What is ADOL ALLERGY SINUS
ADOL ALLERGY SINUS is an over-the-counter combination cold and allergy preparation formulated as caplets containing three active ingredients: paracetamol (acetaminophen) 500 mg, the antihistamine chlorpheniramine maleate 4 mg, and the nasal decongestant pseudoephedrine hydrochloride 30 mg (typical per-caplet strengths; always check the outer carton). It is designed to provide multi-symptom relief for the overlap of allergic rhinitis and common-cold–related discomfort, specifically targeting fever, headache, sinus pressure, nasal congestion, sneezing, watery eyes, and rhinorrhea.
- Therapeutic class: Analgesic-antipyretic, first-generation antihistamine, sympathomimetic decongestant.
- Intended population: Adults and adolescents ≥12 years who require simultaneous relief of upper-respiratory allergic symptoms and sinus congestion.
- Presentation: 24 caplets packed as two 12-count PVC/PVdC blisters to preserve stability and discourage moisture ingress.
- Regulatory status: Non-prescription in many regions but may be kept “behind-the-counter” owing to pseudoephedrine content; photo ID or purchase quantity limits may apply.
- Rationale for fixed-dose combination: The three components act on distinct yet complementary pharmacologic targets—prostaglandin-mediated pain/fever pathways, histamine H₁ receptors, and α-adrenergic vascular receptors—thereby reducing pill burden and improving adherence during acute episodes.
Because it contains an oral sympathomimetic, ADOL ALLERGY SINUS is unsuitable for chronic use; therapy should be limited to ≤7 consecutive days (≤3 days for fever) unless directed by a healthcare professional.
How to use ADOL ALLERGY SINUS
Correct use maximizes symptom control while minimizing adverse effects:
- Adults & adolescents ≥12 years: One caplet every 4–6 hours as needed. Do not exceed six caplets (3 g paracetamol) in 24 hours.
- Administration: Swallow whole with a full glass of water. Caplets may be taken with or without food; a light snack can reduce gastric upset in sensitive patients.
- Duration: Discontinue once symptoms resolve or after 7 days (3 days for persistent fever). Seek medical evaluation if symptoms worsen, new symptoms appear, or high fever recurs.
- Hydration: Adequate fluid intake helps loosen nasal secretions and supports renal clearance of paracetamol metabolites.
- Avoid duplicate therapy: Check all concomitant OTC/“cold & flu” products to prevent inadvertent paracetamol or pseudoephedrine overdose.
- Night-time dosing: Chlorpheniramine’s sedative effect may aid sleep, but caution patients about next-day drowsiness. If daytime alertness is critical (e.g., driving), schedule the last dose ≥4 hours before activities requiring mental acuity.
Missed dose: Skip and resume the regular schedule when needed; do not double up. Special populations: Not recommended for children <12 years. In hepatic impairment or chronic alcohol use, total daily paracetamol should stay <2 g; consult a prescriber.
Mode of Action ADOL ALLERGY SINUS
- Paracetamol (acetaminophen): Centrally inhibits cyclo-oxygenase-2–mediated prostaglandin synthesis within the hypothalamic thermoregulatory center and dorsal horn of the spinal cord, producing antipyretic and analgesic effects without significant peripheral anti-inflammatory activity.
- Chlorpheniramine maleate: A first-generation H₁-receptor inverse agonist that competitively blocks histamine at the H₁ receptor within bronchial, nasal, and conjunctival tissues, thereby reducing sneezing, pruritus, lacrimation, and rhinorrhea. Its lipophilicity permits blood–brain-barrier penetration, accounting for sedation and anti-emetic properties.
- Pseudoephedrine HCl: A stereoisomer of ephedrine with potent indirect (norepinephrine release) and direct α-adrenergic agonist activity on nasal mucosal arterioles. Vasoconstriction decreases vascular engorgement of the turbinates and paranasal sinuses, restoring airway patency and reducing sinus pressure. Mild β-adrenergic activity can elevate heart rate in susceptible individuals.
The synergy among these mechanisms provides broad symptom relief: paracetamol addresses systemic malaise and headache; chlorpheniramine attenuates allergic cascades; and pseudoephedrine rapidly decongests. The formulation’s pharmacokinetics afford onset within 30–60 minutes and duration ≈4–6 hours.
