ADGLIM 2 Tablets

What is ADGLIM 2

ADGLIM 2 is an oral antidiabetic medication that contains Glimepiride 2 mg as its active ingredient. It is classified under the class of drugs known as sulfonylureas, which are commonly used to manage blood glucose levels in individuals with type 2 diabetes mellitus.

• Manufactured in tablet form, each pack contains 30 tablets (in 10's blister × 3).
• ADGLIM 2 is not intended for use in type 1 diabetes or diabetic ketoacidosis.
• It helps in controlling high blood sugar levels, thus preventing complications such as nephropathy, retinopathy, neuropathy, and cardiovascular events.
• It is generally used in combination with diet and exercise and sometimes with other antidiabetic medications such as metformin or insulin.

By improving glycemic control, ADGLIM 2 helps reduce the risk of long-term complications associated with uncontrolled diabetes.

How to use ADGLIM 2

ADGLIM 2 should be taken exactly as prescribed by your physician. Adherence to dosing schedules and blood sugar monitoring is essential for safe and effective use.

• Timing: Take the tablet orally once daily, preferably with or just before the first main meal of the day (usually breakfast).
• Swallow whole: Do not crush or chew the tablet. Swallow it whole with a glass of water.
• Dosage adjustments: Your physician may adjust the dose based on your blood glucose levels, usually starting at a lower dose (1 mg) and titrating up to 2 mg or more if needed.
• Monitoring: Regular monitoring of blood glucose and HbA1c levels is recommended during treatment.
• Missed dose: If you forget to take a dose, skip it if it's almost time for your next one. Do not double the dose to make up for a missed one.

Always follow the doctor’s advice regarding diet, physical activity, and timing of medication to ensure optimal glycemic control with minimal risk of hypoglycemia.

Mode of Action ADGLIM 2

Glimepiride, the active ingredient in ADGLIM 2, is a second-generation sulfonylurea that works by stimulating the pancreas to release insulin. Its mechanisms of action include:

• Stimulation of Insulin Secretion: Glimepiride binds to sulfonylurea receptors (SUR1) on pancreatic β-cells, leading to closure of ATP-sensitive potassium (K_ATP) channels. This depolarizes the cell membrane, opens calcium channels, and promotes insulin release.
• Enhancement of Insulin Sensitivity: It increases the sensitivity of peripheral tissues (like muscle and fat) to insulin, improving glucose uptake.
• Reduction of Hepatic Glucose Production: Glimepiride slightly suppresses gluconeogenesis (glucose production) in the liver.
• Onset and duration: It has a rapid onset of action (within 2 hours) and long duration of glucose-lowering effect, allowing once-daily dosing.

Its dual mechanism makes it effective in lowering both fasting and postprandial blood glucose levels.

ADGLIM 2 Interactions ADGLIM 2

Several drug interactions can alter the effectiveness or increase the risk of side effects of ADGLIM 2. Here are common interaction categories:

• Drugs that enhance hypoglycemic effect:
  • Insulin or other oral antidiabetics (e.g., metformin, pioglitazone)
  • Beta-blockers (e.g., atenolol, propranolol)
  • ACE inhibitors (e.g., enalapril)
  • NSAIDs (e.g., ibuprofen)
  • Sulfonamides (e.g., sulfamethoxazole)
• Drugs that reduce hypoglycemic effect:
  • Thiazide diuretics
  • Glucocorticoids
  • Phenytoin
  • Oral contraceptives
  • Rifampin
• Alcohol: Can both increase or decrease the hypoglycemic effect; also increases risk of lactic acidosis.
• Beta-blockers: May mask signs of hypoglycemia like rapid heart rate and tremors.

Always inform your healthcare provider about all medicines you are taking, including over-the-counter drugs and supplements.

Dosage of ADGLIM 2

The dosage of ADGLIM 2 should be personalized based on the patient’s blood glucose levels, renal function, and overall health status.

• Initial dose: Typically 1 mg once daily, with or just before breakfast.
• Titration: Dose may be gradually increased in 1 mg increments at 1–2 week intervals based on response, up to a maximum of 8 mg per day.
• Maintenance dose: Common effective dose ranges from 1 mg to 4 mg once daily. ADGLIM 2 (2 mg) is suitable for intermediate stages.
• Renal impairment: Start at the lowest dose (1 mg). Dose adjustments are necessary based on kidney function.
• Elderly: Use with caution and start with the lowest possible dose due to increased risk of hypoglycemia.

Strict adherence to dosing instructions and regular monitoring are key to preventing complications such as hypoglycemia.

Possible side effects of ADGLIM 2

Like all medications, ADGLIM 2 may cause side effects. While most are mild and manageable, some may require medical attention.

• Common side effects:
  • Hypoglycemia (low blood sugar): sweating, tremors, confusion, palpitations
  • Nausea or vomiting
  • Headache
  • Weight gain
• Less common side effects:
  • Allergic skin reactions: rash, itching, or urticaria
  • Visual disturbances (usually temporary)
  • GI disturbances such as abdominal pain or diarrhea
• Rare but serious side effects:
  • Severe hypoglycemia requiring medical attention
  • Hepatic dysfunction or jaundice
  • Hematological disorders: thrombocytopenia, leukopenia
  • Allergic reactions: anaphylaxis or angioedema (very rare)

If you experience signs of severe allergic reaction or persistent side effects, seek medical help immediately.

ADGLIM 2 Contraindications ADGLIM 2

ADGLIM 2 is contraindicated in several conditions where its use may pose a health risk.

• Type 1 diabetes mellitus: Insulin is required in these patients.
• Diabetic ketoacidosis (DKA): Immediate insulin therapy is needed.
• Severe hepatic impairment: Increased risk of adverse effects due to impaired metabolism.
• Severe renal impairment: Accumulation of the drug can increase the risk of hypoglycemia.
• Known hypersensitivity: Allergy to glimepiride or other sulfonylureas/sulfonamides.
• Pregnancy and breastfeeding: Not recommended due to potential harm to the fetus or neonate; insulin is preferred.

Always disclose your full medical history to your healthcare provider before starting this medication.

Storage of ADGLIM 2

Proper storage of ADGLIM 2 helps maintain its potency and ensures safety:

• Temperature: Store at a controlled room temperature between 15°C and 30°C (59°F to 86°F).
• Humidity: Keep away from excessive moisture. Avoid storing in bathrooms.
• Packaging: Keep the tablets in their original blister packaging to protect from light and air.
• Out of reach: Store in a secure location, out of reach of children and pets.
• Do not use: Avoid using after the expiration date printed on the package.

Proper storage ensures the medication remains safe and effective throughout its shelf life.