What is ADVAGRAF 3mg
ADVAGRAF 3mg is a prolonged-release oral capsule formulation containing tacrolimus, an immunosuppressant drug. It is primarily prescribed to prevent organ rejection in patients who have undergone solid organ transplantation, including kidney, liver, or heart transplants.
ADVAGRAF’s prolonged-release design allows for once-daily administration, providing a consistent and steady blood concentration of tacrolimus. This steadiness enhances patient adherence by simplifying the dosing schedule and helps maintain optimal immunosuppressive levels to protect the transplanted organ from immune system attacks.
- Active ingredient: Tacrolimus
- Dosage form: Hard gelatin capsule, prolonged-release
- Strength: 3 mg per capsule
- Packaging: 100 capsules (2 pouches of 50 capsules each, blister packed)
- Therapeutic class: Calcineurin inhibitor immunosuppressant
- Indications: Prevention of rejection in kidney, liver, and heart transplantation
How to use ADVAGRAF 3mg
Correct usage of ADVAGRAF 3mg is essential to ensure effective immunosuppression while minimizing adverse effects:
- Dosage schedule: Taken once daily, preferably at the same time each day to maintain steady blood levels.
- Swallow whole: Capsules should be swallowed intact; do not crush, chew, or open them as this will disrupt the prolonged-release mechanism.
- Food considerations: It can be taken with or without food. However, consistency is important, since food intake can affect absorption.
- Monitoring: Regular blood tests are necessary to monitor tacrolimus trough levels and adjust the dose accordingly.
- Missed dose: If a dose is missed, take it as soon as possible unless it is close to the next dose. Do not double the dose.
- Do not stop abruptly: Stopping tacrolimus suddenly can lead to transplant rejection; any changes must be made under medical supervision.
- Inform healthcare provider: Always inform your doctor about all medications and supplements you are taking.
Mode of Action ADVAGRAF 3mg
Tacrolimus, the active ingredient in ADVAGRAF, suppresses the immune system by specifically targeting T-lymphocytes, which play a central role in organ rejection:
- Intracellular binding: Tacrolimus binds to FK-binding protein 12 (FKBP-12) inside T-cells.
- Calcineurin inhibition: The tacrolimus-FKBP-12 complex inhibits calcineurin, an enzyme critical for activating nuclear factor of activated T-cells (NF-AT).
- Prevention of cytokine production: This inhibition blocks transcription of interleukin-2 (IL-2) and other cytokines necessary for T-cell activation and proliferation.
- Immunosuppression: The net effect is reduced T-cell response and prevention of immune-mediated attack on the transplanted organ.
- Selective mechanism: Tacrolimus targets cell-mediated immunity while sparing other immune functions to some extent.
ADVAGRAF 3mg Interactions ADVAGRAF 3mg
ADVAGRAF has significant interactions with many medications, primarily due to its metabolism via the CYP3A4 enzyme system:
- CYP3A4 inhibitors: Drugs such as ketoconazole, erythromycin, clarithromycin, fluconazole, and protease inhibitors can increase tacrolimus blood levels, increasing toxicity risk.
- CYP3A4 inducers: Rifampicin, carbamazepine, phenytoin, St. John's Wort can lower tacrolimus levels, risking transplant rejection.
- Nephrotoxic agents: Concurrent use with NSAIDs, amphotericin B, aminoglycosides may exacerbate kidney damage.
- Calcium channel blockers: Verapamil and diltiazem can increase tacrolimus levels.
- Grapefruit juice: Inhibits CYP3A4 and may elevate tacrolimus levels; consumption should be avoided.
- Other immunosuppressants: Often co-administered, requiring careful dose adjustment and monitoring to avoid additive toxicity.
Patients should always disclose their full medication list to their healthcare provider to manage interactions properly.
Dosage of ADVAGRAF 3mg
Dosage of ADVAGRAF 3mg must be individualized and carefully monitored:
- Initial dosing: Usually starts at 0.1-0.2 mg/kg body weight once daily, initiated within 12 to 24 hours after transplantation.
- Maintenance dose: Adjusted based on blood trough levels, aiming for 5-15 ng/mL depending on time post-transplant and type of organ transplanted.
