LIDOCAINE HYDROCHLORIDE S.A.L.F. Injection/Solution for

What is LIDOCAINE HYDROCHLORIDE S.A.L.F.

LIDOCAINE HYDROCHLORIDE S.A.L.F. is an injectable solution containing Lidocaine Hydrochloride, a local anesthetic agent. It is provided in a 50 mL glass vial, offering a concentrated solution for use in medical procedures that require local anesthesia.

• Concentration: 1% Lidocaine (10 mg/mL)
• Total Lidocaine Content: 500 mg per 50 mL vial
• Common Uses: Regional anesthesia, nerve block, epidural, and other surgical or dental procedures where localized numbing is necessary.
• Pharmacological Class: Local anesthetic (amide-type) and antiarrhythmic agent.

This formulation is designed for use by healthcare professionals and is indicated to provide temporary relief from pain during medical procedures. It is effective in a wide range of applications due to its rapid onset and efficient numbing effects.

How to use LIDOCAINE HYDROCHLORIDE S.A.L.F.

LIDOCAINE HYDROCHLORIDE S.A.L.F. should only be administered by qualified healthcare providers. The dosage and method of administration will depend on the type of procedure being performed, as well as patient-specific factors.

• Infiltration Anesthesia: The solution is injected directly into the tissue to provide localized numbness. Common dosages range from 5 to 20 mL, depending on the size of the area to be anesthetized.
• Peripheral Nerve Block: This method involves injecting the solution around a nerve to block sensation. Typically, 5–10 mL is used per site.
• Maximum Dose: The maximum allowable dose for adults is generally 4.5 mg/kg of body weight, not exceeding 300 mg in a single administration.
• Multi-Dose Use: Since the vial contains 50 mL, it is important to follow appropriate protocols for multi-dose use to ensure sterility and minimize risks.

Always ensure that the solution is injected slowly and in accordance with established medical protocols to avoid complications such as toxicity or overdosing.

Mode of Action LIDOCAINE HYDROCHLORIDE S.A.L.F.

Lidocaine works by blocking sodium channels in nerve cells, which prevents the generation and conduction of electrical impulses. By doing so, it interrupts the pain signals sent to the brain from the targeted area, thereby producing localized anesthesia.

• Action on Nerves: Lidocaine inhibits the influx of sodium ions, which are necessary for the transmission of pain signals along nerve fibers.
• Onset and Duration: The anesthetic effect usually begins within 2–5 minutes of injection, with a duration of 30–60 minutes, depending on the dose and procedure.
• Antiarrhythmic Effect: Lidocaine can also stabilize the heart's electrical activity, making it useful in the treatment of certain arrhythmias.

This dual action of Lidocaine—acting as both a local anesthetic and an antiarrhythmic—makes it an essential agent in clinical medicine.

LIDOCAINE HYDROCHLORIDE S.A.L.F. Interactions LIDOCAINE HYDROCHLORIDE S.A.L.F.

Lidocaine may interact with other medications, potentially altering its effectiveness or increasing the risk of side effects. It is crucial to inform your healthcare provider about any other medications you are taking, including over-the-counter products and supplements.

• CYP3A4 Inhibitors: Medications like ketoconazole, erythromycin, or grapefruit juice can inhibit the metabolism of Lidocaine, increasing blood levels and potential toxicity.
• Beta-Blockers: These drugs, such as propranolol, may enhance the effects of Lidocaine, leading to an increased risk of side effects like bradycardia (slow heart rate).
• Amiodarone: This antiarrhythmic medication can raise Lidocaine levels, increasing the risk of toxicity and other adverse effects.
• Other Local Anesthetics: When used together with other local anesthetics, Lidocaine can increase the risk of systemic toxicity. Avoid concurrent use unless directed by a healthcare professional.

Consult your doctor before using Lidocaine with any other medications to avoid harmful interactions.

Dosage of LIDOCAINE HYDROCHLORIDE S.A.L.F.

The correct dosage of Lidocaine Hydrochloride S.A.L.F. depends on the medical procedure being performed and the patient's specific needs.

• Infiltration Anesthesia: Typically, 5–10 mL of the solution (50–100 mg) per site is used.
• Nerve Block: 3–5 mL (30–50 mg) is usually sufficient for a localized nerve block.
• Maximum Recommended Dose: The maximum dose is 4.5 mg/kg body weight, up to a total of 300 mg for an adult.
• Multi-Dose Vial: Use only the required amount from the 50 mL vial per procedure, ensuring that the vial is properly sealed and not contaminated.

The healthcare provider will determine the appropriate dose based on patient factors and the specific procedure being performed.

Possible side effects of LIDOCAINE HYDROCHLORIDE S.A.L.F.

While Lidocaine is generally safe when administered appropriately, there are potential side effects that can occur, especially if the dosage is too high or the solution is injected improperly.

• CNS Effects: Drowsiness, dizziness, headache, or in severe cases, seizures.
• Cardiovascular Effects: Hypotension (low blood pressure), bradycardia (slow heart rate), and arrhythmias.
• Injection Site Reactions: Pain, redness, or swelling at the site of injection.
• Allergic Reactions: Rash, itching, or swelling at the injection site or more severe reactions such as anaphylaxis.

If any of these side effects are experienced, or if symptoms worsen, seek immediate medical attention.

LIDOCAINE HYDROCHLORIDE S.A.L.F. Contraindications LIDOCAINE HYDROCHLORIDE S.A.L.F.

Lidocaine Hydrochloride should not be used in certain situations due to the potential for serious complications.

• Hypersensitivity: Individuals with a known allergy or hypersensitivity to Lidocaine or other amide-type anesthetics should avoid using this medication.
• Severe Heart Disease: Patients with severe bradycardia, heart block, or other serious arrhythmias should not receive Lidocaine.
• Liver Impairment: Lidocaine is metabolized by the liver, so patients with severe liver disease should be closely monitored.
• Infection or Inflammation at the Injection Site: Avoid using Lidocaine at sites with active infection or inflammation.

It is essential to consult with your healthcare provider before using this medication, particularly if you have any of the above conditions.

Storage of LIDOCAINE HYDROCHLORIDE S.A.L.F.

• Temperature: Store at room temperature (15°C to 30°C / 59°F to 86°F). Protect from freezing.
• Light Protection: Keep the vial away from direct light exposure.
• Storage Location: Store the vial in a secure location, out of reach of children and unauthorized persons.
• Use and Disposal: Discard any unused solution from the vial after a single procedure. Do not reuse or store unused portions.

Ensure that the solution is clear and free from particles before use. If the solution appears discolored or contains any particulate matter, discard the vial.