AERIALLERG 0.5mg/ml Syrup

What is AERIALLERG 0.5mg/ml

AERIALLERG 0.5mg/ml is a medicinal syrup formulation containing the active ingredient Desloratadine, which belongs to the class of second-generation antihistamines. It is specifically developed to treat allergic conditions by alleviating symptoms caused by histamine release in the body.

• Form: Oral syrup, supplied in a 125 ml amber glass bottle to protect the solution from light degradation.
• Active Ingredient: Desloratadine at a concentration of 0.5 mg per ml.
• Indications: Used to manage allergic rhinitis (both seasonal and perennial), chronic idiopathic urticaria (hives), and other allergic manifestations such as itching, sneezing, nasal congestion, watery eyes, and skin rashes.
• Non-Sedating: As a second-generation antihistamine, AERIALLERG causes minimal sedation or drowsiness compared to older antihistamines.
• Patient Population: Suitable for children and adults who require effective allergy symptom relief through a convenient syrup formulation, especially useful for those who have difficulty swallowing tablets.
• Benefits: Provides rapid relief of allergy symptoms, improves quality of life, and has a favorable safety profile.

Overall, AERIALLERG 0.5mg/ml is a reliable choice for symptomatic treatment of allergic conditions requiring antihistaminic therapy.

How to use AERIALLERG 0.5mg/ml

Proper usage of AERIALLERG syrup ensures maximum therapeutic benefit while minimizing potential adverse effects.

• Dosage Measurement: Use the measuring device or calibrated spoon provided with the medication to ensure accurate dosing.
• Administration: Taken orally, with or without food. Consistency in timing daily improves effectiveness.
• Typical Dosing: The dosage varies depending on age and severity of symptoms. For children, dose adjustments should be based on weight and pediatric recommendations.
• Duration: Treatment duration depends on clinical indication. For seasonal allergies, it may be used throughout the allergy season; for chronic conditions, as prescribed by a healthcare professional.
• Missed Dose: If a dose is missed, take it as soon as remembered unless it’s near the time for the next dose. Do not double doses.
• Precautions: Avoid alcohol consumption during treatment as it may enhance drowsiness in some individuals.
• Consultation: Always follow the prescribing physician's instructions and consult them if symptoms persist or worsen despite treatment.

Adherence to recommended usage instructions ensures the best possible control of allergic symptoms with AERIALLERG syrup.

Mode of Action AERIALLERG 0.5mg/ml

AERIALLERG 0.5mg/ml exerts its therapeutic effects by selectively blocking histamine H₁ receptors, thereby preventing the action of histamine, a chemical mediator responsible for many allergic symptoms.

• Histamine Role: Histamine is released from mast cells during allergic reactions, leading to symptoms such as vasodilation, increased vascular permeability, itching, and bronchoconstriction.
• Selective H₁ Receptor Antagonism: Desloratadine competitively binds to peripheral H₁ receptors without crossing the blood-brain barrier significantly, minimizing sedation.
• Anti-Inflammatory Properties: Besides blocking histamine effects, desloratadine may reduce the release of other pro-inflammatory mediators, contributing to decreased tissue inflammation.
• Onset and Duration: Rapid onset of action typically within 1-3 hours, with a long half-life allowing once-daily dosing and sustained symptom control.
• Impact on Symptoms: Relief of nasal congestion, sneezing, itching, rhinorrhea, and skin manifestations associated with allergic reactions.

In summary, AERIALLERG 0.5mg/ml provides effective symptomatic relief by blocking histamine-induced responses without causing significant sedation.

AERIALLERG 0.5mg/ml Interactions AERIALLERG 0.5mg/ml

Desloratadine, the active ingredient in AERIALLERG, has a relatively low potential for drug interactions; however, some interactions should be considered to avoid adverse effects or altered efficacy.

