What is ADENURIC 120mg
ADENURIC 120mg is a prescription medication containing the active ingredient Febuxostat. It belongs to a class of drugs known as xanthine oxidase inhibitors. ADENURIC is primarily used to treat chronic gout and hyperuricemia (high levels of uric acid in the blood), especially in patients who are intolerant to or have not responded well to other uric acid-lowering therapies like allopurinol.
- Indication: It is indicated for reducing serum uric acid levels to prevent gout attacks and related complications.
- Formulation: The medicine is available as film-coated tablets, each containing 120 mg of febuxostat, designed for oral administration.
- Packaging: ADENURIC 120mg typically comes in packs of 28 tablets, often arranged as 14 tablets per blister, with 2 blisters per pack.
- Purpose: By lowering uric acid levels, ADENURIC helps prevent gout flares, formation of uric acid crystals in joints, and long-term joint damage.
- Usage: It is prescribed for adults with gout and should be used under medical supervision due to the need for dose adjustment and monitoring.
How to use ADENURIC 120mg
Proper use of ADENURIC 120mg is crucial to maximize its benefits and minimize side effects. Follow these guidelines carefully:
- Consult your doctor: Before starting, inform your healthcare provider about your full medical history, allergies, and any other medications you are taking.
- Dosage: The usual starting dose is 40 mg or 80 mg once daily. Your doctor may adjust the dose to 120 mg once daily depending on your uric acid levels and response.
- Administration: Take the tablet orally, once daily, with or without food. Try to take it at the same time every day to maintain even drug levels in your bloodstream.
- Hydration: Drink plenty of water to help flush uric acid and prevent kidney stones.
- Avoid abrupt discontinuation: Do not stop taking ADENURIC without consulting your doctor, even if your symptoms improve.
- Monitoring: Regular blood tests are recommended to check uric acid levels and liver function during treatment.
- Managing gout attacks: Starting febuxostat may temporarily increase gout attacks; your doctor may prescribe anti-inflammatory medication to prevent or treat these flare-ups.
Mode of Action ADENURIC 120mg
ADENURIC 120mg works by targeting the underlying cause of gout and hyperuricemia—excess uric acid production. Its mechanism of action involves:
- Xanthine oxidase inhibition: Febuxostat selectively inhibits xanthine oxidase, an enzyme responsible for converting hypoxanthine and xanthine into uric acid.
- Reduction of uric acid: By blocking this enzyme, febuxostat reduces the synthesis of uric acid, lowering its concentration in the blood.
- Prevention of crystal formation: Lower uric acid levels help prevent the deposition of monosodium urate crystals in joints and tissues, which cause painful gout attacks.
- Selective action: Unlike some other drugs, febuxostat does not inhibit other enzymes involved in purine metabolism, making it more selective and potentially better tolerated.
- Long-lasting effect: The medication’s action maintains a steady reduction in serum uric acid, contributing to fewer flare-ups and slower disease progression.
ADENURIC 120mg Interactions ADENURIC 120mg
ADENURIC (Febuxostat) can interact with several medications, which may affect its efficacy or increase the risk of adverse effects. Important drug interactions include:
- Theophylline: Febuxostat may increase the blood levels of theophylline, raising the risk of toxicity.
- Azathioprine and Mercaptopurine: Febuxostat inhibits xanthine oxidase, which metabolizes these drugs. Concomitant use can cause dangerous increases in azathioprine or mercaptopurine levels, risking severe bone marrow suppression.
- Warfarin: Febuxostat may alter INR values; close monitoring of anticoagulation is needed when used together.
- Non-steroidal anti-inflammatory drugs (NSAIDs): These are often prescribed during the initial treatment phase to manage gout flares, but caution is required as both drugs can affect kidney function.
- Other uric acid-lowering agents: Combining febuxostat with drugs like probenecid should be done under medical supervision to avoid excessive lowering of uric acid.
- Consultation advised: Always inform your healthcare provider about all medications, including over-the-counter drugs and supplements, to avoid harmful interactions.
Dosage of ADENURIC 120mg
The dosing regimen of ADENURIC 120mg must be tailored to the patient's clinical condition and serum uric acid levels. General dosage guidelines are:
- Starting dose: Typically, treatment begins at 40 mg once daily.
- Titration: After 2 weeks, your doctor may increase the dose to 80 mg once daily if uric acid levels are not sufficiently lowered.
