LISAMETHYLE 40 mg/2 ml Powder and solvent for solution for injection

What is LISAMETHYLE 40 mg/2 ml

LISAMETHYLE 40 mg/2 ml is a corticosteroid preparation containing Methylprednisolone as its active ingredient. It is presented as a freeze-dried powder in a glass vial with an accompanying ampoule of solvent for reconstitution into an injectable solution. This medication is used for its potent anti-inflammatory and immunosuppressive properties in a wide range of acute and chronic medical conditions.

• Active Ingredient: Methylprednisolone 40 mg per 2 ml (after reconstitution)
• Therapeutic Class: Glucocorticoid / Corticosteroid
• Indications: Allergic reactions, asthma exacerbations, autoimmune diseases, arthritis, and other inflammatory conditions
• Routes of Administration: Intramuscular (IM), Intravenous (IV), or Intra-articular (IA)

It is typically used in hospital or clinical settings for fast, systemic control of severe inflammation or immune responses.

How to use LISAMETHYLE 40 mg/2 ml

The powder must be mixed with the supplied solvent before injection. Administration should only be performed by healthcare professionals.

• Step 1: Break open the solvent ampoule and inject it into the powder vial
• Step 2: Shake gently until the powder dissolves completely into a clear solution
• Step 3: Withdraw the solution into a sterile syringe for injection
• Step 4: Administer via IM, IV, or IA as prescribed

Do not use the solution if it is discolored or contains particles. Single-use only—discard any remaining solution.

Mode of Action LISAMETHYLE 40 mg/2 ml

Methylprednisolone works by mimicking the action of endogenous glucocorticoids. It binds to glucocorticoid receptors and modifies gene transcription, resulting in broad anti-inflammatory and immunosuppressive effects.

• Reduces the release of pro-inflammatory cytokines and mediators
• Suppresses leukocyte (white blood cell) migration to sites of inflammation
• Stabilizes cell membranes, including those of inflammatory cells
• Decreases capillary permeability to reduce swelling and redness

These actions make LISAMETHYLE effective in treating both acute and chronic inflammatory conditions.

LISAMETHYLE 40 mg/2 ml Interactions LISAMETHYLE 40 mg/2 ml

Caution should be exercised when LISAMETHYLE is used with other medications due to potential interactions:

• NSAIDs: Higher risk of gastrointestinal ulcers or bleeding
• Antidiabetics: May reduce glycemic control, requiring dose adjustment
• Anticoagulants (e.g., warfarin): May affect clotting times—monitor INR closely
• Live Vaccines: Avoid during corticosteroid therapy due to immune suppression
• Diuretics: Risk of hypokalemia (low potassium levels)

Always inform your healthcare provider about all other medications and supplements you are taking.

Dosage of LISAMETHYLE 40 mg/2 ml

• Adults: 40–120 mg per dose, depending on the condition and severity
• Children: Usually 0.5–1.5 mg/kg/day or as directed by a pediatric specialist
• Intra-articular Use: 10–40 mg per joint (based on joint size and inflammation)

Dosage must be individualized by a healthcare provider based on clinical assessment. Prolonged use should be avoided unless absolutely necessary.

Possible side effects of LISAMETHYLE 40 mg/2 ml

Methylprednisolone, especially with repeated or high doses, can cause side effects including:

• Common: Mood changes, restlessness, insomnia, facial flushing
• Gastrointestinal: Indigestion, nausea, stomach ulcers
• Metabolic: Weight gain, increased blood sugar
• Hormonal: Adrenal suppression, Cushingoid features
• Immunological: Increased susceptibility to infections

Rare but serious effects include anaphylactic reactions, tendon rupture (especially with intra-articular use), and psychiatric disturbances.

LISAMETHYLE 40 mg/2 ml Contraindications LISAMETHYLE 40 mg/2 ml

• Allergy or hypersensitivity to methylprednisolone or any corticosteroids
• Systemic fungal infections
• Recent or planned administration of live vaccines
• Peptic ulcer disease or gastrointestinal bleeding (use with caution)
• Severe, uncontrolled infections

Use cautiously in patients with diabetes, glaucoma, or osteoporosis.

Storage of LISAMETHYLE 40 mg/2 ml

• Store below 25°C (77°F) in a dry place
• Protect from light and moisture
• Keep solvent and powder in original packaging until ready to use
• Reconstituted solution should be used promptly and not stored
• Keep out of reach of children

Do not use expired vials or if the powder has discolored or clumped.