LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) Sterile solvent for Injection

What is LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) is a sterile injectable solution containing Lidocaine Hydrochloride at a 1% concentration (equivalent to 10 mg/mL). This formulation is typically used as a local anesthetic or for nerve block during medical procedures. It is available in 2 mL LDPE (Low-Density Polyethylene) ampoules, designed for single-use, and is meant for injection into tissues to prevent or alleviate pain.

• Concentration: 1% w/v (10 mg/mL)
• Total Lidocaine Content: 20 mg per 2 mL ampoule
• Common Uses: Local anesthesia in dental procedures, minor surgeries, and nerve blocks.
• Pharmacological Class: Local anesthetic (amide-type) and antiarrhythmic agent.

This solution is intended for short-term use in a sterile environment under the supervision of a healthcare provider. It offers effective pain relief by blocking nerve signals, making it ideal for various minor procedures.

How to use LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) is used for local anesthesia by injection. Proper technique and careful dosing are essential for safe administration.

• Infiltration Anesthesia: The solution can be injected directly into the tissue at the site where anesthesia is needed. Typical doses range from 5–10 mL (50–100 mg) depending on the size of the area and the procedure.
• Nerve Block: For nerve blocks, a smaller volume, usually 3–5 mL per nerve, is administered to block pain transmission.
• Maximum Dose: The recommended maximum dose is typically 4.5 mg/kg body weight, not exceeding 300 mg for adults.
• Single-Use: Discard any unused solution after administration to avoid contamination.

Always use LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) under medical supervision. Do not exceed the recommended dosage and avoid injecting into highly vascular areas.

Mode of Action LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Lidocaine is a local anesthetic that works by inhibiting sodium ion influx into nerve cells. This blocks the action potential required for nerve conduction, effectively preventing pain signals from reaching the brain.

• Local Anesthesia: Lidocaine temporarily numbs the area by disrupting nerve impulse transmission, allowing for painless procedures.
• Antiarrhythmic Action: Lidocaine also has an antiarrhythmic effect, stabilizing the electrical activity in the heart by blocking sodium channels, which helps manage certain types of arrhythmias.
• Onset and Duration: The anesthetic effect typically begins within 2–5 minutes of administration and can last for 30 minutes to 1 hour, depending on the dose and procedure.

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) Interactions LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Lidocaine can interact with other medications, altering its effects or causing adverse reactions. Be sure to inform your healthcare provider of all medications being used to avoid harmful interactions.

• Beta-Blockers: Medications like propranolol may increase Lidocaine plasma concentrations, leading to toxicity.
• CYP3A4 Inhibitors: Drugs such as ketoconazole or erythromycin can inhibit the metabolism of Lidocaine, increasing its levels and potential for side effects.
• Amiodarone: This antiarrhythmic drug can increase Lidocaine levels in the body, leading to the risk of toxicity, particularly in patients with arrhythmias.
• Phenytoin: Phenytoin may reduce the effectiveness of Lidocaine when both are used together.
• Other Local Anesthetics: Using multiple local anesthetics in combination can increase the risk of toxicity, especially affecting the heart and central nervous system.

Always consult your healthcare provider regarding potential drug interactions before using Lidocaine.

Dosage of LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Lidocaine dosage should be tailored to the individual patient based on the procedure being performed. The general dosage guidelines for LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) are as follows:

• Infiltration Anesthesia: 5–10 mL (50–100 mg) per site, depending on the procedure and area of treatment.
• Nerve Block: Generally, 3–5 mL per nerve is used for effective nerve block.
• Maximum Safe Dose: The total dose should not exceed 4.5 mg/kg body weight, which for an average adult is approximately 300 mg.
• Single Dose: Use only one ampoule (2 mL) per injection site as recommended, discarding any leftover solution.

Always monitor the patient for adverse effects and adjust the dose accordingly, especially in patients with liver or kidney problems.

Possible side effects of LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

While Lidocaine is generally safe when used correctly, side effects may occur, particularly with overdose or misuse.

• CNS Effects: Symptoms like dizziness, confusion, drowsiness, or, in severe cases, seizures and loss of consciousness.
• Cardiovascular Reactions: Possible bradycardia (slow heart rate), hypotension (low blood pressure), and arrhythmias, particularly with high doses.
• Injection Site Reactions: Pain, redness, or swelling at the injection site.
• Allergic Reactions: Rare but may include rash, itching, or anaphylaxis in extreme cases.

In case of severe reactions, seek immediate medical attention.

LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject) Contraindications LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

Lidocaine should not be used in certain circumstances due to the potential for adverse effects:

• Allergic Reactions: Known hypersensitivity or allergy to Lidocaine or other amide-type anesthetics.
• Severe Cardiac Conditions: Patients with severe heart block (without a pacemaker), bradycardia, or untreated arrhythmias.
• Acute Liver Disease: Lidocaine metabolism is impaired in liver disease, increasing the risk of toxicity.
• Infected or Inflamed Sites: Do not inject Lidocaine into areas with active infections or inflammation.

Consult your healthcare provider if you have any of these conditions before using Lidocaine.

Storage of LIDOCAINE HYDROCHLORIDE 1% w/v (Gulf Inject)

• Temperature: Store at room temperature (15°C to 30°C / 59°F to 86°F). Do not freeze or refrigerate.
• Light Protection: Keep the ampoule away from direct light to preserve the medication's effectiveness.
• Out of Reach of Children: Store the product out of reach of children and unauthorized individuals.
• Single-Use: Discard any unused solution after a single administration to prevent contamination.

Ensure the solution remains clear and free from visible particles. If the solution appears discolored, discard it.