ADOL ALLERGY SINUS Interactions ADOL ALLERGY SINUS
Clinically important interactions stem from each component’s metabolism and pharmacodynamics:
- MAO inhibitors (e.g., linezolid, phenelzine): Risk of hypertensive crisis or serotonin toxicity with pseudoephedrine; contraindicated within 14 days.
- Selective & reversible MAO-A inhibitors (moclobemide): Similar hypertensive potential; avoid.
- Other sympathomimetics (phenylephrine, caffeine-containing stimulants): Additive blood-pressure and heart-rate elevation.
- CNS depressants (benzodiazepines, opioids, alcohol): Potentiation of chlorpheniramine-induced sedation and psychomotor impairment.
- Hepatotoxic agents (isoniazid, high-dose rifampin, chronic ethanol): Increased risk of paracetamol-related hepatocellular injury; consider reducing paracetamol exposure and monitoring liver enzymes.
- Warfarin & other vitamin-K antagonists: Regular paracetamol (≥1.3 g/day for >5 days) can elevate INR; sporadic use is generally safe but monitor if prolonged.
- Anticholinergics (tricyclic antidepressants, antispasmodics): Additive dry mouth, urinary retention, and blurred vision from chlorpheniramine.
- Beta-blockers & antihypertensives: Pseudoephedrine may blunt antihypertensive efficacy; patients with controlled hypertension should monitor BP.
Always obtain a full medication and supplement history. When uncertainty exists, pharmacists can perform real-time interaction checks.
Dosage of ADOL ALLERGY SINUS
- Standard dosing (≥12 years): 1 caplet every 4–6 hours PRN.
- Maximum daily dose: 6 caplets (3 g paracetamol, 180 mg pseudoephedrine, 24 mg chlorpheniramine).
- Renal impairment: With eGFR <30 mL/min/1.73 m², extend interval to every 8 hours and limit to 4 caplets/day, because pseudoephedrine is renally cleared.
- Hepatic impairment or chronic alcoholism: Do not exceed 4 caplets/day (2 g paracetamol). Monitor for early signs of hepatotoxicity (nausea, right-upper-quadrant pain).
- Elderly (≥65 years): Start with ½–1 caplet every 6 hours; sedation and anticholinergic burden may necessitate lower dosing.
- Pediatric use: Contraindicated in children <12 years due to pseudoephedrine and anticholinergic effects.
- Missed dose: Because therapy is symptom-driven, take next dose when needed, observing minimum interval.
Exceeding recommended paracetamol limits is the leading cause of acute liver failure; emphasize dose-tracking tools or mobile apps for at-risk patients.
Possible side effects of ADOL ALLERGY SINUS
p>Most adverse reactions are mild and transient; nevertheless, educate users to recognize warning signs:
- Nervous system: Drowsiness, impaired concentration, or paradoxical CNS stimulation (insomnia, nervousness) particularly with pseudoephedrine in adolescents.
- Gastrointestinal: Nausea, epigastric discomfort; rarely, hepatotoxicity at cumulative paracetamol doses >4 g/24 h or with ethanol abuse.
- Cardiovascular: Palpitations, tachycardia, mild blood-pressure elevation; hypertensive crisis is rare but possible with inadvertent MAOI co-use.
- Anticholinergic: Dry mouth, blurred vision, constipation, urinary hesitancy—more pronounced in older males with prostatic hypertrophy.
- Allergic: Pruritus, urticaria; severe cutaneous adverse reactions (SCARs) such as Stevens–Johnson syndrome from paracetamol are extraordinarily rare (estimated <1 / 1,000,000).
- Hematologic: Very rare thrombocytopenia or agranulocytosis; report persistent fever or sore throat.
- Psychiatric: Vivid dreams or anxiety linked to chlorpheniramine’s central activity.
- Overdose symptoms: Early (0–24 h): nausea, diaphoresis; Late (24–72 h): right-upper-quadrant pain, jaundice (paracetamol hepatotoxicity); Sympathomimetic toxidrome: severe hypertension, arrhythmias.
Prompt medical attention is mandatory if hepatic pain, skin blistering, or abnormal bleeding occurs.
ADOL ALLERGY SINUS Contraindications ADOL ALLERGY SINUS
- Known hypersensitivity to paracetamol, chlorpheniramine, pseudoephedrine, or any formulation excipients.
