LIPOCOMB 20mg/10mg Capsules (Hard Gelatin)

What is LIPOCOMB 20mg/10mg

LIPOCOMB 20mg/10mg is a fixed-dose lipid-lowering combination therapy containing two agents: Rosuvastatin zinc, a high-potency statin, and Ezetimibe, a cholesterol absorption inhibitor. This combination is prescribed to manage primary hypercholesterolemia and mixed dyslipidemia in patients requiring more aggressive LDL-C reduction. Rosuvastatin acts by inhibiting hepatic cholesterol synthesis, while ezetimibe reduces cholesterol absorption in the intestine. LIPOCOMB offers dual lipid control in a single capsule, improving patient compliance and cardiovascular risk reduction.

• Drug Class: HMG-CoA reductase inhibitor + cholesterol absorption inhibitor
• Indication: Hypercholesterolemia, high cardiovascular risk profiles
• Combined Mechanism: Targets both dietary and hepatic cholesterol sources
• Used In: Adults who are not adequately controlled by statin monotherapy

How to use LIPOCOMB 20mg/10mg

This medication should be taken exactly as prescribed by a healthcare provider. It is typically taken once daily.

• Take one capsule daily, with or without food
• Swallow the capsule whole with water; do not crush or chew
• Take at the same time each day for optimal effectiveness
• Continue a cholesterol-lowering diet during treatment
• Regular monitoring of lipid levels and liver function is recommended

Mode of Action LIPOCOMB 20mg/10mg

LIPOCOMB works by combining two complementary cholesterol-lowering mechanisms:

• Rosuvastatin: Inhibits HMG-CoA reductase, reducing cholesterol production in the liver and increasing LDL receptor activity to enhance LDL clearance from plasma.
• Ezetimibe: Inhibits cholesterol absorption at the small intestinal brush border by targeting the Niemann-Pick C1-Like 1 (NPC1L1) protein.
• The combination offers a more significant LDL reduction compared to either agent alone.

LIPOCOMB 20mg/10mg Interactions LIPOCOMB 20mg/10mg

Some medications may interact with LIPOCOMB and increase the risk of adverse effects:

• Cyclosporine: May significantly increase rosuvastatin plasma levels
• Gemfibrozil: Can elevate the risk of muscle damage and myopathy
• Antacids: Reduce rosuvastatin bioavailability; administer LIPOCOMB 2 hours before
• Warfarin: Potential alteration in anticoagulant effect; monitor INR
• Bile Acid Sequestrants: May interfere with ezetimibe absorption; stagger dosing times

Dosage of LIPOCOMB 20mg/10mg

• Standard adult dose: One capsule per day (20mg rosuvastatin / 10mg ezetimibe)
• Not suitable for patients with severe hepatic impairment
• Use with caution in patients with renal dysfunction
• Do not exceed recommended dosage without medical supervision

Possible side effects of LIPOCOMB 20mg/10mg

Most side effects are mild and temporary, though some may require medical attention:

• Common: Headache, fatigue, abdominal discomfort, diarrhea
• Muscle-related: Myalgia, muscle cramps, rare risk of rhabdomyolysis
• Hepatic: Elevated liver enzymes (AST/ALT); monitor liver function
• Rare: Hypersensitivity reactions, pancreatitis
• Contact your doctor immediately if experiencing unexplained muscle pain, weakness, or jaundice

LIPOCOMB 20mg/10mg Contraindications LIPOCOMB 20mg/10mg

• Hypersensitivity to rosuvastatin, ezetimibe, or capsule ingredients
• Active liver disease or unexplained persistent elevations in liver enzymes
• Pregnancy and lactation – statins are contraindicated in pregnancy
• Severe renal impairment (unless monitored closely)

Storage of LIPOCOMB 20mg/10mg

• Store at room temperature between 15°C and 30°C
• Keep capsules in the original blister packaging to protect from moisture
• Do not refrigerate or freeze
• Keep out of reach of children
• Dispose of expired or unused medication safely