LINEZAN 2mg/ml Solution for infusion

What is LINEZAN 2mg/ml

LINEZAN 2 mg/ml is a ready-to-use intravenous infusion solution that contains Linezolid, a synthetic antibiotic from the oxazolidinone class. It is designed for the treatment of serious bacterial infections, especially those caused by multi-drug resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE).

• Generic Name: Linezolid
• Formulation Strength: 2 mg per 1 ml (i.e., 600 mg per 300 ml bag)
• Route: Intravenous infusion
• Indications: Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and soft tissue infections, infections with resistant Gram-positive bacteria

The IV formulation is often used in hospitalized patients when oral administration is not possible, or when a faster, controlled systemic effect is needed.

How to use LINEZAN 2mg/ml

LINEZAN should only be administered under the supervision of healthcare professionals. It is infused intravenously over a period of approximately 30 to 120 minutes, depending on patient-specific factors and institutional protocol.

• Standard Adult Dose: One 300 ml bag (600 mg) every 12 hours
• Infusion Time: 30–120 minutes
• Administration Route: IV only; do not administer via IM or bolus
• Mixing: Do not dilute or mix with other medications unless confirmed compatible
• Monitoring: Vital signs, CBC, renal and liver function if used beyond 14 days

Do not use if the solution is cloudy or contains particulate matter. Discard any unused portion.

Mode of Action LINEZAN 2mg/ml

Linezolid acts by inhibiting bacterial protein synthesis at an early stage, making it effective against resistant strains where other antibiotics fail.

• Target: 23S ribosomal RNA of the 50S subunit
• Action: Blocks initiation complex formation necessary for translation
• Effect: Bacteriostatic against most organisms, bactericidal against specific strains like streptococci

This novel mechanism reduces the risk of cross-resistance with other commonly used antibiotic classes.

LINEZAN 2mg/ml Interactions LINEZAN 2mg/ml

Linezolid is a weak, reversible monoamine oxidase inhibitor (MAOI), which means it can interact with various medications and dietary components.

• SSRIs/SNRIs: Risk of serotonin syndrome
• Adrenergic agents (e.g., pseudoephedrine): Risk of hypertensive crisis
• MAOIs: Avoid concurrent use
• Tyramine-rich foods: Aged cheese, cured meats, fermented soy—risk of hypertensive reactions
• Hypoglycemics: May increase insulin or oral antidiabetic drug effects

Always inform your provider about all medications and supplements you are taking to avoid serious interactions.

Dosage of LINEZAN 2mg/ml

The standard adult dose is one 300 ml infusion (600 mg) administered every 12 hours. The treatment duration varies based on the infection type and severity.

• Adults: 600 mg IV every 12 hours (1 bag)
• Pediatrics: Dosage is weight-based (10 mg/kg every 8–12 hours)
• Renal Impairment: No initial dose adjustment needed, but caution with prolonged use
• Hepatic Impairment: Generally safe; monitor with prolonged therapy
• Treatment Duration: Usually 10–14 days; up to 28 days in complex cases

Do not exceed the prescribed treatment duration without medical supervision due to risk of serious adverse effects.

Possible side effects of LINEZAN 2mg/ml

Linezolid is generally well-tolerated, but like all potent antibiotics, it carries a risk of both common and serious side effects.

• Common: Nausea, diarrhea, headache, taste alterations
• Moderate: Rash, insomnia, dizziness
• Serious: Bone marrow suppression (especially with treatment >14 days), optic/peripheral neuropathy, serotonin syndrome, lactic acidosis

Routine blood counts are recommended if therapy exceeds 10–14 days. Report any visual changes, unexplained fatigue, or bleeding to your provider.

LINEZAN 2mg/ml Contraindications LINEZAN 2mg/ml

• Hypersensitivity to Linezolid
• Concurrent or recent use of MAOIs
• Uncontrolled hypertension
• Hyperthyroidism or carcinoid tumors (due to risk of serotonin syndrome)
• Patients taking serotonergic or adrenergic drugs without dose modification

Evaluate risks vs. benefits carefully in patients with a history of seizure or psychiatric disorders.

Storage of LINEZAN 2mg/ml

• Store at 20–25°C (68–77°F); excursions permitted between 15–30°C
• Do not freeze or expose to extreme heat
• Protect from light; keep in original overwrap until use
• Use immediately once opened; discard partially used bags

Keep out of reach of children and dispose of according to hospital or pharmaceutical waste protocols.