LISAMETHYLE 120 mg/2 ml Powder and solvent for solution for injection

What is LISAMETHYLE 120 mg/2 ml

LISAMETHYLE 120 mg/2 ml is a corticosteroid injectable preparation containing Methylprednisolone, a synthetic glucocorticoid used to manage a wide range of inflammatory and autoimmune conditions. This form comes as a lyophilized (freeze-dried) powder in a glass vial that must be reconstituted with the accompanying solvent ampoule prior to administration.

• Active Ingredient: Methylprednisolone 120 mg per 2 ml after reconstitution
• Drug Class: Glucocorticoid / Corticosteroid
• Usage: For systemic anti-inflammatory, immunosuppressive, and anti-allergic therapy
• Route: Administered via intramuscular (IM), intravenous (IV), or intra-articular (IA) injection depending on indication

It is commonly used in emergency settings such as acute asthma, allergic reactions, and rheumatologic flare-ups.

How to use LISAMETHYLE 120 mg/2 ml

LISAMETHYLE should only be prepared and administered by healthcare professionals under aseptic conditions.

• Reconstitute the dry powder using the supplied ampoule of solvent (usually sterile water or saline)
• Gently shake the vial until the powder fully dissolves into a clear solution
• Administer as directed: IV push, IV infusion, IM injection, or locally into joints or soft tissue
• Dosage and route depend on the patient’s condition and severity

Do not use if solution appears discolored or contains particulates. Discard any unused portion after preparation.

Mode of Action LISAMETHYLE 120 mg/2 ml

Methylprednisolone exerts its effects through potent anti-inflammatory and immunosuppressive mechanisms:

• Binds to glucocorticoid receptors: Alters gene expression, reducing inflammatory cytokines
• Stabilizes lysosomal membranes: Minimizes cellular damage during inflammation
• Inhibits leukocyte migration: Reduces swelling and tissue infiltration
• Suppresses immune response: Effective in autoimmune and hypersensitivity disorders

This leads to rapid suppression of inflammation, relief of allergic symptoms, and control of overactive immune responses.

LISAMETHYLE 120 mg/2 ml Interactions LISAMETHYLE 120 mg/2 ml

Methylprednisolone may interact with several medications, requiring monitoring and dose adjustments:

• NSAIDs: Increased risk of gastrointestinal bleeding and ulcers
• Diuretics: Enhanced risk of electrolyte imbalance, particularly hypokalemia
• Antidiabetics: May reduce glycemic control and require insulin adjustments
• Anticoagulants: Variable effects on warfarin activity—monitor INR closely
• Vaccines: Avoid live vaccines during corticosteroid therapy due to immunosuppression

Always inform your physician of all current medications, including herbal supplements.

Dosage of LISAMETHYLE 120 mg/2 ml

Dosage depends on the medical condition, route of administration, and patient response.

• Adults: Commonly 40–120 mg IM/IV daily or in divided doses; can be repeated based on clinical need
• Intra-articular (IA): 20–80 mg per joint depending on size and inflammation
• Children: Dosing by body weight; typically 0.5–2 mg/kg/day IV/IM

Treatment duration may be short-term (acute inflammation) or longer under tapering regimens in chronic cases.

Possible side effects of LISAMETHYLE 120 mg/2 ml

Side effects are dose- and duration-dependent. While short-term injections are generally well-tolerated, prolonged use may result in:

• Common: Insomnia, mood swings, facial flushing, injection site pain
• GI: Indigestion, nausea, ulcer risk with long-term use
• Endocrine: Adrenal suppression, weight gain, Cushingoid appearance
• Musculoskeletal: Muscle wasting, osteoporosis with chronic use
• Immunosuppression: Increased infection risk

Serious reactions such as anaphylaxis are rare but possible during IV administration. Always monitor patients closely post-injection.

LISAMETHYLE 120 mg/2 ml Contraindications LISAMETHYLE 120 mg/2 ml

• Known hypersensitivity to methylprednisolone or other corticosteroids
• Systemic fungal infections
• Recent administration of live or attenuated vaccines
• Untreated active infections unless also receiving antimicrobial therapy
• Peptic ulcer or gastrointestinal bleeding (relative contraindication)

Use caution in patients with diabetes, hypertension, glaucoma, psychiatric disorders, or tuberculosis.

Storage of LISAMETHYLE 120 mg/2 ml

• Store the powder vial below 25°C (77°F), protected from moisture
• Keep solvent ampoule at room temperature, away from direct sunlight
• Reconstituted solution should be used immediately or within a few hours as directed
• Keep out of reach of children

Do not freeze. Discard if the powder is discolored or if the solution becomes cloudy after mixing.