ADGLIM 3 Tablets

What is ADGLIM 3

ADGLIM 3 is an oral antidiabetic medication that contains Glimepiride 3 mg as its active ingredient. It belongs to the sulfonylurea class of drugs, which are used in the treatment of type 2 diabetes mellitus. This medication is designed to help lower blood sugar levels in individuals whose hyperglycemia cannot be managed adequately by diet and exercise alone.

• Form: Tablet
• Strength: 3 mg Glimepiride per tablet
• Packaging: 30 tablets (10 tablets per blister, 3 blisters)

ADGLIM 3 is typically prescribed as part of a broader diabetes management plan, including lifestyle changes, dietary modifications, and exercise. It is not suitable for treating type 1 diabetes or diabetic ketoacidosis. Glimepiride works by stimulating the release of insulin from pancreatic beta cells, thus enhancing the body’s ability to manage glucose.

This medication is often used alone or in combination with other antidiabetic agents such as metformin or insulin, depending on the patient's glycemic control needs and physician’s assessment.

How to use ADGLIM 3

ADGLIM 3 should be used exactly as prescribed by your healthcare provider. The timing, dosage, and duration of therapy are tailored to your individual health status, blood glucose levels, and therapeutic response.

• Route: Oral administration
• Dosage form: Tablet (3 mg of Glimepiride)
• Recommended intake: Usually taken once daily with breakfast or the first main meal of the day

Administration instructions:

• Swallow the tablet whole with a glass of water. Do not crush or chew it.
• Take it at the same time each day to maintain consistent blood levels.
• Monitor your blood sugar levels regularly as directed by your physician.
• Do not skip meals after taking the medicine to avoid hypoglycemia.

Important precautions:

• Inform your doctor if you are undergoing surgery, fasting, or under stress, as your medication needs might change.
• Do not adjust the dose on your own without consulting your healthcare provider.
• In case you miss a dose, take it as soon as you remember. If it's near your next dose, skip the missed dose. Never double the dose.

Mode of Action ADGLIM 3

Glimepiride, the active compound in ADGLIM 3, works through multiple mechanisms to reduce elevated blood glucose levels in patients with type 2 diabetes mellitus.

Main mechanisms:

• Stimulation of Insulin Secretion: Glimepiride binds to sulfonylurea receptors on pancreatic β-cells, leading to the closure of ATP-sensitive potassium channels. This results in cell depolarization and the influx of calcium ions, ultimately triggering insulin secretion.
• Peripheral Insulin Sensitivity: It enhances insulin sensitivity in peripheral tissues, improving glucose uptake by skeletal muscle and adipose tissue.
• Reduction in Hepatic Glucose Production: Glimepiride has been shown to have a minor effect in reducing hepatic gluconeogenesis, further contributing to lower fasting glucose levels.

Pharmacokinetics highlights:

• Absorption: Rapidly absorbed after oral administration, with peak plasma levels reached in 2-3 hours.
• Metabolism: Extensively metabolized by the liver into inactive metabolites.
• Elimination: Excreted primarily through the kidneys (urine).

Glimepiride’s long duration of action and once-daily dosing improve patient compliance and offer better glycemic control when used consistently as prescribed.

ADGLIM 3 Interactions ADGLIM 3

Like many antidiabetic medications, ADGLIM 3 (Glimepiride) may interact with other drugs, potentially increasing the risk of hypoglycemia or reducing the drug’s effectiveness. It's crucial to inform your healthcare provider about all medications, supplements, and herbal products you are using.