- Therapeutic drug monitoring: Essential to tailor dosing, minimize toxicity, and prevent under-immunosuppression.
- Special populations: Dose adjustments may be required for patients with hepatic or renal impairment, elderly patients, or pediatrics.
- Missed dose: Take as soon as remembered unless it is almost time for the next dose; never double dose.
Possible side effects of ADVAGRAF 3mg
p>ADVAGRAF has a range of potential side effects, which require close monitoring:
- Nephrotoxicity: Most common and serious; may manifest as elevated serum creatinine or reduced kidney function.
- Neurotoxicity: Tremors, headaches, insomnia, dizziness, seizures in severe cases.
- Increased infection risk: Due to immunosuppression, patients may develop bacterial, viral, or fungal infections.
- Hypertension: High blood pressure is frequently reported.
- Metabolic disturbances: Hyperglycemia, new-onset diabetes, hyperkalemia, hypomagnesemia.
- Gastrointestinal effects: Nausea, diarrhea, abdominal discomfort.
- Other: Alopecia, rash, fatigue, electrolyte imbalances.
- Serious adverse events: Allergic reactions, severe infections, and neurologic complications require urgent medical attention.
ADVAGRAF 3mg Contraindications ADVAGRAF 3mg
ADVAGRAF should be avoided or used with extreme caution in the following situations:
- Hypersensitivity: Known allergy to tacrolimus or any capsule components.
- Active infections: Severe infections are contraindications due to immunosuppressive effects.
- Live vaccines: Contraindicated because of impaired immune response.
- Pregnancy and breastfeeding: Use only if benefits outweigh risks, as tacrolimus may harm the fetus or infant.
- Severe hepatic impairment: Dose adjustments needed; caution required due to altered metabolism.
Storage of ADVAGRAF 3mg
Proper storage conditions ensure medication stability and safety:
- Temperature: Store at controlled room temperature (20°C to 25°C or 68°F to 77°F).
- Packaging: Keep capsules in original blister packs to protect from moisture and light.
- Keep out of reach: Store away from children and pets.
- Avoid extreme conditions: Do not freeze or expose to excessive heat.
- Expiry date: Do not use after the printed expiry date.
ADVAGRAF 3mg features an exceptional active ingredient renowned for its potent effects, comprising Tacrolimus. This powerful formulation provides a superior solution for addressing diverse health concerns. With 3mg/Capsule concentration and an easily manageable Capsules (Hard Gelatin)/Prolonged Release, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADVAGRAF 3mg .
Welcome to Dwaey, specifically on ADVAGRAF 3mg page.
This medicine contains an important and useful components, as it consists of Tacrolimus.
ADVAGRAF 3mg is available in the market in concentration 3mg/Capsule and in the form of Capsules (Hard Gelatin)/Prolonged Release.
HIKMA PHARMACEUTICALS is the producer of ADVAGRAF 3mg and it is imported from JORDAN,
The most popular alternatives of ADVAGRAF 3mg are listed downward .
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Active Substance
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Size
100Õs [50 s (10 s Blister x 5) Pouch x 2]
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Indications
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Type
Capsules (Hard Gelatin)/Prolonged Release
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Company
Frequently Asked Questions
ADVAGRAF 3mg should be stored according to the instructions provided by HIKMA PHARMACEUTICALS.
In general, it is recommended to store ADVAGRAF 3mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADVAGRAF 3mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADVAGRAF 3mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADVAGRAF 3mg. Some medications, including
ADVAGRAF 3mg, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADVAGRAF 3mg, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADVAGRAF 3mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADVAGRAF 3mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADVAGRAF 3mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 3mg/Capsule,
and the specific recommendations of HIKMA PHARMACEUTICALS.
The effects of ADVAGRAF 3mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 3mg/Capsule, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADVAGRAF 3mg with or without food may vary depending on the medication
and the recommendations of HIKMA PHARMACEUTICALS. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADVAGRAF 3mg in children or elderly individuals may depend on various factors, including
the specific medication, type Capsules (Hard Gelatin)/Prolonged Release, and the recommendations of HIKMA PHARMACEUTICALS. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADVAGRAF 3mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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