LIORESAL 10mg Tablets

What is LIORESAL 10mg

LIORESAL 10 mg contains Baclofen as its active ingredient, a muscle relaxant primarily used to treat muscle spasticity. It acts on the central nervous system to relieve muscle stiffness, spasms, and pain caused by conditions such as multiple sclerosis, spinal cord injuries, and other neurological disorders.

• Therapeutic class: Muscle relaxant, antispastic agent
• Indications: Management of spasticity from multiple sclerosis, spinal cord lesions, cerebral palsy
• Action: Baclofen reduces nerve transmission in the spinal cord, thereby decreasing muscle spasticity and improving mobility
• Usage: Prescription-only medication, used under medical supervision

How to use LIORESAL 10mg

Always follow your healthcare provider’s instructions when using LIORESAL. The dosage may vary depending on the severity of symptoms and individual response.

• Route: Oral
• Typical dose: Usually starts low (e.g., 5 mg three times daily) and gradually increased to minimize side effects
• Frequency: Usually taken 3 times per day; some patients may require additional doses
• Do not: Abruptly stop taking LIORESAL without consulting your doctor, as sudden discontinuation can cause withdrawal symptoms
• Swallow: Tablets whole with water, with or without food

Mode of Action LIORESAL 10mg

Baclofen is a gamma-aminobutyric acid (GABA) analogue that acts as a selective agonist of GABA_B receptors in the spinal cord. Activation of these receptors inhibits excitatory neurotransmitter release, resulting in decreased muscle tone and relief from spasticity.

• Target: GABA_B receptors in the spinal cord
• Effect: Reduced nerve excitability and muscle spasm
• Result: Improved muscle control and decreased stiffness

LIORESAL 10mg Interactions LIORESAL 10mg

LIORESAL may interact with other central nervous system (CNS) depressants and medications, potentially enhancing sedation or causing adverse effects.

• Alcohol: Increases sedation and risk of respiratory depression
• Other CNS depressants: Benzodiazepines, opioids, antihistamines can potentiate drowsiness
• Antihypertensives: Possible additive blood pressure lowering effect
• Muscle relaxants: Caution with other muscle relaxants to avoid excessive weakness

Dosage of LIORESAL 10mg

Dosage is individualized; usually starts with low doses to minimize side effects and gradually increased.

• Adults: Initial dose typically 5 mg three times daily, increased by 5 mg every 3 days
• Maintenance dose: Usually 40-80 mg per day in divided doses
• Elderly and renal impairment: Dose adjustments may be necessary
• Do not exceed: Maximum daily dose as prescribed by your healthcare provider

Possible side effects of LIORESAL 10mg

Side effects range from mild to severe and should be reported to a healthcare professional if persistent or troublesome.

• Drowsiness, dizziness, weakness
• Headache, nausea, constipation
• Fatigue, hypotension
• Rarely: confusion, hallucinations, muscle weakness, seizures

LIORESAL 10mg Contraindications LIORESAL 10mg

• Known hypersensitivity to Baclofen
• Severe renal impairment (use with caution)
• Patients with a history of epilepsy (use cautiously)
• Use caution in pregnancy and breastfeeding; only if clearly needed

Storage of LIORESAL 10mg

• Store at room temperature, between 20°C and 25°C (68°F and 77°F)
• Keep away from moisture, heat, and direct sunlight
• Keep out of reach of children
• Do not use after expiry date