIMACO (AL QASSIM PHARMACEUTICAL PLANT).
In general, it is recommended to store AGOUT 80mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with AGOUT 80mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking AGOUT 80mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking AGOUT 80mg . Some medications, including
AGOUT 80mg , may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of AGOUT 80mg , take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking AGOUT 80mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking AGOUT 80mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of AGOUT 80mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 80mg/Tablet,
and the specific recommendations of SPIMACO (AL QASSIM PHARMACEUTICAL PLANT).
The effects of AGOUT 80mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 80mg/Tablet, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking AGOUT 80mg with or without food may vary depending on the medication
and the recommendations of SPIMACO (AL QASSIM PHARMACEUTICAL PLANT). Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of AGOUT 80mg in children or elderly individuals may depend on various factors, including
the specific medication, type Tablets/Film-coated, and the recommendations of SPIMACO (AL QASSIM PHARMACEUTICAL PLANT). Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of AGOUT 80mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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