LINDEC 600 mg Tablet/ Film coated

What is LINDEC 600 mg

LINDEC 600 mg is a film-coated tablet that contains the active pharmaceutical ingredient Linezolid. Linezolid is a synthetic antibiotic belonging to the oxazolidinone class. It is used to treat a wide range of bacterial infections, especially those caused by multi-drug resistant Gram-positive bacteria. This includes methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), and certain strains of Streptococcus pneumoniae.

• Generic Name: Linezolid
• Drug Class: Oxazolidinone antibiotic
• Strength: 600 mg per tablet
• Common Uses: Pneumonia (including hospital-acquired), skin and soft tissue infections, bacteremia, complicated infections with resistant bacteria

Linezolid works by inhibiting bacterial protein synthesis. Unlike most antibiotics, it binds to the 23S ribosomal RNA of the 50S subunit, preventing the formation of the initiation complex required for bacterial translation. This unique mechanism makes it effective even against bacteria resistant to other antibiotic classes.

How to use LINDEC 600 mg

LINDEC tablets should be taken orally with or without food. It is important to follow your healthcare provider’s instructions strictly and to complete the entire prescribed course, even if symptoms improve early.

• Adult Dosage: 600 mg every 12 hours (twice daily)
• Administration: Swallow whole with a full glass of water
• Duration: Usually 10 to 14 days; may be extended in complicated infections
• Do Not: Crush or split the tablet unless advised by your doctor
• Missed Dose: Take it as soon as remembered, but skip if it's close to the next dose

Consult your doctor immediately if symptoms worsen or do not improve within a few days of starting treatment.

Mode of Action LINDEC 600 mg

Linezolid, the active ingredient in LINDEC, exhibits a bacteriostatic action against most organisms, though it is bactericidal against certain strains like streptococci. Its novel mechanism disrupts bacterial protein synthesis:

• Binding Site: 23S rRNA of the 50S ribosomal subunit
• Effect: Inhibits formation of the initiation complex in protein synthesis
• Outcome: Halts bacterial growth and prevents replication

Because it acts at an earlier stage of translation than most antibiotics, Linezolid maintains efficacy even in resistant organisms, making it highly valuable for combating serious hospital-acquired infections.

LINDEC 600 mg Interactions LINDEC 600 mg

Linezolid can interact with several other medications and substances. Notably, it is a reversible, non-selective monoamine oxidase inhibitor (MAOI), which can affect neurotransmitter metabolism.

• SSRIs / SNRIs: May increase risk of serotonin syndrome
• Adrenergic Agents (e.g., pseudoephedrine): May cause hypertensive reactions
• MAOIs: Co-administration is contraindicated
• Tyramine-rich Foods: Aged cheeses, smoked meats, and fermented products should be avoided
• Insulin or Hypoglycemics: May increase risk of hypoglycemia; monitor blood sugar closely

Always inform your healthcare provider about all medications and supplements you are taking.

Dosage of LINDEC 600 mg

The standard dosage of LINDEC is 600 mg every 12 hours for adults. Dosage adjustments are not typically needed in patients with mild to moderate renal or hepatic impairment.

• Adults: 600 mg every 12 hours
• Children (if used): Dose is weight-based and under specialist care
• Renal Impairment: No initial adjustment; monitor if treatment is prolonged
• Hepatic Impairment: Usually no dose adjustment required

Do not exceed the recommended dose unless specifically advised by a physician.

Possible side effects of LINDEC 600 mg

Although effective, Linezolid can cause several side effects, particularly with prolonged use (>14 days).

• Common: Diarrhea, headache, nausea, vomiting, taste disturbances
• Less Common: Insomnia, dizziness, rash
• Serious: Myelosuppression (anemia, thrombocytopenia), optic and peripheral neuropathy (with extended use), lactic acidosis, serotonin syndrome

Routine blood monitoring is recommended for patients on prolonged therapy, especially those with pre-existing hematological conditions.

LINDEC 600 mg Contraindications LINDEC 600 mg

• Hypersensitivity to Linezolid or any excipients
• Concurrent use with monoamine oxidase inhibitors (within 2 weeks)
• Uncontrolled hypertension
• Carcinoid syndrome or pheochromocytoma

Use caution in patients with a history of seizures or those taking serotonergic or adrenergic drugs.

Storage of LINDEC 600 mg

• Store below 25°C (77°F)
• Protect from moisture and light
• Keep in original HDPE bottle with tightly closed cap
• Keep out of reach of children

Discard after the expiry date mentioned on the bottle. Do not use tablets that appear damaged or discolored.