• Cytochrome P450 Inhibitors/Inducers: Desloratadine is metabolized primarily by CYP3A4 and CYP2D6 enzymes. Co-administration with strong inhibitors (e.g., ketoconazole, erythromycin) or inducers (e.g., rifampicin, carbamazepine) may affect desloratadine plasma levels.
• Alcohol: While desloratadine is less sedating, alcohol may potentiate central nervous system depressant effects and should be avoided.
• CNS Depressants: Concomitant use with sedatives, tranquilizers, or other antihistamines can increase sedation risk.
• Other Antihistamines: Combined use may increase the risk of additive side effects without improving efficacy.
• Antacids: No significant interactions have been reported, but timing of administration can help maximize absorption.
• Food Interactions: Food does not significantly affect desloratadine absorption, allowing flexible dosing in relation to meals.

Always inform your healthcare provider about all medications and supplements to ensure safe use of AERIALLERG syrup and avoid potential interactions.

Dosage of AERIALLERG 0.5mg/ml

Proper dosing of AERIALLERG 0.5mg/ml syrup is essential to achieve optimal symptom relief and minimize side effects. Dosage varies by age and clinical condition.

• Adults and Adolescents (12 years and older): Typically, 5 mg once daily, equivalent to 10 ml of the syrup.
• Children (6-11 years): Usually 2.5 mg once daily, corresponding to 5 ml of the syrup.
• Children (1-5 years): Dose is generally 1.25 mg once daily, or 2.5 ml of the syrup, depending on weight and physician guidance.
• Administration: Once daily dosing is preferred to maintain steady therapeutic levels.
• Special Populations: In patients with hepatic or renal impairment, dose adjustment is typically not required but should be considered on a case-by-case basis.
• Duration of Treatment: Usually continued for the duration of allergen exposure or symptoms. Long-term use should be supervised by a healthcare provider.

Follow the exact dosing instructions provided by the healthcare professional or product labeling to ensure safe and effective treatment with AERIALLERG syrup.

Possible side effects of AERIALLERG 0.5mg/ml

While AERIALLERG syrup is generally well tolerated, some patients may experience side effects. Most adverse reactions are mild and transient.

• Common Side Effects:
  • Headache
  • Dry mouth
  • Fatigue or mild drowsiness (less frequent than first-generation antihistamines)
  • Nausea
• Less Common Side Effects:
  • Dizziness
  • Gastrointestinal discomfort (abdominal pain, diarrhea)
  • Pharyngitis or sore throat
• Rare but Serious Reactions:
  • Allergic reactions including rash, itching, swelling, or anaphylaxis (rare)
  • Palpitations or rapid heartbeat (very rare)
• Precautions: If any signs of hypersensitivity or severe adverse reactions occur, stop the medication immediately and seek medical attention.

Patients are advised to report any unusual or persistent symptoms to their healthcare provider promptly for appropriate evaluation and management.

AERIALLERG 0.5mg/ml Contraindications AERIALLERG 0.5mg/ml

AERIALLERG syrup should not be used in certain situations to avoid potential harm or ineffective treatment.

• Hypersensitivity: Known allergy or hypersensitivity to desloratadine, loratadine, or any component of the formulation.
• Severe Liver Impairment: Caution advised; although not an absolute contraindication, severe hepatic dysfunction may necessitate dosage adjustments.
• Age Restrictions: Generally not recommended for children under 1 year of age unless specifically prescribed by a pediatrician.
• Pregnancy and Lactation: Use only if clearly needed and under medical supervision, as safety data is limited.
• Concomitant Use with Certain Drugs: Avoid combining with other sedating drugs without medical advice.

Always inform your healthcare provider of your full medical history before starting AERIALLERG syrup.

Storage of AERIALLERG 0.5mg/ml

Proper storage of AERIALLERG syrup ensures its stability and effectiveness throughout its shelf life.

• Temperature: Store at room temperature, ideally between 15°C and 30°C (59°F to 86°F). Avoid excessive heat or cold.
• Light Protection: Keep the syrup in its original amber glass bottle to protect it from light which may degrade the active ingredient.
• Moisture: Keep the bottle tightly closed to prevent contamination and moisture ingress.
• Shelf Life: Check the expiration date on the bottle and do not use beyond this date.
• Children Safety: Store out of reach of children to prevent accidental ingestion.
• Disposal: Dispose of any unused or expired medicine responsibly according to local regulations or pharmacy advice.

Adhering to these storage instructions will help maintain the quality and safety of AERIALLERG 0.5mg/ml syrup.