LIPOFUNDIN MCT/LCT 20% Infusion/Solution for

What is LIPOFUNDIN MCT/LCT 20%

LIPOFUNDIN MCT/LCT 20% is a sterile intravenous lipid emulsion formulated for parenteral nutrition. It provides essential fatty acids and a concentrated source of energy in the form of lipids for patients who are unable to receive adequate nutrition orally or enterally. This emulsion combines medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) to optimize energy delivery and improve metabolic tolerance.

• Purpose: Supplies essential fatty acids and calories to support patients requiring total or supplemental parenteral nutrition.
• Composition: Contains soybean oil (source of LCT), MCT oil, egg lecithin as an emulsifier, glycerol for isotonicity, and alpha-tocopherol (Vitamin E) as an antioxidant.
• Indications: Used in critically ill, postoperative, or malnourished patients needing intravenous nutritional support.
• Benefit: Helps prevent essential fatty acid deficiency and provides efficient energy metabolism.

How to use LIPOFUNDIN MCT/LCT 20%

This product is administered intravenously under medical supervision.

• Use aseptic technique when preparing and administering the infusion.
• Infuse through a suitable intravenous catheter, preferably a central line.
• Dose and infusion rate depend on patient’s nutritional requirements and clinical status.
• Do not mix with incompatible drugs or solutions unless compatibility is established.
• Monitor patient’s clinical condition and laboratory parameters regularly during therapy.

Mode of Action LIPOFUNDIN MCT/LCT 20%

LIPOFUNDIN MCT/LCT 20% provides energy and essential fatty acids essential for cellular function:

• Medium-chain triglycerides (MCT): Rapidly metabolized in the liver for quick energy supply without the need for carnitine.
• Long-chain triglycerides (LCT): Provide essential fatty acids important for cell membrane integrity and hormone synthesis.
• Egg lecithin: Acts as an emulsifier stabilizing the lipid droplets in solution.
• Alpha-tocopherol (Vitamin E): Protects lipids from oxidative damage.
• Glycerol: Maintains isotonicity of the emulsion to prevent hemolysis during infusion.

LIPOFUNDIN MCT/LCT 20% Interactions LIPOFUNDIN MCT/LCT 20%

Potential interactions include:

• Concurrent use with other lipid emulsions requires monitoring to avoid lipid overload.
• Co-infusion with blood products or incompatible drugs should be avoided unless compatibility is confirmed.
• Drugs affecting lipid metabolism may influence lipid levels during therapy.
• Vitamin K antagonists (e.g., warfarin) effects may be altered by parenteral nutrition components.

Dosage of LIPOFUNDIN MCT/LCT 20%

• Dosage is individualized based on patient’s weight, energy needs, and tolerance.
• Generally, 1 to 2 g/kg/day of lipid is recommended.
• Infusion rates should be controlled to minimize risk of fat overload syndrome.
• Adjust dose according to clinical response and laboratory results.

Possible side effects of LIPOFUNDIN MCT/LCT 20%

Adverse reactions are uncommon but may include:

• Fat overload syndrome (symptoms: fever, anemia, thrombocytopenia, hepatosplenomegaly)
• Hyperlipidemia with elevated triglycerides
• Allergic reactions such as rash, itching, or rarely anaphylaxis
• Local infusion site reactions like phlebitis
• Metabolic disturbances including acidosis or electrolyte imbalance

LIPOFUNDIN MCT/LCT 20% Contraindications LIPOFUNDIN MCT/LCT 20%

• Hypersensitivity to soybean oil, egg lecithin, or any component of the formulation
• Severe hyperlipidemia or disorders of fat metabolism
• Severe liver dysfunction or cholestasis
• Severe coagulation disorders
• Severe respiratory insufficiency or pulmonary edema

Storage of LIPOFUNDIN MCT/LCT 20%

• Store at controlled room temperature (15°C to 25°C)
• Protect from light and avoid freezing
• Use immediately after opening to avoid contamination
• Do not use if emulsion appears separated, discolored, or contains particles
• Keep out of reach of children