LISAMETHYLE 500 mg Powder for solution for injection

What is LISAMETHYLE 500 mg

LISAMETHYLE 500 mg is a high-dose corticosteroid injection preparation containing the active ingredient Methylprednisolone. This formulation is commonly used in emergency and critical care settings for its powerful anti-inflammatory and immunosuppressive effects. It is supplied as a sterile lyophilized (freeze-dried) powder in a glass vial and must be reconstituted with a compatible solvent before intravenous (IV) administration.

• Generic Name: Methylprednisolone
• Form: Powder for IV solution (to be reconstituted)
• Strength: 500 mg per vial
• Therapeutic Class: Systemic Corticosteroids (Glucocorticoids)
• Common Uses: Severe allergic reactions, autoimmune flares, septic shock, multiple sclerosis, and acute respiratory distress

LISAMETHYLE 500 mg is primarily used when rapid suppression of inflammation or immune response is required. It is typically administered in a hospital setting under close supervision.

How to use LISAMETHYLE 500 mg

The powder must be mixed with a sterile diluent before administration. This should only be performed by a healthcare professional in a sterile environment.

• Use the recommended sterile diluent (e.g., sodium chloride 0.9% or sterile water for injection)
• Inject the solvent into the vial and gently swirl (do not shake vigorously)
• Ensure the powder fully dissolves into a clear solution
• Withdraw the solution into a sterile syringe for IV administration
• Administer as a slow intravenous injection or as an infusion over 15–30 minutes, depending on protocol

Always inspect the solution before administration. Discard if discolored or if particles are visible.

Mode of Action LISAMETHYLE 500 mg

Methylprednisolone is a synthetic glucocorticoid that binds to intracellular glucocorticoid receptors. Upon activation, it alters gene expression to suppress the production of inflammatory cytokines and immune mediators.

• Decreases leukocyte infiltration at inflammation sites
• Suppresses immune response by inhibiting T-cell activation
• Reduces capillary permeability and stabilizes lysosomal membranes
• Inhibits synthesis of prostaglandins and other inflammatory mediators

These effects make it highly effective in controlling inflammation, reducing allergic symptoms, and managing autoimmune diseases.

LISAMETHYLE 500 mg Interactions LISAMETHYLE 500 mg

LISAMETHYLE may interact with other medications, affecting efficacy or increasing risk of adverse effects. Notable interactions include:

• Live vaccines: Avoid due to risk of reduced immune response and infection
• Diabetic medications: Methylprednisolone may increase blood glucose levels
• NSAIDs: Increased risk of gastrointestinal ulceration or bleeding
• Warfarin: Corticosteroids may enhance or reduce anticoagulant effect
• Diuretics: Risk of hypokalemia (low potassium levels)

Always inform your doctor of all medications, supplements, and herbal products you're taking before starting LISAMETHYLE.

Dosage of LISAMETHYLE 500 mg

• Typical adult dose: 500 mg IV once daily or in divided doses, depending on indication and clinical response
• Short-term pulse therapy: 500 mg to 1 g IV daily for 3–5 days in conditions like multiple sclerosis or lupus nephritis
• Pediatric dose: Based on body weight (e.g., 10–30 mg/kg/day IV); must be carefully calculated and monitored by a specialist

Dosage must be individualized and adjusted according to the patient's response and condition. Always follow hospital protocol and physician guidance.

Possible side effects of LISAMETHYLE 500 mg

Common and serious side effects include:

• Immune: Increased susceptibility to infections
• Endocrine: Adrenal suppression, hyperglycemia
• Psychiatric: Insomnia, mood swings, anxiety, or psychosis (especially at high doses)
• Musculoskeletal: Muscle weakness, osteoporosis (with long-term use)
• Gastrointestinal: Nausea, abdominal discomfort, increased risk of ulcers
• Cardiovascular: Hypertension, fluid retention

Serious hypersensitivity reactions are rare but require immediate medical attention.

LISAMETHYLE 500 mg Contraindications LISAMETHYLE 500 mg

• Known allergy to Methylprednisolone or any formulation component
• Systemic fungal infections
• Concurrent administration of live or live-attenuated vaccines
• Active peptic ulcer (use with caution)
• Uncontrolled infections without appropriate antimicrobial therapy

Use with caution in patients with diabetes, hypertension, or a history of psychiatric disorders.

Storage of LISAMETHYLE 500 mg

• Store below 25°C (77°F) in a dry environment
• Keep in the original carton to protect from light
• Do not freeze
• Use immediately after reconstitution; do not store prepared solution unless stated by manufacturer
• Keep out of reach of children

Check the expiry date before use. Do not use if powder shows signs of moisture or discoloration.