AERIALLERG 5mg Tablet/Film coated

What is AERIALLERG 5mg

AERIALLERG 5mg is a film-coated tablet containing Desloratadine as the active ingredient, a second-generation antihistamine used to relieve symptoms associated with allergic conditions. It is a well-established medication prescribed primarily for the treatment of allergic rhinitis and chronic idiopathic urticaria.

• Active Ingredient: Desloratadine 5 mg per tablet.
• Formulation: Film-coated tablet designed for oral administration, improving taste masking and ease of swallowing.
• Indications: Effective in managing symptoms such as sneezing, runny nose, nasal congestion, itchy and watery eyes, and skin itching or hives.
• Non-Sedating: Unlike first-generation antihistamines, AERIALLERG 5mg has minimal sedative effects due to limited penetration across the blood-brain barrier.
• Usage Population: Suitable for adults and children over 12 years, providing once-daily dosing convenience.
• Benefits: Long-acting with a once-daily dose, providing consistent relief over 24 hours and improving patient compliance.

In summary, AERIALLERG 5mg tablets are an effective and safe choice for managing allergic symptoms with minimal side effects.

How to use AERIALLERG 5mg

Proper administration of AERIALLERG 5mg tablets ensures maximum efficacy and safety.

• Dosage: Typically, one 5 mg tablet once daily is recommended for adults and adolescents aged 12 years and above.
• Administration: Take the tablet orally with a glass of water. It can be taken with or without food.
• Consistency: Take the medication at the same time every day to maintain steady blood levels and symptom control.
• Duration: Use as prescribed by a healthcare provider. For seasonal allergies, treatment is often continued throughout the allergy season; for chronic urticaria, treatment duration varies based on symptom control.
• Missed Dose: If a dose is missed, take it as soon as remembered unless it is close to the next scheduled dose. Do not double doses to compensate.
• Precautions: Avoid alcohol and other central nervous system depressants unless approved by your doctor, as they might increase drowsiness in sensitive individuals.
• Consultation: Inform your healthcare provider if symptoms persist or worsen despite treatment or if you experience any unusual effects.

Following these instructions helps ensure safe and effective treatment with AERIALLERG 5mg tablets.

Mode of Action AERIALLERG 5mg

AERIALLERG 5mg exerts its therapeutic effect primarily through selective antagonism of peripheral histamine H₁ receptors.

• Histamine Role: During allergic reactions, mast cells release histamine, which binds to H₁ receptors causing symptoms like vasodilation, increased vascular permeability, itching, and bronchoconstriction.
• Selective H₁ Blocker: Desloratadine binds selectively to H₁ receptors, blocking histamine’s effects and thus preventing or reducing allergy symptoms.
• Minimal CNS Penetration: Unlike first-generation antihistamines, desloratadine minimally crosses the blood-brain barrier, resulting in negligible sedation or cognitive impairment.
• Anti-Inflammatory Effects: Desloratadine may inhibit the release of other inflammatory mediators and reduce eosinophil recruitment, contributing to decreased allergic inflammation.
• Pharmacokinetics: Rapid onset of action within 1-3 hours and a long half-life enables once-daily dosing with sustained symptom control over 24 hours.

This mode of action makes AERIALLERG 5mg an effective, well-tolerated antihistamine for allergy management.

AERIALLERG 5mg Interactions AERIALLERG 5mg

Desloratadine has a relatively low potential for clinically significant drug interactions but certain considerations are important to optimize safety and efficacy.

• CYP450 Enzyme Interactions: Desloratadine is metabolized primarily by CYP3A4 and CYP2D6. Co-administration with strong inhibitors like ketoconazole, erythromycin, or inducers like rifampicin may alter desloratadine levels, although clinically relevant interactions are rare.
• Alcohol: Although desloratadine is minimally sedating, concurrent use with alcohol may increase drowsiness in susceptible individuals and should be avoided or minimized.
• CNS Depressants: Concomitant use with sedatives or tranquilizers might potentiate CNS depression and should be done cautiously.
• Other Antihistamines: Combining with other H₁ antihistamines is generally unnecessary and may increase the risk of side effects.
• Antacids and Food: No significant interactions with antacids or food, allowing flexible administration.
• Herbal Supplements: Inform your doctor if using supplements such as St. John’s Wort, which may affect metabolism.

Always disclose all medications and supplements to your healthcare provider to avoid potential interactions with AERIALLERG 5mg.

Dosage of AERIALLERG 5mg

Correct dosing of AERIALLERG 5mg tablets is key to achieving therapeutic goals while minimizing adverse effects.

• Adults and Adolescents (≥12 years): The standard dose is one 5 mg tablet once daily.
• Children under 12 years: AERIALLERG 5mg tablets are generally not recommended; syrup or other pediatric formulations are preferred.
• Elderly Patients: No specific dose adjustments are usually necessary, but caution is advised based on clinical status.
• Hepatic and Renal Impairment: Dose adjustments are typically not required for mild to moderate impairment; severe cases should be monitored.
• Duration of Treatment: Treatment duration depends on the clinical condition, often continued for the duration of allergen exposure or chronic symptoms, as advised by a healthcare provider.
• Administration: Once-daily dosing is convenient and improves patient adherence.

Adhering to the prescribed dosage ensures maximum efficacy and safety in allergy symptom management with AERIALLERG 5mg.

Possible side effects of AERIALLERG 5mg

While generally well tolerated, AERIALLERG 5mg tablets may cause side effects in some patients. Most are mild and transient.

• Common Side Effects:
  • Headache
  • Dry mouth
  • Fatigue or mild drowsiness
  • Nausea
• Less Common Side Effects:
  • Dizziness
  • Gastrointestinal discomfort such as abdominal pain or diarrhea
  • Pharyngitis or throat irritation
• Rare but Serious Reactions:
  • Allergic reactions including rash, itching, swelling, or anaphylaxis
  • Palpitations or irregular heartbeat
• Precautions: If any severe or unusual symptoms occur, discontinue use and seek medical attention immediately.

Patients should report persistent or worsening side effects to their healthcare provider for appropriate management.

AERIALLERG 5mg Contraindications AERIALLERG 5mg

AERIALLERG 5mg should not be used in the following cases to prevent adverse outcomes:

• Hypersensitivity: Known allergy to desloratadine, loratadine, or any excipients in the formulation.
• Severe Liver Impairment: Caution advised; severe hepatic dysfunction may require alternative therapies or close monitoring.
• Children Under 12 Years: Not recommended due to lack of appropriate dosing and safety data.
• Pregnancy and Lactation: Use only if benefits outweigh risks and under strict medical supervision.
• Concomitant Use: Avoid combining with other H₁ antihistamines unless prescribed.

Adhering to contraindications ensures patient safety and effective treatment outcomes.

Storage of AERIALLERG 5mg

Proper storage of AERIALLERG 5mg tablets maintains their potency and safety over time.

• Temperature: Store at room temperature, preferably between 15°C and 30°C (59°F to 86°F).
• Humidity: Keep tablets in the original blister pack until use to protect from moisture.
• Light Protection: Store away from direct sunlight and bright light.
• Container: Keep in a tightly closed container or blister pack to prevent contamination.
• Out of Reach: Keep out of reach of children to prevent accidental ingestion.
• Expiry Date: Do not use after the expiration date indicated on the packaging.
• Disposal: Dispose of expired or unused medication according to local guidelines or pharmacy advice.

Following these storage guidelines ensures the medication remains safe and effective throughout its shelf life.