LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) Sterile solvent for Injection

What is LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) is a sterile solution intended for injection, containing 1% Lidocaine Hydrochloride (equivalent to 10 mg/mL). This product is primarily used for local anesthesia and is suitable for various medical procedures where pain relief is required. It is available in a 3.5 mL LDPE (Low-Density Polyethylene) ampoule for single-use applications.

• Concentration: 1% w/v (10 mg/mL)
• Total Lidocaine Content: 35 mg per 3.5 mL ampoule
• Common Uses: Local anesthetic for dental, minor surgical procedures, and nerve blocks.
• Pharmacological Class: Local anesthetic (amide-type) and antiarrhythmic agent.

This formulation is designed to provide effective pain relief by blocking nerve transmission at the site of injection. It is typically used in clinical settings under the supervision of a healthcare provider.

How to use LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) should only be administered by healthcare professionals. The dosage and route of administration depend on the specific procedure and the area requiring anesthesia.

• Infiltration Anesthesia: Inject the solution directly into the tissue to block pain. Typically, 5–10 mL (50–100 mg) may be used per site depending on the size of the area.
• Nerve Block: For nerve blocks, smaller amounts, typically 3–5 mL per nerve, are injected to block pain transmission.
• Maximum Dosage: The maximum recommended dose is generally 4.5 mg/kg of body weight, not exceeding 300 mg for an adult.
• Single-Use: Only use one ampoule per procedure. Discard any unused solution.

Ensure that the solution is injected slowly and in controlled amounts to minimize the risk of toxicity and complications. Always follow the healthcare provider's instructions.

Mode of Action LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Lidocaine is an amide-type local anesthetic that works by inhibiting sodium ion influx through voltage-gated sodium channels in nerve cells. This prevents the initiation and conduction of nerve impulses, effectively numbing the targeted area.

• Action on Nerves: Lidocaine blocks the nerve's ability to transmit pain signals to the brain, providing localized anesthesia.
• Antiarrhythmic Effect: Lidocaine also stabilizes the electrical activity of the heart, making it useful in treating certain arrhythmias.
• Onset and Duration: The anesthetic effect typically begins within 2–5 minutes and lasts for about 30–60 minutes depending on the dose and area of injection.

Lidocaine is one of the most commonly used anesthetics due to its rapid onset and predictable effects.

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) Interactions LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Certain drugs can interact with Lidocaine, altering its effects. It is essential to inform your healthcare provider about all medications being taken, including prescription, over-the-counter, and herbal products.

• CYP3A4 Inhibitors: Medications like ketoconazole and erythromycin can inhibit the metabolism of Lidocaine, potentially increasing its blood levels and the risk of toxicity.
• Beta-Blockers: Drugs such as propranolol can increase Lidocaine concentrations in the blood, raising the potential for side effects.
• Amiodarone: This antiarrhythmic agent may increase Lidocaine levels, requiring closer monitoring for signs of toxicity.
• Phenytoin: Phenytoin may reduce Lidocaine's effectiveness when used together, affecting its antiarrhythmic properties.
• Other Local Anesthetics: Concurrent use of multiple local anesthetics increases the risk of systemic toxicity, especially affecting the central nervous system and cardiovascular system.

Always consult your healthcare provider regarding any potential drug interactions before using Lidocaine.

Dosage of LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

The appropriate dosage of Lidocaine is determined based on the type of procedure, patient factors, and the area to be anesthetized.

• Infiltration Anesthesia: Typical doses range from 5–10 mL (50–100 mg) per site depending on the size of the area being treated.
• Nerve Block: A smaller dose of 3–5 mL is typically used per nerve to effectively block pain transmission.
• Maximum Recommended Dose: For an adult, the maximum safe dose is usually 4.5 mg/kg body weight, which equals approximately 300 mg in total.
• Single Use: Use only the prescribed amount from the 3.5 mL ampoule per procedure, and discard any remaining solution.

Your healthcare provider will determine the precise amount based on your individual needs and the procedure being performed.

Possible side effects of LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Though Lidocaine is generally well-tolerated, side effects may occur, particularly if used in excess or in individuals with certain health conditions.

• CNS Effects: Dizziness, drowsiness, blurred vision, or, in severe cases, seizures or loss of consciousness.
• Cardiovascular Effects: Low blood pressure, bradycardia (slow heart rate), and arrhythmias, particularly with excessive doses.
• Injection Site Reactions: Pain, redness, or swelling at the injection site.
• Allergic Reactions: Rash, itching, or rare anaphylaxis in sensitive individuals.

If any serious reactions occur, such as difficulty breathing or chest pain, immediate medical attention should be sought.

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) Contraindications LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Lidocaine should not be used in patients with certain medical conditions due to the potential for adverse effects.

• Hypersensitivity: Known allergy or hypersensitivity to Lidocaine or other amide-type anesthetics.
• Severe Heart Conditions: Uncontrolled bradycardia, heart block, or arrhythmias (without a pacemaker).
• Liver Disease: Lidocaine is metabolized in the liver, so patients with severe liver dysfunction should use it with caution.
• Infected or Inflammated Sites: Avoid injection in areas with active infections or inflammation.

Consult your healthcare provider if you have any of the above conditions before using Lidocaine.

Storage of LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

• Temperature: Store the ampoules at room temperature (15°C to 30°C / 59°F to 86°F). Do not freeze.
• Light Protection: Keep the ampoule protected from direct light.
• Storage Location: Keep out of the reach of children and unauthorized individuals.
• Single-Use: After opening the ampoule, discard any unused solution to prevent contamination.

Ensure the solution remains clear and free from particles. If the solution appears discolored, discard it.