LIPOFUNDIN MCT/LCT 10% Infusion/Solution for

What is LIPOFUNDIN MCT/LCT 10%

LIPOFUNDIN MCT/LCT 10% is a sterile intravenous lipid emulsion designed for parenteral nutrition. It serves as a source of essential fatty acids and calories in patients who cannot be fed orally or enterally. This lipid emulsion combines medium-chain triglycerides (MCT) and long-chain triglycerides (LCT), providing an optimized balance for better energy supply and metabolic tolerance.

• Therapeutic use: Provides essential fatty acids and energy for patients requiring total or supplemental parenteral nutrition
• Composition: Soybean oil (LCT), MCT oil, egg lecithin as an emulsifier, glycerol for isotonicity, and alpha-tocopherol (Vitamin E) as an antioxidant
• Target patients: Those with impaired oral or gastrointestinal intake such as critically ill, postoperative, or malnourished patients
• Benefit: Supports nutritional needs, helps prevent essential fatty acid deficiency, and contributes to energy metabolism

How to use LIPOFUNDIN MCT/LCT 10%

LIPOFUNDIN is administered exclusively by intravenous infusion under strict medical supervision.

• Use only after proper aseptic preparation and inspect the emulsion for integrity and absence of particulate matter before administration
• Administer through a central or peripheral venous catheter, as directed by healthcare professional
• Dosage depends on patient's nutritional requirements, clinical condition, and concomitant parenteral nutrition components
• Typically infused over several hours daily, adjusted by the physician
• Do not mix with incompatible medications in the same infusion line unless compatibility is assured

Mode of Action LIPOFUNDIN MCT/LCT 10%

The lipid emulsion provides energy and essential fatty acids necessary for various physiological functions:

• Medium-chain triglycerides (MCT): Rapidly metabolized by the liver, providing quick energy without requiring carnitine for mitochondrial uptake
• Long-chain triglycerides (LCT): Contain essential fatty acids important for cell membrane integrity and hormone synthesis
• Egg lecithin: Acts as an emulsifier to stabilize the lipid droplets in the aqueous solution
• Alpha-tocopherol (Vitamin E): Protects lipids from peroxidation, maintaining emulsion stability and patient safety
• Glycerol: Balances osmolarity for safe infusion

LIPOFUNDIN MCT/LCT 10% Interactions LIPOFUNDIN MCT/LCT 10%

Interactions may affect the safety and efficacy of the lipid emulsion:

• Concomitant use with other lipid-containing solutions requires monitoring to avoid lipid overload
• Co-administration with blood products or certain medications may require separate infusion lines
• High doses of vitamin K antagonists (e.g., warfarin) may interact with parenteral nutrition components affecting coagulation
• Close monitoring is necessary when used with drugs influencing lipid metabolism

Dosage of LIPOFUNDIN MCT/LCT 10%

• Dosage is individualized based on patient's energy needs, lipid tolerance, and overall parenteral nutrition regimen
• Typical dosage ranges from 1 to 2 g/kg body weight of lipid per day
• Administer slowly to avoid hyperlipidemia or fat overload syndrome
• Physician will adjust dose according to laboratory parameters and clinical status

Possible side effects of LIPOFUNDIN MCT/LCT 10%

Adverse reactions may occur but are generally rare when administered correctly.

• Fat overload syndrome characterized by fever, anemia, leukopenia, thrombocytopenia, hepatosplenomegaly
• Hyperlipidemia with elevated serum triglycerides
• Allergic reactions including rash, urticaria, or anaphylaxis (rare)
• Local reactions at infusion site such as phlebitis or thrombophlebitis
• Metabolic disturbances such as acidosis or electrolyte imbalances

LIPOFUNDIN MCT/LCT 10% Contraindications LIPOFUNDIN MCT/LCT 10%

• Hypersensitivity to any of the ingredients including soybean oil or egg lecithin
• Severe hyperlipidemia or disorders of lipid metabolism
• Severe liver dysfunction or cholestasis
• Severe coagulation disorders
• Severe pulmonary edema or respiratory insufficiency

Storage of LIPOFUNDIN MCT/LCT 10%

• Store at controlled room temperature between 15°C and 25°C
• Protect from light and avoid freezing
• Use immediately after opening the bottle to avoid contamination
• Do not use if the emulsion appears separated, discolored, or contains visible particles
• Keep out of reach of children