- Severe uncontrolled hypertension, coronary artery disease, or arrhythmias due to sympathomimetic risk.
- Narrow-angle glaucoma or severe urinary retention (e.g., bladder neck obstruction, severe BPH) exacerbated by anticholinergic effects.
- Active severe hepatic impairment or acute liver disease.
- Concurrent or recent (within 14 days) MAO inhibitor therapy.
- Pheochromocytoma (catecholamine-sensitive tumors).
- Children under 12 years.
Pregnancy category varies by region; pseudoephedrine exposure in first trimester has been linked to rare fetal gastroschisis—use only if benefits outweigh risks. Lactation: all three components pass into breast-milk; monitor infant for irritability or sedation.
Storage of ADOL ALLERGY SINUS
- Temperature: Store below 25 °C (77 °F). Short excursions up to 30 °C are acceptable, but prolonged heat accelerates pseudoephedrine degradation and can swell blisters.
- Humidity: Keep in original foil-backed blister until use. Moisture ingress may discolor caplets and compromise tablet hardness.
- Light: Paracetamol is photostable; however, chlorpheniramine may fade—protect from direct sunlight.
- Child safety: Because accidental pediatric ingestion can be fatal, especially from pseudoephedrine sympathomimetic effects, store above eye-level in child-resistant containers or locked cabinets.
- Disposal: Expired or unused caplets should be returned to pharmacy take-back programs or mixed with inedible material (e.g., coffee grounds) in a sealed bag before household trash if no program is available. Do not flush.
- Stability: Typical shelf-life is 36 months from manufacture; check carton for exact expiry. Altered appearance (chipping, odor) warrants safe disposal regardless of date.
Maintaining proper storage preserves potency and ensures predictable onset, safeguarding both efficacy and safety.
ADOL ALLERGY SINUS features an exceptional active ingredient renowned for its potent effects, comprising Paracetamol, Chlorpheniramine maleate, Pseudoephedrine HCl. This powerful formulation provides a superior solution for addressing diverse health concerns. With 325mg, 2mg, 30mg/Tablet concentration and an easily manageable Tablets (Caplets), it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADOL ALLERGY SINUS .
Welcome to Dwaey, specifically on ADOL ALLERGY SINUS page.
This medicine contains an important and useful components, as it consists of Paracetamol, Chlorpheniramine maleate, Pseudoephedrine HCl.
ADOL ALLERGY SINUS is available in the market in concentration 325mg, 2mg, 30mg/Tablet and in the form of Tablets (Caplets).
JULPHAR (GULF PHARMACEUTICAL INDUSTRIES) is the producer of ADOL ALLERGY SINUS and it is imported from UAE,
The most popular alternatives of ADOL ALLERGY SINUS are listed downward .
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Active Substance
Paracetamol, Chlorpheniramine maleate, Pseudoephedrine HCl
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Size
-
Indications
- No indications available.
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Type
-
Company
JULPHAR (GULF PHARMACEUTICAL INDUSTRIES)
Frequently Asked Questions
ADOL ALLERGY SINUS should be stored according to the instructions provided by JULPHAR (GULF PHARMACEUTICAL INDUSTRIES).
In general, it is recommended to store ADOL ALLERGY SINUS in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADOL ALLERGY SINUS may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADOL ALLERGY SINUS for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADOL ALLERGY SINUS. Some medications, including
ADOL ALLERGY SINUS, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADOL ALLERGY SINUS, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADOL ALLERGY SINUS without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADOL ALLERGY SINUS if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADOL ALLERGY SINUS during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 325mg, 2mg, 30mg/Tablet,
and the specific recommendations of JULPHAR (GULF PHARMACEUTICAL INDUSTRIES).
The effects of ADOL ALLERGY SINUS on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 325mg, 2mg, 30mg/Tablet, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADOL ALLERGY SINUS with or without food may vary depending on the medication
and the recommendations of JULPHAR (GULF PHARMACEUTICAL INDUSTRIES). Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADOL ALLERGY SINUS in children or elderly individuals may depend on various factors, including
the specific medication, type Tablets (Caplets), and the recommendations of JULPHAR (GULF PHARMACEUTICAL INDUSTRIES). Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADOL ALLERGY SINUS in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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