LIPOVENOS 20% Infusion/Solution for

What is LIPOVENOS 20%

LIPOVENOS 20% is a sterile, non-pyrogenic intravenous fat emulsion used for parenteral nutrition. It provides essential fatty acids and energy for patients who are unable to eat or absorb nutrients through the gastrointestinal tract. This formulation combines Refined Soybean Oil (a source of long-chain triglycerides), Purified Egg Lecithin (an emulsifying agent), and Glycerol (to make the solution isotonic).

• Purpose: Supplies calories and essential fatty acids in clinical nutrition
• Formulation: 20% fat emulsion
• Administration Route: Intravenous infusion only
• Indications: Parenteral nutrition in hospitalized or critically ill patients

It is often used in combination with other nutritional solutions such as amino acids and glucose to provide complete parenteral nutrition (TPN).

How to use LIPOVENOS 20%

LIPOVENOS 20% should only be administered in a clinical setting under the supervision of a healthcare provider. It must be infused intravenously through a central or peripheral vein depending on the total volume and concentration.

• Preparation: Inspect bottle for damage, particulate matter, or separation of emulsion
• Infusion Rate: Should not exceed 0.15 g of fat per kg of body weight per hour
• Compatibility: May be mixed with other nutrients (e.g., amino acids, glucose) under aseptic conditions
• Monitoring: Watch for signs of fat overload syndrome, allergic reactions, or hyperlipidemia

Do not use if the emulsion appears separated or creamy. Always follow hospital protocols for infusion practices.

Mode of Action LIPOVENOS 20%

LIPOVENOS 20% provides energy-dense long-chain triglycerides (from soybean oil), emulsified by lecithin and suspended in a glycerol-based solution. Upon infusion:

• Fatty Acids: Provide essential building blocks for cell membranes and hormones
• Glycerol: Serves as a source of glucose and energy
• Lecithin: Stabilizes the emulsion and aids in lipid metabolism

The emulsion mimics natural chylomicrons, allowing for uptake into tissues and rapid utilization by cells needing metabolic energy or structural lipids.

LIPOVENOS 20% Interactions LIPOVENOS 20%

Being a nutritional emulsion, LIPOVENOS may interact with other intravenous medications or nutrition components.

• Heparin: May increase lipoprotein lipase activity and impact lipid clearance
• Corticosteroids or Insulin: May influence fat metabolism and serum lipid levels
• Incompatibility: Should not be mixed with electrolytes or drugs without compatibility data
• Warfarin: May be affected by vitamin K content in soybean oil

Compatibility testing and monitoring are essential when LIPOVENOS is part of a total parenteral nutrition (TPN) regimen.

Dosage of LIPOVENOS 20%

• Adults: 1 to 2 g of fat/kg/day, depending on metabolic requirements
• Maximum Rate: Do not exceed 0.15 g fat/kg/hour
• Children & Neonates: Dose based on age, weight, and clinical status—must be prescribed by a pediatric nutrition specialist
• Duration: As determined by patient’s nutritional needs and tolerance

Regular monitoring of triglycerides, liver function, and fluid balance is necessary during administration.

Possible side effects of LIPOVENOS 20%

While generally well tolerated, LIPOVENOS 20% may cause adverse reactions, especially if administered improperly or in patients with preexisting conditions.

• Common: Headache, nausea, fever, chills, flushing
• Metabolic: Hyperlipidemia, liver enzyme elevation, electrolyte disturbances
• Serious: Fat overload syndrome (rare but life-threatening), hypersensitivity reactions, coagulopathy

Discontinue use and seek medical attention if signs of an allergic reaction or metabolic imbalance occur.

LIPOVENOS 20% Contraindications LIPOVENOS 20%

• Severe hyperlipidemia or lipid metabolism disorders
• Allergy to egg protein, soybean oil, or any component of the emulsion
• Acute thromboembolism or severe liver insufficiency
• Unstable diabetes mellitus or metabolic acidosis without control

Use with caution in patients with renal or hepatic impairment, and only under specialized care.

Storage of LIPOVENOS 20%

• Store between 15°C to 25°C (59°F–77°F)
• Do not freeze; freezing may cause separation of the emulsion
• Keep in original packaging to protect from light
• Use immediately after opening
• Discard unused portion; do not reuse partially used bottles

Proper storage is essential to maintain emulsion integrity and sterility.