Drugs that may increase the hypoglycemic effect of Glimepiride:

• Insulin and other oral antidiabetics (e.g., metformin, sitagliptin)
• ACE inhibitors (e.g., enalapril, ramipril)
• MAO inhibitors
• Beta-blockers (e.g., propranolol) – may mask hypoglycemia symptoms
• NSAIDs (e.g., aspirin, ibuprofen)
• Sulfonamides

Drugs that may reduce the hypoglycemic effect:

• Thiazide diuretics (e.g., hydrochlorothiazide)
• Glucocorticoids (e.g., prednisone)
• Phenytoin
• Estrogens and oral contraceptives
• Sympathomimetic drugs (e.g., epinephrine, salbutamol)

Alcohol: Alcohol may enhance the hypoglycemic effect or lead to unpredictable blood sugar fluctuations. Use with caution or avoid.

Monitoring tip: Regular blood glucose monitoring is essential when adding or withdrawing interacting drugs.

Dosage of ADGLIM 3

Dosage of ADGLIM 3 must be individualized based on the patient’s current blood glucose levels, response to therapy, and overall health status.

Standard dosage information:

• Initial dose: Typically 1 to 2 mg once daily, taken with breakfast or the first main meal.
• Titration: Dosage can be adjusted at 1–2 week intervals based on blood glucose response.
• Maximum dose: 8 mg daily
• ADGLIM 3: Contains 3 mg Glimepiride, used as a maintenance dose in patients previously stabilized on lower strengths.

Special populations:

• Elderly: Start at lower doses (1 mg) due to increased sensitivity to hypoglycemia.
• Renal or hepatic impairment: Use with caution; may require lower starting and maintenance doses.
• Children: Safety and efficacy in pediatric populations have not been established.

Patients should not self-adjust their dose. If blood glucose is persistently high or low, consult a physician to review therapy and lifestyle factors.

Possible side effects of ADGLIM 3

ADGLIM 3 (Glimepiride) is generally well-tolerated, but like all medications, it may cause side effects. Monitoring and timely medical consultation can help mitigate these risks.

Common side effects:

• Hypoglycemia (low blood sugar) – symptoms include dizziness, sweating, hunger, shakiness, and confusion.
• Weight gain
• Headache
• Nausea or mild gastrointestinal discomfort

Less common but serious side effects:

• Allergic skin reactions – rash, itching, urticaria
• Visual disturbances, especially at the start of therapy (due to rapid glucose changes)
• Liver dysfunction – elevated liver enzymes or jaundice (rare)
• Hematologic issues – leukopenia, thrombocytopenia (rare)

Hypoglycemia management:

• Always carry fast-acting glucose (e.g., glucose tablets or juice).
• Inform family and friends how to help in case of severe hypoglycemia.

If any side effects persist or worsen, immediate medical advice is recommended.

ADGLIM 3 Contraindications ADGLIM 3

ADGLIM 3 is contraindicated in certain populations where the use of Glimepiride may pose significant health risks.

Absolute contraindications:

• Type 1 diabetes mellitus (insulin-dependent)
• Diabetic ketoacidosis or coma
• Known hypersensitivity to Glimepiride or other sulfonylureas/sulfonamides
• Severe renal or hepatic impairment (due to impaired drug metabolism and excretion)

Relative contraindications (use with caution):

• Pregnancy and lactation – insulin is preferred; Glimepiride can cross the placenta and appear in breast milk.
• Elderly patients – increased sensitivity to hypoglycemia
• Patients with adrenal or pituitary insufficiency

Always perform a thorough medical evaluation before initiating ADGLIM 3, and discontinue it if contraindicated conditions develop during therapy.

Storage of ADGLIM 3

Proper storage of ADGLIM 3 is essential to maintain its stability, efficacy, and safety.

• Temperature: Store below 25°C (77°F).
• Humidity: Keep in a dry place; protect from moisture and humidity.
• Packaging: Keep the tablets in their original blister packs until use to prevent light and air exposure.
• Keep out of reach of children.

Do not use if:

• The tablet is discolored, broken, or shows signs of degradation.
• The packaging is damaged or if the expiry date has passed.

Improper storage may affect the potency of Glimepiride and compromise blood sugar control. Dispose of unused or expired medication according to local pharmaceutical disposal regulations.