AFRIN 0.05% Nasal Drops

What is AFRIN 0.05%

AFRIN 0.05% Nasal Drops is a decongestant medication used primarily for the relief of nasal congestion associated with the common cold, sinusitis, hay fever, and other upper respiratory allergies. It contains the active ingredient Oxymetazoline Hydrochloride, a potent topical vasoconstrictor belonging to the imidazoline class of sympathomimetic agents.

• Form: Nasal Drops
• Concentration: 0.05% Oxymetazoline HCl
• Pack Size: 30 ml
• Indication: Temporary relief of nasal and sinus congestion due to colds, allergies, or sinusitis.
• Onset of Action: Within minutes of application
• Duration: Provides relief for up to 12 hours

This product is intended for intranasal use only and should not be ingested or used in the eyes.

How to use AFRIN 0.05%

Correct usage of AFRIN 0.05% Nasal Drops is crucial for effective relief and to prevent potential side effects such as rebound congestion.

• Step 1 – Blow your nose: Gently clear your nostrils before using the drops to ensure better absorption of the medication.
• Step 2 – Tilt your head back: Lie down or tilt your head back slightly while sitting or standing.
• Step 3 – Apply the drops: Using the dropper, instill 2 to 3 drops into each nostril. Avoid touching the dropper tip to your nose or any surface to prevent contamination.
• Step 4 – Remain in position: Keep your head tilted back for a few minutes to allow the medication to spread inside the nasal passages.

Important Usage Tips:

• Use every 10–12 hours as needed. Do not exceed 2 doses in 24 hours.
• Do not use for more than 3 consecutive days to avoid rebound nasal congestion.
• Wash hands before and after use.
• Consult a doctor if symptoms persist or worsen.

Mode of Action AFRIN 0.05%

Oxymetazoline Hydrochloride, the active ingredient in AFRIN, is a selective alpha-adrenergic agonist. Its primary action is to constrict the blood vessels in the nasal mucosa, thereby reducing swelling and congestion.

• Vasoconstriction: It stimulates alpha-1 adrenergic receptors in the arterioles of the nasal mucosa, causing vasoconstriction.
• Reduction in Edema: The reduced blood flow decreases mucosal edema, leading to improved airflow and breathing.
• Local Effect: Acts locally on the nasal mucosa without significant systemic absorption when used properly.
• Onset & Duration: Begins working within 5–10 minutes and lasts up to 12 hours.

This mechanism provides quick and sustained relief from nasal congestion without affecting the central nervous system.

AFRIN 0.05% Interactions AFRIN 0.05%

Although AFRIN is a topical nasal agent with limited systemic absorption, interactions with certain medications can still occur, especially in susceptible individuals.

• Monoamine Oxidase Inhibitors (MAOIs): Concomitant use may lead to hypertensive crisis. Avoid using AFRIN within 14 days of stopping MAOIs.
• Tricyclic Antidepressants: May enhance the sympathomimetic effects of oxymetazoline, leading to increased blood pressure or arrhythmias.
• Beta-blockers: May reduce the efficacy of AFRIN and increase the risk of systemic side effects such as bradycardia.
• Other Decongestants: Using multiple topical or systemic decongestants can amplify vasoconstriction and lead to elevated blood pressure or rebound congestion.

General Advice:

• Inform your healthcare provider about all medications you are currently using, including over-the-counter and herbal supplements.
• Be cautious if you are on medications for hypertension, depression, or heart disease.

Dosage of AFRIN 0.05%

Proper dosing is essential to maximize therapeutic benefit and minimize the risk of side effects or rebound congestion.

• Adults and Children ≥ 6 Years: 2 to 3 drops in each nostril every 10–12 hours as needed. Do not exceed 2 doses in 24 hours.
• Children Under 6 Years: Use only under medical supervision. Pediatric-specific formulations are preferred.
• Maximum Duration of Use: Do not use continuously for more than 3 consecutive days.

Dosage Tips:

• Shake the bottle gently before use.
• Do not exceed the recommended dose.
• Consult a physician if symptoms persist beyond 3 days or worsen.

Possible side effects of AFRIN 0.05%

While generally well tolerated, AFRIN may cause local and systemic side effects, especially if used improperly or for extended periods.

• Common Side Effects:
  • Transient nasal burning or stinging
  • Dryness of the nasal mucosa
  • Sneezing
• Less Common Side Effects:
  • Headache
  • Nausea
  • Insomnia
• Serious Side Effects:
  • Rebound congestion (rhinitis medicamentosa) after prolonged use
  • Increased blood pressure
  • Palpitations or irregular heartbeat

Discontinue use and seek medical attention if severe dizziness, breathing difficulty, or swelling of the face/tongue/throat occurs.

AFRIN 0.05% Contraindications AFRIN 0.05%

AFRIN should not be used in certain medical conditions due to the risk of complications from vasoconstriction or hypersensitivity.

• Known Hypersensitivity: Contraindicated in individuals allergic to Oxymetazoline or any component of the formulation.
• Narrow-Angle Glaucoma: May worsen intraocular pressure.
• Recent Nasal Surgery: Use may interfere with healing or cause irritation.
• Severe Hypertension or Heart Disease: May exacerbate cardiovascular symptoms due to vasoconstriction.
• Use with MAOIs: Risk of hypertensive crisis; avoid concurrent use or within 14 days of MAOI discontinuation.

Always consult with a healthcare provider before starting AFRIN if you have chronic health conditions.

Storage of AFRIN 0.05%

Proper storage helps maintain the effectiveness and safety of the product throughout its shelf life.

• Storage Temperature: Store at room temperature between 15°C to 25°C (59°F to 77°F).
• Keep away from heat and sunlight: Avoid direct exposure to heat sources or freezing temperatures.
• Secure Lid Tightly: Always close the cap properly after use to prevent contamination and evaporation.
• Keep Out of Reach of Children: Especially important due to the risk of serious side effects if ingested.
• Do Not Use After Expiry: Check the label for the expiration date and discard unused product appropriately.

Do not transfer the content to another container. Use only as packaged by the manufacturer to ensure sterility.