- Maximum dose: If necessary, the dose can be increased to 120 mg once daily, as in ADENURIC 120mg tablets.
- Maintenance: The dose should maintain serum uric acid below 6 mg/dL to prevent gout attacks.
- Renal impairment: Febuxostat can be used without dose adjustment in mild to moderate kidney impairment, but monitoring is essential.
- Hepatic impairment: Use with caution in liver disease; dosage adjustment may be required.
- Duration: Treatment is usually long-term to prevent recurrence of hyperuricemia and gout flares.
Possible side effects of ADENURIC 120mg
Like all medications, ADENURIC 120mg may cause side effects. Some are common and mild, while others may be serious and require immediate medical attention:
- Common side effects:
- Headache
- Nausea and stomach upset
- Joint pain (arthralgia)
- Rash or skin reactions
- Serious side effects:
- Severe allergic reactions including Stevens-Johnson syndrome (rare)
- Liver enzyme abnormalities—monitor liver function regularly
- Cardiovascular events: Some studies suggest a slight increase in heart-related risks; discuss with your doctor if you have heart disease.
- Kidney stones due to uric acid crystallization
- Gout flare-ups: Febuxostat may initially cause more frequent gout attacks; prophylactic treatment with NSAIDs or colchicine is often recommended during the first months.
- When to seek help: If you experience rash, difficulty breathing, swelling, jaundice, or chest pain, contact your healthcare provider immediately.
ADENURIC 120mg Contraindications ADENURIC 120mg
ADENURIC 120mg should not be used in certain situations due to safety concerns. Contraindications include:
- Hypersensitivity: Known allergy to febuxostat or any excipients in the tablet.
- Use with azathioprine or mercaptopurine: These combinations are contraindicated due to risk of severe toxicity.
- Severe liver impairment: Patients with significant hepatic dysfunction should avoid febuxostat due to risk of liver toxicity.
- Pregnancy and breastfeeding: Safety during pregnancy or lactation has not been established; avoid use unless clearly necessary.
- Active gout flare: ADENURIC should not be started during an acute gout attack; treatment should begin after flare resolution.
Storage of ADENURIC 120mg
Proper storage of ADENURIC 120mg tablets ensures their potency and safety. Follow these guidelines:
- Temperature: Store at room temperature, ideally between 20°C to 25°C (68°F to 77°F).
- Humidity: Keep the tablets in a dry place, away from moisture and humidity, which can degrade the film coating.
- Light protection: Store in the original blister pack to protect from light exposure.
- Keep out of reach of children: To prevent accidental ingestion, always store the medication securely.
- Expiry date: Do not use beyond the expiration date printed on the packaging.
- Disposal: Dispose of unused or expired tablets responsibly, following local regulations or pharmacy take-back programs.
ADENURIC 120mg features an exceptional active ingredient renowned for its potent effects, comprising Febuxostat. This powerful formulation provides a superior solution for addressing diverse health concerns. With 120mg/Tablet concentration and an easily manageable Tablets/Film-coated, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADENURIC 120mg .
Welcome to Dwaey, specifically on ADENURIC 120mg page.
This medicine contains an important and useful components, as it consists of Febuxostat.
ADENURIC 120mg is available in the market in concentration 120mg/Tablet and in the form of Tablets/Film-coated.
ALGORITHM S.A.L. is the producer of ADENURIC 120mg and it is imported from LEBANON,
The most popular alternatives of ADENURIC 120mg are listed downward .
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Frequently Asked Questions
ADENURIC 120mg should be stored according to the instructions provided by ALGORITHM S.A.L..
In general, it is recommended to store ADENURIC 120mg in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADENURIC 120mg may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADENURIC 120mg for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADENURIC 120mg. Some medications, including
ADENURIC 120mg, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADENURIC 120mg, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADENURIC 120mg without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADENURIC 120mg if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADENURIC 120mg during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 120mg/Tablet,
and the specific recommendations of ALGORITHM S.A.L..
The effects of ADENURIC 120mg on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 120mg/Tablet, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADENURIC 120mg with or without food may vary depending on the medication
and the recommendations of ALGORITHM S.A.L.. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADENURIC 120mg in children or elderly individuals may depend on various factors, including
the specific medication, type Tablets/Film-coated, and the recommendations of ALGORITHM S.A.L.. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADENURIC 120mg in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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